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anti-Activin Receptor Type I (ACRV1) Antibodies

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Additionally we are shipping Activin Receptor Type I Proteins (29) and Activin Receptor Type I Kits (23) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ACRV1 11477 P37172
ACRV1 90 Q04771
ACRV1 79558 P80201
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Top anti-Activin Receptor Type I Antibodies at antibodies-online.com

Showing 10 out of 148 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB Host: Rabbit  Target Name: ACVR1  Sample Tissue: Human Fetal Heart  Antibody Dilution: 1.0 µg/mL Host: Rabbit  Target Name: ACVR1  Sample Tissue: Human Fetal Lung  Antibody Dilution: 1.0 µg/mL 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-ACVR1 Antibody Titration: 0.2-1 ug/mlPositive Control: HepG2 cell lysate Immunohistochemistry with Kidney tissue at an antibody concentration of 5µg/ml using anti-ACVR1 antibody (ARP45040_P050) 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of ACVR1 (arrow) using rabbit polyclonal ACVR1 Antibody (Center) (ABIN657777). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the ACVR1 gene. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of anti-ACVR1 Pab (ABIN391156) in mouse brain tissue lysate. ACVR1(arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of ACVR1 (arrow) using rabbit polyclonal ACVR1 Antibody (Center N153) (ABIN391154). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the ACVR1 gene (Lane 2) (Origene Technologies). Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma Western blot analysis of anti-ACVR1 Pab (ABIN391155) in mouse brain tissue lysate.ACVR1(arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB The anti-ACVR1 Pab (ABIN392240) is used in Western blot to detect ACVR1 in HeLa cell lysate (Lane 1) and mouse liver tissue lysate (Lane 2). Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Goat Un-conjugated IHC, ELISA, WB ABIN238620 (0.3µg/ml) staining of Human Umbilical Cord lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Rabbit Un-conjugated IHC (p), WB Mouse Acvr1 Antibody (Center) (ABIN657718) western blot analysis in mouse bladder tissue lysates (35 µg/lane). This demonstrates the Acvr1 antibody detected the Acvr1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-ACVR1 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN1099817 concentration 5 ug/ml. 50 μg Log in to see 8 to 10 Days
$676.50
Details

ACRV1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Activin Receptor Type I Antibodies

  1. Human Polyclonal ACRV1 Primary Antibody for IHC (p), WB - ABIN392240 : ten Dijke, Ichijo, Franzén, Schulz, Saras, Toyoshima, Heldin, Miyazono: Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity. in Oncogene 1993 (PubMed)
    Show all 4 references for ABIN392240

  2. Human Polyclonal ACRV1 Primary Antibody for WB - ABIN657777 : Canzian, Cox, Setiawan, Stram, Ziegler, Dossus, Beckmann, Blanché, Barricarte, Berg, Bingham, Buring, Buys, Calle, Chanock, Clavel-Chapelon, DeLancey, Diver, Dorronsoro, Haiman, Hallmans, Hankinson, Hunter, Hüsing, Isaacs, Khaw, Kolonel, Kraft, Le Marchan: Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium. in Human molecular genetics 2010 (PubMed)
    Show all 4 references for ABIN657777

  3. Human Polyclonal ACRV1 Primary Antibody for IHC, ELISA - ABIN238620 : Shore, Xu, Feldman, Fenstermacher, Cho, Choi, Connor, Delai, Glaser, LeMerrer, Morhart, Rogers, Smith, Triffitt, Urtizberea, Zasloff, Brown, Kaplan: A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva. in Nature genetics 2006 (PubMed)

  4. Human Polyclonal ACRV1 Primary Antibody for IHC (p), WB - ABIN391155 : Casagrandi, Bearfield, Geary, Redman, Muttukrishna: Inhibin, activin, follistatin, activin receptors and beta-glycan gene expression in the placental tissue of patients with pre-eclampsia. in Molecular human reproduction 2003 (PubMed)

  5. Cow (Bovine) Polyclonal ACRV1 Primary Antibody for WB - ABIN2782108 : Kariyawasam, Xanthou, Barkans, Aizen, Kay, Robinson: Basal expression of bone morphogenetic protein receptor is reduced in mild asthma. in American journal of respiratory and critical care medicine 2008 (PubMed)

  6. Human Polyclonal ACRV1 Primary Antibody for WB - ABIN391156 : Kan, Liu, McGuire, Berger, Awatramani, Dymecki, Kessler: Dysregulation of local stem/progenitor cells as a common cellular mechanism for heterotopic ossification. in Stem cells (Dayton, Ohio) 2009 (PubMed)

More Antibodies against Activin Receptor Type I Interaction Partners

Mouse (Murine) Activin Receptor Type I (ACRV1) interaction partners

  1. Suggest that BMP signaling upregulates the calcineurin (show PPP3CA Antibodies)/nuclear factor of activated T cell (show NFATC3 Antibodies) pathway via BMP type I receptor ALK2, contributing to cardiac hypertrophy and fibrosis.

