Activin A Receptor Type II-Like 1 Proteins (ACVRL1)

ACVRL1 encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. Additionally we are shipping ACVRL1 Antibodies (157) and ACVRL1 Kits (25) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ACVRL1 94 P37023
ACVRL1 25237 P80203
ACVRL1 11482 Q61288
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Top ACVRL1 Proteins at antibodies-online.com

Showing 10 out of 21 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human Fc Tag 100 μg Log in to see 20 to 21 Days
$250.80
Details
HOST_Human Cells Mouse Fc Tag,His tag 100 μg Log in to see 20 to 21 Days
$250.80
Details
HOST_Human Cells Dog Fc Tag 100 μg Log in to see 20 to 21 Days
$250.80
Details
HOST_Human Cells Rat Fc Tag,His tag 100 μg Log in to see 20 to 21 Days
$250.80
Details
HOST_HEK-293 Cells Human His tag Human ALK-1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 97%. 100 μg Log in to see 2 to 3 Days
$286.00
Details
HOST_Human Cells Cynomolgus Fc Tag 100 μg Log in to see 20 to 21 Days
$250.80
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$4,244.78
Details
HOST_Mammalian Cells Mouse Fc Tag   50 μg Log in to see 4 Days
$144.38
Details
HOST_Human Cells Cynomolgus His tag,ECD SDS-PAGE 100 μg Log in to see 20 to 21 Days
$272.80
Details

ACVRL1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
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Rat (Rattus) ,
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Mouse (Murine) , ,
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Top referenced ACVRL1 Proteins

  1. Human ACVRL1 Protein expressed in Human Cells - ABIN2002005 : ten Dijke, Ichijo, Franzén, Schulz, Saras, Toyoshima, Heldin, Miyazono: Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity. in Oncogene 1993 (PubMed)
    Show all 6 references for 2002005

  2. Rat (Rattus) ACVRL1 Protein expressed in Human Cells - ABIN2003112 : Wu, Chen, Huang, Xie, Guo: [Percutaneous hollow screws for treatment of the vertical sacrum longitudinal fracture]. in Zhongguo gu shang = China journal of orthopaedics and traumatology 2009 (PubMed)
    Show all 6 references for 2003112

  3. Dog (Canine) ACVRL1 Protein expressed in Human Cells - ABIN2008895 : Chen, Massagué: Smad1 recognition and activation by the ALK1 group of transforming growth factor-beta family receptors. in The Journal of biological chemistry 1999 (PubMed)
    Show all 6 references for 2008895

  4. Mouse (Murine) ACVRL1 Protein expressed in Human Cells - ABIN2007514 : Panchenko, Williams, Brody, Yu: Type I receptor serine-threonine kinase preferentially expressed in pulmonary blood vessels. in The American journal of physiology 1996 (PubMed)
    Show all 6 references for 2007514

  5. Cynomolgus ACVRL1 Protein expressed in Human Cells - ABIN2009783 : Johnson, Berg, Baldwin, Gallione, Marondel, Yoon, Stenzel, Speer, Pericak-Vance, Diamond, Guttmacher, Jackson, Attisano, Kucherlapati, Porteous, Marchuk: Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2. in Nature genetics 1996 (PubMed)
    Show all 6 references for 2009783

  6. Human ACVRL1 Protein expressed in HEK-293 Cells - ABIN2180578 : Lawlor, Read, Edelstein, Yang, Pierson, Stein, Wermer-Colan, Buj-Bello, Lachey, Seehra, Beggs: Inhibition of activin receptor type IIB increases strength and lifespan in myotubularin-deficient mice. in The American journal of pathology 2011 (PubMed)
    Show all 2 references for 2180578

More Proteins for Activin A Receptor Type II-Like 1 (ACVRL1) Interaction Partners

Cow (Bovine) Activin A Receptor Type II-Like 1 (ACVRL1) interaction partners

  1. Results show that ALK5 (show TGFBR1 Proteins) and ALK1 play antagonistic roles in TGF-beta (show TGFB1 Proteins)-induced podosome formation in aortic endothelial cells.

