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ACSS2 encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. Additionally we are shipping ACSS2 Proteins (5) and many more products for this protein.
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In a Honduran population, the odds of having nonsyndromic cleft lip/palate (NSCLP) among carriers of the ACSS2 variant was 4.0 with a carrier frequency of 7.1% in unrelated affected and 1.9% in unrelated unaffected individuals. In a Colombian population, the odds of having NSCLP among carriers of the ACSS2 variant was 2.6 with a carrier frequency of 10.0% in unrelated affected and 4.1% in unrelated unaffected individuals.
In the nucleus, ACSS2 binds to transcription factor EB (show TFEB Antibodies) and translocates to lysosomal and autophagy gene promoter regions, where ACSS2 incorporates acetate generated from histone acetylation turnover to locally produce acetyl-CoA (show LPCAT2 Antibodies) for histone H3 (show HIST3H3 Antibodies) acetylation in these regions and promote lysosomal biogenesis, autophagy, cell survival, and brain tumorigenesis.
ACSS2 is essential for glucose-independent acetate-mediated cell survival and tumor growth.
Loss of ACSS2 expression is associated with with gastric cancer.
Study revealed that the activity of acetyl-CoA synthetase 2 (show ACSS1 Antibodies) (ACSS2) contributes to cancer cell growth under low-oxygen and lipid-depleted conditions.
Observations suggest that ACSS2 is expressed to a significant extent in particular tumor types, including triple-negative breast cancers.
Study shows that ACSS2 is upregulated in the human orthotopic tumor and primary human tumors, as well as a murine glioma model; the tumors do not oxidize [U-(13)C]glutamine (show GFPT1 Antibodies). In vivo oxidation of [1,2-(13)C]acetate was validated in brain tumor patients and was correlated with expression of acetyl-CoA synthetase enzyme 2, ACSS2.
During hypoxia, ACSS2 modulates interactions (show LPCAT2 Antibodies)of the acetylase/coactivator CBP with the stress-responsive transcription fa (show CREBBP Antibodies)ctor, HIF-2. These int (show CREBBP Antibodies)eractions include acetylation of HIF-2 by CBP as well as stable HIF-2/CBP comple (show EPO Antibodies)x formation, both of which are required for maximal HIF-2 signaling. Thus, ACSS2 links changes in metabolism that occur during stress with activation of a selective nuclear signaling pathway.
Ritonavir (at 100 mg once daily and 100 mg twice daily significantly down-regulated acyl-CoA synthetase short-chain family member 2 in 20 healthy individuals.
Because the activity of a bacterial ortholog of AceCS2 (show ACSS1 Antibodies), called ACS (show PLA2G15 Antibodies), is controlled via deacetylation by a bacterial sirtuin (show SIRT1 Antibodies) protein, our observation highlights the conservation of a metabolic regulatory pathway from bacteria to humans
results reveal a connection between cellular metabolism, gene regulation, and neural plasticity and establish a link between acetyl-CoA (show LPCAT1 Antibodies) generation 'on-site' at chromatin for histone acetylation and the transcription of key neuronal genes.
Study reports evidence that the nucleocytosolic ACSS2 enzyme is of critical importance for mammalian cells to utilize acetate as a source of acetyl-CoA (show LPCAT1 Antibodies), and that mice lacking this enzyme exhibit a substantial reduction in tumor burden in two genetic models of liver cancer.
Study shows that ACSS2 is upregulated in the human orthotopic tumor and primary human tumors, as well as a murine glioma model; the tumors do not oxidize [U-(13)C]glutamine (show GFPT1 Antibodies). In vivo oxidation of [1,2-(13)C]acetate was validated in brain tumor patients and was correlated with expression of acetyl-CoA synthetase (show Acsl1 Antibodies) enzyme 2, ACSS2.
Acss2 generates a specific pool of acetyl CoA (show LPCAT1 Antibodies) during hypoxia that modulates interactions of the acetylase/coactivator Cbp (show CREBBP Antibodies) (also known as Crebbp (show CREBBP Antibodies)) with the stress-responsive transcription factor, Hif-2. Because erythropoietin (show EPO Antibodies) is a Hif-2 target gene, red blood cell production in mice is also regulated by Acss2. Recovery from anemia is accelerated by administering acetate, although this requires the presence of Acss2.
Acetyl CoA synthetase-1 (AceCS1) is mainly expressed in oligodendrocytes in the rat brain. It is located both in cytosol and nucleus of mammalian cells.
Expression of cytosolic acetyl-CoA synthetase gene in mice is developmentally regulated
ACSS2 might play a buffering role in tumor acetyl-CoA (show LPCAT1 Antibodies)/acetate metabolism
This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Alternative splicing results in multiple transcript variants.
acyl-CoA synthetase short-chain family member 2
, acetyl-coenzyme A synthetase, cytoplasmic
, acetyl-coenzyme A synthetase, cytoplasmic-like
, acetyl-CoA synthetase 2
, acetate thiokinase
, acetate-CoA ligase
, acetyl-Coenzyme A synthetase 2 (ADP forming)
, acyl-activating enzyme
, cytoplasmic acetyl-coenzyme A synthetase
, acetate--CoA ligase
, acetyl-CoA synthetase 1
, acetyl-Coenzyme A synthetase 1 (AMP forming)
, acetyl-Coenzyme A synthetase 2 (AMP forming)