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ACADM encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. Additionally we are shipping Acyl-CoA Dehydrogenase, C-4 To C-12 Straight Chain Proteins (16) and Acyl-CoA Dehydrogenase, C-4 To C-12 Straight Chain Kits (5) and many more products for this protein.
Showing 10 out of 104 products:
Human Polyclonal ACADM Primary Antibody for IHC, ELISA - ABIN184850
Matsubara, Kraus, Yang-Feng, Francke, Rosenberg, Tanaka: Molecular cloning of cDNAs encoding rat and human medium-chain acyl-CoA dehydrogenase and assignment of the gene to human chromosome 1. in Proceedings of the National Academy of Sciences of the United States of America 1986
Human Polyclonal ACADM Primary Antibody for ELISA, WB - ABIN559743
Rennison, McElfresh, Okere, Patel, Foster, Patel, Stoll, Minkler, Fujioka, Hoit, Young, Hoppel, Chandler: Enhanced acyl-CoA dehydrogenase activity is associated with improved mitochondrial and contractile function in heart failure. in Cardiovascular research 2008
Human Polyclonal ACADM Primary Antibody for EIA, FACS - ABIN452704
Ferreira, Orlandi, Oliveira, Malta, Caxito, Gomes, Valadares, Godard: A985G mutation incidence in the medium-chain acyl-CoA dehydrogenase (MCAD) gene in Brazil. in Genetics and molecular research : GMR 2009
Cow (Bovine) Polyclonal ACADM Primary Antibody for WB - ABIN2777594
Parker: Binding of the human \electron transferring flavoprotein\" (ETF) to the medium chain acyl-CoA dehydrogenase (MCAD) involves an arginine and histidine residue." in Journal of enzyme inhibition and medicinal chemistry 2003
Human Polyclonal ACADM Primary Antibody for IHC (p), WB - ABIN374273
Powelka, Seth, Virbasius, Kiskinis, Nicoloro, Guilherme, Tang, Straubhaar, Cherniack, Parker, Czech: Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional corepressor RIP140 in mouse adipocytes. in The Journal of clinical investigation 2006
Cow (Bovine) Polyclonal ACADM Primary Antibody for WB - ABIN2777593
Nichols, Saavedra-Matiz, Pass, Caggana: Novel mutations causing medium chain acyl-CoA dehydrogenase deficiency: under-representation of the common c.985 A > G mutation in the New York state population. in American journal of medical genetics. Part A 2008
Study determined three mutations (p.R53C, p.R281S and p.G362E) in MCAD protein predisposing for MCAD deficiency which seems to be unique to Japanese population.
our study demonstrates that not all mutations identified in children with abnormal NBS (show NBN Antibodies) profiles suggestive of MCAD deficiency result in a total loss in MCAD activity and function
mutations in the ACADM gene lower the temperature threshold at which medium-chain acyl-CoA dehydrogenase deficiency loss-of-function occurs.
Segregation studies in the Gypsy families showed that 93/123 relatives were carriers of the acyl-coenzyme A (show SOAT2 Antibodies) dehydrogenase G985 allele, suggesting its high prevalence in this ethnic group.
Identify an ACADM founder mutation for MCADD in Saudi Arabian population.
This supports that c.1161A>G is a functional SNP, which leads to higher MCAD expression, perhaps due to improved splicing. This study is a proof of principle that synonymous SNPs are not neutral.
medium chain acyl-CoA dehydrogenase involve in the metabolism of phenylbutyrate.
Subjects with variant ACADM genotypes and residual MCAD enzyme activities <10% should be considered to have the same risks as patients with classical ACADM genotypes
The octanoyl-CoA oxidation rate, therefore, allows a risk assessment at birth and the identification of new ACADM genotypes associated with asymptomatic disease variants.
A novel variant in the Medium-Chain Acyl-CoA Dehydrogenase (MCAD) gene was identified in a Greek cohort of neonates with suspected MCAD deficiency.
ACADM and ALDH2 (show ALDH2 Antibodies) were predicted to be the target genes of miR (show MYLIP Antibodies)-224
Investigation of ACADM in relation to fat deposition traits.
Investigation of structure of enzyme (from kidney) complexed with FAD analogs (e.g., 8-NH2-FAD) and acyl-CoA (e.g., octanoyl-CoA).
the transcriptional regulatory circuits involved in the control of MCAD gene expression under hypoxic conditions are modulated by upstream factors that are sensitive to the levels of oxygen
MCAD is reduced in liver, heart & kidney in lipopolysaccharide-induced acute phase response; binding liver nuclear extracts to ERRalpha (show ESRRA Antibodies) response element found in promoter region of MCAD was decreased during APR (show PMAIP1 Antibodies), suggesting less transcription of MCAD
The MCAD-/- mice developed an organic aciduria and fatty liver, and showed profound cold intolerance at 4 degrees C with prior fasting.
MCAD deficiency in mice leads to specific changes in hepatic carbohydrate management on exposure to metabolic stress.
A high-fat diet increases adiposity but maintains mitochondrial oxidative enzymes (MCAD/citrate synthase (show CS Antibodies)) without affecting development of heart failure with pressure overload.
This gene encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Defects in this gene cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
acyl-CoA dehydrogenase, C-4 to C-12 straight chain
, medium-chain acyl-CoA dehydrogenase
, acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain
, medium-chain specific acyl-CoA dehydrogenase, mitochondrial-like
, medium-chain specific acyl-CoA dehydrogenase, mitochondrial
, C-4 to C-12 straight chain acyl-coenzyme A dehydrogenase
, acyl-coenzyme A dehydrogenase, C-4 to C-12 straight chain
, Acyl-Coenzyme A dehydrogenase C-4 to C-12 straight-chain
, Acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight-chain
, acyl-Coenzyme A dehydrogenase, medium chain
, acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain, nuclear gene encoding mitochondrial protein