You are viewing an incomplete version of our website. Please click to reload the website as full version.

anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) Antibodies

The protein encoded by APPL1 has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. Additionally we are shipping Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
APPL1 26060 Q9UKG1
APPL1 72993 Q8K3H0
APPL1 290537  
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 Antibodies at antibodies-online.com

Showing 10 out of 59 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-APPL1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:... 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Goat Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Goat Un-conjugated ELISA, WB ABIN190879 (0.5µg/ml) staining of 1) Rat Aortic Smooth Muscle cell lys... 100 μg Log in to see 4 to 5 Days
$318.20
Details
Mouse Rabbit Un-conjugated ICC, IF, IHC (p), IP, WB 50 μL Log in to see 5 to 6 Days
$486.22
Details
Human Rabbit Un-conjugated ELISA, WB   100 μg Log in to see 2 to 3 Days
$275.00
Details
Human Rabbit Un-conjugated IHC (p), WB Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 8 to 10 Days
$676.50
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-APPL antibody, Western blotting WB: HELA Cell Lysate 100 μg Log in to see 4 to 6 Days
$200.00
Details
Rat Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Human Goat Un-conjugated ELISA, WB 100 μg Log in to see 8 to 10 Days
$595.83
Details
Human Rabbit Un-conjugated IF, WB 50 μL Log in to see 8 to 10 Days
$676.50
Details

APPL1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human , , , ,
, ,
Mouse (Murine) , , , ,
,
Rat (Rattus) , , , ,
,

Top referenced anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 Antibodies

  1. Mouse (Murine) APPL1 Primary Antibody for ICC, IF - ABIN1042584 : Mitsuuchi, Johnson, Sonoda, Tanno, Golemis, Testa: Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2. in Oncogene 1999 (PubMed)
    Show all 5 references for ABIN1042584

  2. Human Polyclonal APPL1 Primary Antibody for WB - ABIN2785912 : McCrea, Paradise, Tomasini, Addis, Melis, De Matteis, De Camilli: All known patient mutations in the ASH-RhoGAP domains of OCRL affect targeting and APPL1 binding. in Biochemical and biophysical research communications 2008 (PubMed)

  3. Human Polyclonal APPL1 Primary Antibody for ELISA, WB - ABIN1451205 : Matsuoka, Ballif, Smogorzewska, McDonald, Hurov, Luo, Bakalarski, Zhao, Solimini, Lerenthal, Shiloh, Gygi, Elledge: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. in Science (New York, N.Y.) 2007 (PubMed)

  4. Human Polyclonal APPL1 Primary Antibody for ELISA, WB - ABIN190879 : Mao, Kikani, Riojas, Langlais, Wang, Ramos, Fang, Christ-Roberts, Hong, Kim, Liu, Dong: APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function. in Nature cell biology 2006 (PubMed)

More Antibodies against Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 Interaction Partners

Human Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) interaction partners

  1. APPL1 endosomes represent a distinct population of Rab5 (show RAB5A Antibodies)-positive sorting endosomes.

  2. article provides evidence that GG genotype and G carrier (CG+GG) genotypes of the rs4640525 polymorphism in the APPL1 gene may be suitable susceptibility biomarkers for NAFLD (show TSC2 Antibodies)

  3. Two loss-of-function mutations in APPL1, identified by means of whole-exome sequencing, found in two large families with a high prevalence of Familial Diabetes Mellitus.

  4. A role for APPL1 in TLR3 (show TLR3 Antibodies)/4-dependent TBK1 (show TBK1 Antibodies) and IKKepsilon (show IKBKE Antibodies) activation in macrophages.

  5. ATM (show ATM Antibodies) is the central modulator of APPL-mediated effects on radiosensitivity and DNA repair.

  6. APPL1 sensitizes insulin (show INS Antibodies) signaling by acting at a site downstream of the IR. Study uncovers a mechanism regulating insulin (show INS Antibodies) signaling and crosstalk between the insulin (show INS Antibodies) and adiponectin (show ADIPOQ Antibodies) pathways.

