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anti-Acyl-Coenzyme A Dehydrogenase, Medium Chain (ACADM) Antibodies

catalyzes the alpha, beta-dehydrogenation of acyl-CoA esters in fatty acid metabolism.

list all antibodies Gene Name GeneID UniProt
ACADM 34 P11310
ACADM 24158 P08503
ACADM 11364 P45952
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Top anti-Acyl-Coenzyme A Dehydrogenase, Medium Chain Antibodies at antibodies-online.com

Showing 2 out of 2 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 14 Days
$201.19
Details
Human Rabbit Un-conjugated ELISA, WB   100 μg Log in to see 2 to 3 Days
$302.50
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ACADM Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human


Rat (Rattus)


Mouse (Murine)


More Antibodies against Acyl-Coenzyme A Dehydrogenase, Medium Chain Interaction Partners

Human Acyl-Coenzyme A Dehydrogenase, Medium Chain (ACADM) interaction partners

  1. our study demonstrates that not all mutations identified in children with abnormal NBS (show NBN Antibodies) profiles suggestive of MCAD deficiency result in a total loss in MCAD activity and function

  2. mutations in the ACADM gene lower the temperature threshold at which medium-chain acyl-CoA dehydrogenase deficiency loss-of-function occurs.

  3. Segregation studies in the Gypsy families showed that 93/123 relatives were carriers of the acyl-coenzyme A (show SOAT2 Antibodies) dehydrogenase G985 allele, suggesting its high prevalence in this ethnic group.

  4. Identify an ACADM founder mutation for MCADD in Saudi Arabian population.

  5. This supports that c.1161A>G is a functional SNP, which leads to higher MCAD expression, perhaps due to improved splicing. This study is a proof of principle that synonymous SNPs are not neutral.

  6. medium chain acyl-CoA dehydrogenase involve in the metabolism of phenylbutyrate.

  7. Subjects with variant ACADM genotypes and residual MCAD enzyme activities <10% should be considered to have the same risks as patients with classical ACADM genotypes

  8. The octanoyl-CoA oxidation rate, therefore, allows a risk assessment at birth and the identification of new ACADM genotypes associated with asymptomatic disease variants.

  9. A novel variant in the Medium-Chain Acyl-CoA Dehydrogenase (MCAD) gene was identified in a Greek cohort of neonates with suspected MCAD deficiency.

  10. The mutation in Medium-chain acyl-CoA dehydrogenase deficiency is the first report of the c.461T>G mutation in the acyl-CoA dehydrogenase gene.

Mouse (Murine) Acyl-Coenzyme A Dehydrogenase, Medium Chain (ACADM) interaction partners

  1. the transcriptional regulatory circuits involved in the control of MCAD gene expression under hypoxic conditions are modulated by upstream factors that are sensitive to the levels of oxygen

  2. MCAD is reduced in liver, heart & kidney in lipopolysaccharide-induced acute phase response; binding liver nuclear extracts to ERRalpha (show ESRRA Antibodies) response element found in promoter region of MCAD was decreased during APR (show PMAIP1 Antibodies), suggesting less transcription of MCAD

  3. The MCAD-/- mice developed an organic aciduria and fatty liver, and showed profound cold intolerance at 4 degrees C with prior fasting.

  4. MCAD deficiency in mice leads to specific changes in hepatic carbohydrate management on exposure to metabolic stress.

  5. A high-fat diet increases adiposity but maintains mitochondrial oxidative enzymes (MCAD/citrate synthase (show CS Antibodies)) without affecting development of heart failure with pressure overload.

Acyl-Coenzyme A Dehydrogenase, Medium Chain (ACADM) Antigen Profile

Protein Summary

This gene encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Defects in this gene cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with ACADM

  • acyl-CoA dehydrogenase, C-4 to C-12 straight chain (ACADM) antibody
  • acyl-CoA dehydrogenase, C-4 to C-12 straight chain (Acadm) antibody
  • acyl-Coenzyme A dehydrogenase, medium chain (Acadm) antibody
  • ACAD1 antibody
  • AU018656 antibody
  • MCAD antibody
  • MCADH antibody

Protein level used designations for ACADM

acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain , medium-chain specific acyl-CoA dehydrogenase, mitochondrial , Acyl-Coenzyme A dehydrogenase C-4 to C-12 straight-chain , Acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight-chain , acyl-Coenzyme A dehydrogenase, medium chain , medium-chain acyl-CoA dehydrogenase

GENE ID SPECIES
34 Homo sapiens
24158 Rattus norvegicus
11364 Mus musculus
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