  2. ALK1 and ALK5 are both essential for correct regulation of VEGF, and that disruption of either pathway leads to disease.

Zebrafish Activin A Receptor Type II-Like 1 (ACVRL1) interaction partners

  1. alk1 loss has no effect on arterial endothelial cell proliferation but alters arterial endothelial cell migration within lumenized vessels.

  2. Control of Notch (show NOTCH1 Proteins) targets in arterial endothelium is context-dependent, with gene-specific and region-specific requirements for Notch (show NOTCH1 Proteins) and Alk1

  3. Blood flow is required not only for alk1 expression but also for Alk1 activity.

  4. Study demonstrate that alk1 expression requires blood flow, and despite normal levels of shear stress, some flow-responsive genes are dysregulated in alk1 mutant arterial endothelial cells.

  5. vbg encodes activin receptor-like kinase 1 (acvrl1), a TGFbeta (show TGFB1 Proteins) type I receptor that is expressed predominantly in the endothelium of the vessels that become dilated in vbg mutants.

Human Activin A Receptor Type II-Like 1 (ACVRL1) interaction partners

  1. c.1027C > T(p.Gln343) mutation within the ACVRL1 gene in family with hereditary hemorrhagic telangiectasia

  2. Bone morphogenetic protein (BMP)9 (show GDF2 Proteins) and BMP10 (show BMP10 Proteins) are high affinity ligands for activin receptor-like kinase 1 (ALK1).

  3. Activin receptor-like kinase (ALK)1 is a transforming growth factor beta (TGF-beta) type I receptor (show TGFBR1 Proteins) predominantly expressed in actively proliferating endothelial cells (ECs).

  4. Two novel missense mutations and two recurrent mutations in the ACVRL1 gene are associated with pulmonary arterial hypertension in in Chinese families.

  5. ALK1 expression and microvessel density are increased in oral lichen planus , particularly in atrophic/erosive OLP type.

  6. The genetic-interactions among BMPR-2 (show BMPR2 Proteins), ALK-1, and 5-HTT (show SLC6A4 Proteins) polymorphisms, elevated BMP-2 (show BMP2 Proteins) and 5-HT (show DDC Proteins) levels and differential gene expression substantiated the strong genetic contribution in high altitude pulmonary edema pathophysiology.

  7. Study of four patients with pulmonary arterial hypertension associated with human immunodeficiency virus infection found predisposing mutations in the BMPR2 (show BMPR2 Proteins), ACVRL1 and ENG (show ENG Proteins) genes.

  8. The preponderance of ACVRL1 mutations was due to founder mutations, specifically, c.830C>A (p.Thr277Lys), which was found in 24 families from the same geographical area of Norway.

  9. Report interaction between ALK1 signaling and connexin40 in the development of arteriovenous malformations.

  10. Data suggest ALK1 and ACVR2A (show ACVR2A Proteins)/ACVR2B (show ACVR2B Proteins), acting as BMP9 (show GDF2 Proteins) co-receptors, rearrange pro-domains of BMP9 (show GDF2 Proteins)--pro-domain dimer complex leading to displacement of pro-domains after receptor binding, release of mature non-dimer BPM9, and activation of signaling.

Mouse (Murine) Activin A Receptor Type II-Like 1 (ACVRL1) interaction partners

  1. these studies characterize an accessory TGF-beta (show TGFB1 Proteins)-stimulated BMP R-Smad (show SMAD1 Proteins) signaling mechanism in interstitial cells of the developing lung.

  2. this study demonstrates that ACVRL1 signaling plays a pivotal role whereby it suppresses plasmacytoid dendritic cell development while enhancing that of CD8alpha(+) dendritic cells, thus contributing to DC diversity development.

