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Acyl-CoA Synthetase Short-Chain Family Member 2 Proteins (ACSS2)

ACSS2 encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. Additionally we are shipping ACSS2 Antibodies (86) and ACSS2 Kits (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ACSS2 55902 Q9NR19
ACSS2 60525 Q9QXG4
Rat ACSS2 ACSS2 311569  
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Top ACSS2 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

ACSS2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Acyl-CoA Synthetase Short-Chain Family Member 2 (ACSS2) Interaction Partners

Human Acyl-CoA Synthetase Short-Chain Family Member 2 (ACSS2) interaction partners

  1. Loss of ACSS2 expression is associated with with gastric cancer.

  2. Study revealed that the activity of acetyl-CoA synthetase 2 (show ACSS1 Proteins) (ACSS2) contributes to cancer cell growth under low-oxygen and lipid-depleted conditions.

  3. Observations suggest that ACSS2 is expressed to a significant extent in particular tumor types, including triple-negative breast cancers.

  4. Study shows that ACSS2 is upregulated in the human orthotopic tumor and primary human tumors, as well as a murine glioma model; the tumors do not oxidize [U-(13)C]glutamine (show GFPT1 Proteins). In vivo oxidation of [1,2-(13)C]acetate was validated in brain tumor patients and was correlated with expression of acetyl-CoA synthetase enzyme 2, ACSS2.

  5. During hypoxia, ACSS2 modulates interactions (show LPCAT2 Proteins)of the acetylase/coactivator CBP with the stress-responsive transcription fa (show CREBBP Proteins)ctor, HIF-2. These int (show CREBBP Proteins)eractions include acetylation of HIF-2 by CBP as well as stable HIF-2/CBP comple (show EPO Proteins)x formation, both of which are required for maximal HIF-2 signaling. Thus, ACSS2 links changes in metabolism that occur during stress with activation of a selective nuclear signaling pathway.

  6. Ritonavir (at 100 mg once daily and 100 mg twice daily significantly down-regulated acyl-CoA synthetase short-chain family member 2 in 20 healthy individuals.

  7. Because the activity of a bacterial ortholog of AceCS2 (show ACSS1 Proteins), called ACS (show PLA2G15 Proteins), is controlled via deacetylation by a bacterial sirtuin (show SIRT1 Proteins) protein, our observation highlights the conservation of a metabolic regulatory pathway from bacteria to humans

  8. The patterns of (18)F-FDG (show SMUG1 Proteins) and (11)C-acetate uptake seemed to complement each other in both human HCC (show FAM126A Proteins) and HCC (show FAM126A Proteins) cell lines.

Mouse (Murine) Acyl-CoA Synthetase Short-Chain Family Member 2 (ACSS2) interaction partners

  1. Study revealed that the activity of acetyl-CoA synthetase 2 (show ACSS1 Proteins) (ACSS2) contributes to cancer cell growth under low-oxygen and lipid-depleted conditions.

  2. Study reports evidence that the nucleocytosolic ACSS2 enzyme is of critical importance for mammalian cells to utilize acetate as a source of acetyl-CoA (show LPCAT1 Proteins), and that mice lacking this enzyme exhibit a substantial reduction in tumor burden in two genetic models of liver cancer.

  3. Study shows that ACSS2 is upregulated in the human orthotopic tumor and primary human tumors, as well as a murine glioma model; the tumors do not oxidize [U-(13)C]glutamine (show GFPT1 Proteins). In vivo oxidation of [1,2-(13)C]acetate was validated in brain tumor patients and was correlated with expression of acetyl-CoA synthetase (show Acsl1 Proteins) enzyme 2, ACSS2.

  4. Acss2 generates a specific pool of acetyl CoA (show LPCAT1 Proteins) during hypoxia that modulates interactions of the acetylase/coactivator Cbp (show CREBBP Proteins) (also known as Crebbp (show CREBBP Proteins)) with the stress-responsive transcription factor, Hif-2. Because erythropoietin (show EPO Proteins) is a Hif-2 target gene, red blood cell production in mice is also regulated by Acss2. Recovery from anemia is accelerated by administering acetate, although this requires the presence of Acss2.

  5. Acetyl CoA synthetase-1 (AceCS1) is mainly expressed in oligodendrocytes in the rat brain. It is located both in cytosol and nucleus of mammalian cells.

  6. Expression of cytosolic acetyl-CoA synthetase gene in mice is developmentally regulated

  7. ACSS2 might play a buffering role in tumor acetyl-CoA (show LPCAT1 Proteins)/acetate metabolism

ACSS2 Protein Profile

Protein Summary

This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with ACSS2

  • acyl-CoA synthetase short-chain family member 2 (ACSS2)
  • acyl-CoA synthetase short-chain family member 2 (acss2)
  • acyl-CoA synthetase short-chain family member 2 (Acss2)
  • 1110017C11Rik protein
  • ACAS protein
  • Acas1 protein
  • Acas2 protein
  • ACECS protein
  • AceCS1 protein
  • ACS protein
  • Acs1 protein
  • ACSA protein
  • dJ1161H23.1 protein
  • wu:fa04c03 protein
  • wu:fj80b06 protein
  • wu:fj80h04 protein
  • zgc:92200 protein

Protein level used designations for ACSS2

acyl-CoA synthetase short-chain family member 2 , acetyl-coenzyme A synthetase, cytoplasmic , acetyl-coenzyme A synthetase, cytoplasmic-like , fa04c03 , fj80b06 , fj80h04 , acetyl-CoA synthetase 2 , acetate thiokinase , acetate-CoA ligase , acetyl-Coenzyme A synthetase 2 (ADP forming) , acyl-activating enzyme , cytoplasmic acetyl-coenzyme A synthetase , ACS , aceCS , acetate--CoA ligase , acetyl-CoA synthetase 1 , acetyl-Coenzyme A synthetase 1 (AMP forming) , acetyl-Coenzyme A synthetase 2 (AMP forming)

GENE ID SPECIES
477205 Canis lupus familiaris
506459 Bos taurus
100032395 Monodelphis domestica
100054562 Equus caballus
100179555 Ciona intestinalis
100211402 Hydra magnipapillata
100224916 Taeniopygia guttata
100455504 Pongo abelii
100481825 Ailuropoda melanoleuca
419158 Gallus gallus
436914 Danio rerio
458441 Pan troglodytes
706703 Macaca mulatta
780456 Ovis aries
100153866 Sus scrofa
100346003 Oryctolagus cuniculus
100411267 Callithrix jacchus
100542964 Meleagris gallopavo
100604921 Nomascus leucogenys
55902 Homo sapiens
60525 Mus musculus
311569 Rattus norvegicus
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