  2. results suggest that ACVR1(R206H) causes FOP (show CHTOP Antibodies) by gaining responsiveness to the normally antagonistic ligand activin A (show INHBA Antibodies), demonstrating that this ligand is necessary and sufficient for driving HO in a genetically accurate model of FOP (show CHTOP Antibodies)

  3. The findings suggest that the mutant ALK2 related to Fibrodysplasia ossificans progressiva is enhanced by bone morphogenetic protein type II receptors via the T203-regulated phosphorylation of ALK2.

  4. ACVR1 is required for chondrocyte proliferation and differentiation, particularly in craniofacial and axial elements, but exerts coordinated functions with both BMPR1A (show BMPR1A Antibodies) and BMPR1B (show BMPR1B Antibodies) throughout the developing endochondral skeleton

  5. expression of constitutively active ALK2 receptor results in significantly increased ASC (show STS Antibodies) osteogenic differentiation.

  6. SP-10 is a useful marker for staging the cycle of the seminiferous epithelium. The anti-SP-10 antibody works well in different fixatives, on paraffin-embedded as well as cryosections

  7. Data indicate that activin A receptor type 1 (Alk2) is a direct regulator of cartilage formation and mediates chondrogenic commitment of progenitor cells.

  8. Tmem176b (show TMEM176B Antibodies) mRNA levels were upregulated by stable transfection of ALK2 (R206H) in mouse myoblastic C2C12 cells.

  9. AcvR1-mediated BMP signaling in second heart field is required for arterial pole development: implications for myocardial differentiation and regional identity.

  10. Our work clarifies the conserved mechanisms through which BMPs regulate peri (show POSTN Antibodies)-implantation in rodents and primates and, for the first time, uncovers a linear pathway of BMP signaling through ALK2 to regulate CEBPB (show CEBPB Antibodies)

Human Activin Receptor Type I (ACRV1) interaction partners

  1. Common mutations in ALK2/ACVR1, a multi-faceted receptor, have roles in distinct pediatric musculoskeletal and neural orphan disorders.

  2. The higher PE activin A (show INHBA Antibodies) concentrations resulted in abnormal endothelial functions, which may contribute to the systemic maternal vascular endothelial cell dysfunction observed in the disorder.

  3. A report of two patients has been presented with multi-system involvement in a severe variant of fibrodysplasia ossificans progressiva caused by the ACVR1 c.772G>A; R258G mutation.

  4. Fibrodysplasia ossificans progressiva-ACVR1 abnormally transduces bone morphogenetic protein signaling in response to Activin-A (show INHBA Antibodies).

  5. Changes in the binding site residue(e.g. pre-hinge region in ALK2) or side chain orientation (e.g. Tyr219 in caALK2 vs. wtALK2), or ligand modification (e.g. DMH1 vs. LDN193189) causes distinct binding profiles and selectivity among BMP inhibitors.

  6. heterozygous mutation i.e., c.617(G>A)in ACVR1 was detected in patients with rare genetic disorder - Fibrodysplasia ossificans progressiva

  7. miR (show MLXIP Antibodies)-148a is an important mediator of ACVR1, thus offering a new potential target for the development of therapeutic agents against Fibrodysplasia ossificans progressiva.

  8. Genetic analysis of ACVR1 identified the recurrent allelic variant c.617 G>A; p.R206H in 12 of 14 Fibrodysplasia Ossificans Progressiva (FOP)patients. One of the remaining patients had a previously reported allele c.1067G>A; p.G356D in the 9th exon and the second allele c.983G>A; p.G328E in the 8th exon of ACVR1.

  9. clinically aggressive stem cell-like subtype of hepatocellular carcinoma characterized by miR (show MLXIP Antibodies)-148a-ACVR1-BMP-Wnt (show WNT2 Antibodies) circuit

  10. compounds demonstrated consistent binding to a panel of mutant and wild-type ALK2 proteins

Activin Receptor Type I (ACRV1) Antigen Profile

Protein Summary

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling\; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.

Gene names and symbols associated with ACRV1

  • activin A receptor, type 1 (Acvr1) antibody
  • activin A receptor, type I (ACVR1) antibody
  • activin A receptor, type I (Acvr1) antibody
  • ActR-I antibody
  • ActR-IA antibody
  • ACTRI antibody
  • ActRIA antibody
  • Acvr antibody
  • ACVR1A antibody
  • ACVRLK2 antibody
  • Alk-2 antibody
  • ALK2 antibody
  • Alk8 antibody
  • D330013D15Rik antibody
  • FOP antibody
  • SKR1 antibody
  • Tsk7L antibody
  • TSRI antibody

Protein level used designations for ACRV1

TGF-B superfamily receptor type I , TSK-7L , TSR-I , activin receptor type I , activin receptor type-1 , serine/threonine-protein kinase receptor R1 , activin A receptor, type II-like kinase 2 , activin receptor-like kinase 2 , hydroxyalkyl-protein kinase , ACTR-I , SKR1 , activin A receptor, type 1 , activin type I receptor , type I TGF B receptor , activin A receptor, type I , activin receptor type IA

GENE ID SPECIES
11477 Mus musculus
90 Homo sapiens
478757 Canis lupus familiaris
338068 Bos taurus
79558 Rattus norvegicus
395246 Gallus gallus
443161 Ovis aries
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