  3. CD109 (show CD109 Proteins) differentially regulates TGF-beta (show TGFB1 Proteins)-induced ALK1-Smad1 (show SMAD1 Proteins)/5 versus ALK5 (show TGFBR1 Proteins)-Smad2 (show SMAD2 Proteins)/3 pathways, leading to decreased extracellular matrix production in the skin; epidermal CD109 (show CD109 Proteins) expression regulates dermal function through a paracrine mechanism

  4. he results of the present study demonstrated that BMP9 promoted the osteoclast differentiation of osteoclast precursors via binding to the ALK1 receptor on the cell surface, and inhibiting the ERK1/2 signaling pathways in the cell

  5. Conclude that the ALK-1 receptor is involved in the control of arterial pressure. High AP of Alk1(+/-) mice is explained mainly by the sympathetic overactivation, which is probably related to the decreased number of cholinergic neurons.

  6. Report interaction between ALK1 signaling and connexin40 in the development of arteriovenous malformations.

  7. In vascular sprouting, neuropilin-1 (show NRP1 Proteins) suppresses the stalk-cell phenotype by limiting Smad2 (show SMAD2 Proteins)/3 activation through Alk1 and Alk5 (show TGFBR1 Proteins). Notch (show NOTCH1 Proteins) downregulates Nrp1 (show NRP1 Proteins), thus relieving the inhibition of Alk1 and Alk5 (show TGFBR1 Proteins), thereby driving stalk-cell behaviour.

  8. BMP9 (show GDF2 Proteins)/ALK1 augmented vasculogenesis and angiogenesis, and thereby enhanced neovascularization. Thus, we suggest that BMP9 (show GDF2 Proteins)/ALK1 may improve the efficacy of EPC (show TCF21 Proteins)-based therapies for treating ischemic diseases.

  9. BMP-9 (show GDF2 Proteins) induces vascular smooth muscle cell osteogenic differentiation and calcification via ALK1, Smad (show SMAD1 Proteins) and ALP (show CCL21A Proteins) dependent mechanisms.

  10. during development, endothelial Acvrl1 plays an essential role to regulate endothelial cell proliferation and arterial identity during angiogenesis, whilst in adult life endothelial Acvrl1 is required to maintain vascular integrity.

ACVRL1 Protein Profile

Protein Summary

This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.

Gene names and symbols associated with ACVRL1

  • activin A receptor type II-like 1 (ACVRL1)
  • activin A receptor type II-like 1 (acvrl1)
  • activin A receptor type II-like 1 (Acvrl1)
  • activin A receptor, type II-like 1 (Acvrl1)
  • ACVRL1 protein
  • Acvrlk1 protein
  • AI115505 protein
  • AI427544 protein
  • ALK-1 protein
  • Alk1 protein
  • HHT protein
  • HHT2 protein
  • hm:zehn1109 protein
  • ORW2 protein
  • R-3 protein
  • R3 protein
  • SETHKIR protein
  • SKR3 protein
  • TSR-I protein
  • vgb protein
  • zehn1109 protein

Protein level used designations for ACVRL1

activin A receptor type II-like 1 , serine/threonine-protein kinase receptor R3 , serine/threonine-protein kinase receptor R3-like , activin receptor-like kinase 1 , vbg , violet beauregarde , TGF-B superfamily receptor type I , activin A receptor, type II-like kinase 1 , Activin receptor like kinase 1 , SKR3 , TSR-I , ALK-1 , activin receptor-like kinase-1

GENE ID SPECIES
451910 Pan troglodytes
534536 Bos taurus
696471 Macaca mulatta
100061313 Equus caballus
100135773 Felis catus
100482358 Ailuropoda melanoleuca
266753 Danio rerio
94 Homo sapiens
25237 Rattus norvegicus
477603 Canis lupus familiaris
100153279 Sus scrofa
100172614 Pongo abelii
11482 Mus musculus
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