  7. APPL1 is a positive regulator of Dvl2 (show DVL2 Antibodies)-dependent transcriptional activity of AP-1 (show FOSB Antibodies).

  8. It concludes that APPL1(PH) binding to BAR domain and Reptin (show RUVBL2 Antibodies) is mutually exclusive which regulates the nucleocytoplasmic shuttling of Reptin (show RUVBL2 Antibodies).

  9. The activated EGF receptor (show EGFR Antibodies) enters distinct sub-populations of SNX15 (show SNX15 Antibodies)- and APPL1-labelled peripheral endocytic vesicles.

  10. C-APPL1/A-APPL2 (show APLP2 Antibodies) allele combination is associated with non-alcoholic fatty liver disease occurrence, with a more severe hepatic steatosis grade and with a reduced adiponectin (show ADIPOQ Antibodies) cytoprotective effect on liver.

Mouse (Murine) Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) interaction partners

  1. Appl1/2-null mouse embryonic fibroblasts exhibited defects in HGF (show HGF Antibodies)-induced Akt (show AKT1 Antibodies) activation, migration, and invasion.

  2. In experimental high glucose condition APPL1 acts as a protective factor against podocytes injury through regulating AMPK (show PRKAA1 Antibodies) signaling.

  3. A role for APPL1 in TLR3 (show TLR3 Antibodies)/4-dependent TBK1 (show TBK1 Antibodies) and IKKepsilon (show IKBKE Antibodies) activation in macrophages.

  4. APPL1 sensitizes insulin (show INS Antibodies) signaling by acting at a site downstream of the IR. Study uncovers a mechanism regulating insulin (show INS Antibodies) signaling and crosstalk between the insulin (show INS Antibodies) and adiponectin (show ADIPOQ Antibodies) pathways.

  5. Study demonstrates the roles of APPL1 in regulating GSIS and mitochondrial function in pancreatic beta cells, which implicates APPL1 as a therapeutic target in the treatment of type 2 diabetes.

  6. APPL1 transgenic mice exhibit improved peripheral metabolism, reduced cardiac lipotoxicity, and improved insulin (show INS Antibodies) sensitivity.

  7. Our findings demonstrate that exercise training performed concomitantly to a high-fat diet reduces the degree of insulin (show INS Antibodies) resistance and improves adipoR1 (show ADIPOR1 Antibodies)-2/APPL1 protein levels in the hepatic, adipose, and skeletal muscle tissue

  8. APPL1 contributes to connecting synaptic NMDA receptors with the intracellular phosphoinositide 3-kinase /Akt (show AKT1 Antibodies) cascade in neurons.

  9. Reduced APPL1 expression in pancreatic islets may serve as a pathological link that couples insulin (show INS Antibodies) resistance to beta-cell dysfunction in type 2 diabetes.

  10. Endurance training was able to increase APPL1 expression.

Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) Antigen Profile

Protein Summary

The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.

Gene names and symbols associated with APPL1

  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (APPL1) antibody
  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (Appl1) antibody
  • 2900057D21Rik antibody
  • 7330406P05Rik antibody
  • AI585782 antibody
  • APPL antibody
  • AW209077 antibody
  • BB022931 antibody
  • C88264 antibody
  • DIP13 antibody
  • DIP13alpha antibody
  • RGD1309388 antibody

Protein level used designations for APPL1

AKT2 interactor , DCC-interacting protein 13-alpha , adapter protein containing PH domain, PTB domain and leucine zipper motif 1 , adaptor protein containing pH domain, PTB domain and leucine zipper motif 1 , dip13-alpha , signaling adaptor protein DIP13alpha , DIP13 alpha , adaptor protein APPL like

GENE ID SPECIES
100058653 Equus caballus
26060 Homo sapiens
484716 Canis lupus familiaris
517850 Bos taurus
72993 Mus musculus
290537 Rattus norvegicus
100188978 Sus scrofa
Selected quality suppliers for anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) Antibodies
Did you look for something else?