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Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) ELISA Kits

The protein encoded by APPL1 has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. Additionally we are shipping Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 Antibodies (61) and Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 Proteins (5) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human APPL1 APPL1 26060 Q9UKG1
Anti-Mouse APPL1 APPL1 72993 Q8K3H0
Anti-Rat APPL1 APPL1 290537  
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More ELISA Kits for Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 Interaction Partners

Human Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) interaction partners

  1. Low expression of APPL1 is associated with metastasis in prostate cancer.

  2. APPL1 endosomes represent a distinct population of Rab5 (show RAB5A ELISA Kits)-positive sorting endosomes.

  3. article provides evidence that GG genotype and G carrier (CG+GG) genotypes of the rs4640525 polymorphism in the APPL1 gene may be suitable susceptibility biomarkers for NAFLD (show TSC2 ELISA Kits)

  4. Two loss-of-function mutations in APPL1, identified by means of whole-exome sequencing, found in two large families with a high prevalence of Familial Diabetes Mellitus.

  5. A role for APPL1 in TLR3 (show TLR3 ELISA Kits)/4-dependent TBK1 (show TBK1 ELISA Kits) and IKKepsilon (show IKBKE ELISA Kits) activation in macrophages.

  6. ATM (show ATM ELISA Kits) is the central modulator of APPL-mediated effects on radiosensitivity and DNA repair.

  7. APPL1 sensitizes insulin (show INS ELISA Kits) signaling by acting at a site downstream of the IR. Study uncovers a mechanism regulating insulin (show INS ELISA Kits) signaling and crosstalk between the insulin (show INS ELISA Kits) and adiponectin (show ADIPOQ ELISA Kits) pathways.

  8. APPL1 is a positive regulator of Dvl2 (show DVL2 ELISA Kits)-dependent transcriptional activity of AP-1 (show FOSB ELISA Kits).

  9. It concludes that APPL1(PH) binding to BAR domain and Reptin (show RUVBL2 ELISA Kits) is mutually exclusive which regulates the nucleocytoplasmic shuttling of Reptin (show RUVBL2 ELISA Kits).

  10. The activated EGF receptor (show EGFR ELISA Kits) enters distinct sub-populations of SNX15 (show SNX15 ELISA Kits)- and APPL1-labelled peripheral endocytic vesicles.

Mouse (Murine) Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) interaction partners

  1. Appl1/2-null mouse embryonic fibroblasts exhibited defects in HGF (show HGF ELISA Kits)-induced Akt (show AKT1 ELISA Kits) activation, migration, and invasion.

  2. In experimental high glucose condition APPL1 acts as a protective factor against podocytes injury through regulating AMPK (show PRKAA1 ELISA Kits) signaling.

  3. A role for APPL1 in TLR3 (show TLR3 ELISA Kits)/4-dependent TBK1 (show TBK1 ELISA Kits) and IKKepsilon (show IKBKE ELISA Kits) activation in macrophages.

  4. APPL1 sensitizes insulin (show INS ELISA Kits) signaling by acting at a site downstream of the IR. Study uncovers a mechanism regulating insulin (show INS ELISA Kits) signaling and crosstalk between the insulin (show INS ELISA Kits) and adiponectin (show ADIPOQ ELISA Kits) pathways.

  5. Study demonstrates the roles of APPL1 in regulating GSIS and mitochondrial function in pancreatic beta cells, which implicates APPL1 as a therapeutic target in the treatment of type 2 diabetes.

  6. APPL1 transgenic mice exhibit improved peripheral metabolism, reduced cardiac lipotoxicity, and improved insulin (show INS ELISA Kits) sensitivity.

  7. Our findings demonstrate that exercise training performed concomitantly to a high-fat diet reduces the degree of insulin (show INS ELISA Kits) resistance and improves adipoR1 (show ADIPOR1 ELISA Kits)-2/APPL1 protein levels in the hepatic, adipose, and skeletal muscle tissue

  8. APPL1 contributes to connecting synaptic NMDA receptors with the intracellular phosphoinositide 3-kinase /Akt (show AKT1 ELISA Kits) cascade in neurons.

  9. Reduced APPL1 expression in pancreatic islets may serve as a pathological link that couples insulin (show INS ELISA Kits) resistance to beta-cell dysfunction in type 2 diabetes.

  10. Endurance training was able to increase APPL1 expression.

Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) Antigen Profile

Antigen Summary

The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.

Gene names and symbols associated with APPL1

  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (APPL1) antibody
  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (Appl1) antibody
  • 2900057D21Rik antibody
  • 7330406P05Rik antibody
  • AI585782 antibody
  • APPL antibody
  • AW209077 antibody
  • BB022931 antibody
  • C88264 antibody
  • DIP13 antibody
  • DIP13alpha antibody
  • RGD1309388 antibody

Protein level used designations for APPL1

AKT2 interactor , DCC-interacting protein 13-alpha , adapter protein containing PH domain, PTB domain and leucine zipper motif 1 , adaptor protein containing pH domain, PTB domain and leucine zipper motif 1 , dip13-alpha , signaling adaptor protein DIP13alpha , DIP13 alpha , adaptor protein APPL like

GENE ID SPECIES
100058653 Equus caballus
26060 Homo sapiens
484716 Canis lupus familiaris
517850 Bos taurus
72993 Mus musculus
290537 Rattus norvegicus
100188978 Sus scrofa
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