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Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 Proteins (APPL1)

The protein encoded by APPL1 has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. Additionally we are shipping Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 Antibodies (61) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
APPL1 26060 Q9UKG1
APPL1 72993 Q8K3H0
Rat APPL1 APPL1 290537  
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Top Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

APPL1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) Interaction Partners

Human Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) interaction partners

  1. Low expression of APPL1 is associated with metastasis in prostate cancer.

  2. APPL1 endosomes represent a distinct population of Rab5 (show RAB5A Proteins)-positive sorting endosomes.

  3. article provides evidence that GG genotype and G carrier (CG+GG) genotypes of the rs4640525 polymorphism in the APPL1 gene may be suitable susceptibility biomarkers for NAFLD

  4. Two loss-of-function mutations in APPL1, identified by means of whole-exome sequencing, found in two large families with a high prevalence of Familial Diabetes Mellitus.

  5. A role for APPL1 in TLR3 (show TLR3 Proteins)/4-dependent TBK1 (show TBK1 Proteins) and IKKepsilon (show IKBKE Proteins) activation in macrophages.

  6. ATM (show ATM Proteins) is the central modulator of APPL-mediated effects on radiosensitivity and DNA repair.

  7. APPL1 sensitizes insulin (show INS Proteins) signaling by acting at a site downstream of the IR. Study uncovers a mechanism regulating insulin (show INS Proteins) signaling and crosstalk between the insulin (show INS Proteins) and adiponectin (show ADIPOQ Proteins) pathways.

  8. APPL1 is a positive regulator of Dvl2 (show DVL2 Proteins)-dependent transcriptional activity of AP-1 (show FOSB Proteins).

  9. It concludes that APPL1(PH) binding to BAR domain and Reptin (show RUVBL2 Proteins) is mutually exclusive which regulates the nucleocytoplasmic shuttling of Reptin (show RUVBL2 Proteins).

  10. The activated EGF receptor (show EGFR Proteins) enters distinct sub-populations of SNX15 (show SNX15 Proteins)- and APPL1-labelled peripheral endocytic vesicles.

Mouse (Murine) Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) interaction partners

  1. Appl1/2-null mouse embryonic fibroblasts exhibited defects in HGF (show HGF Proteins)-induced Akt (show AKT1 Proteins) activation, migration, and invasion.

  2. In experimental high glucose condition APPL1 acts as a protective factor against podocytes injury through regulating AMPK (show PRKAA1 Proteins) signaling.

  3. A role for APPL1 in TLR3 (show TLR3 Proteins)/4-dependent TBK1 (show TBK1 Proteins) and IKKepsilon (show IKBKE Proteins) activation in macrophages.

  4. APPL1 sensitizes insulin (show INS Proteins) signaling by acting at a site downstream of the IR. Study uncovers a mechanism regulating insulin (show INS Proteins) signaling and crosstalk between the insulin (show INS Proteins) and adiponectin (show ADIPOQ Proteins) pathways.

  5. Study demonstrates the roles of APPL1 in regulating GSIS and mitochondrial function in pancreatic beta cells, which implicates APPL1 as a therapeutic target in the treatment of type 2 diabetes.

  6. APPL1 transgenic mice exhibit improved peripheral metabolism, reduced cardiac lipotoxicity, and improved insulin (show INS Proteins) sensitivity.

  7. Our findings demonstrate that exercise training performed concomitantly to a high-fat diet reduces the degree of insulin (show INS Proteins) resistance and improves adipoR1 (show ADIPOR1 Proteins)-2/APPL1 protein levels in the hepatic, adipose, and skeletal muscle tissue

  8. APPL1 contributes to connecting synaptic NMDA receptors with the intracellular phosphoinositide 3-kinase /Akt (show AKT1 Proteins) cascade in neurons.

  9. Reduced APPL1 expression in pancreatic islets may serve as a pathological link that couples insulin (show INS Proteins) resistance to beta-cell dysfunction in type 2 diabetes.

  10. Endurance training was able to increase APPL1 expression.

Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) Protein Profile

Protein Summary

The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.

Gene names and symbols associated with APPL1

  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (APPL1)
  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (Appl1)
  • 2900057D21Rik protein
  • 7330406P05Rik protein
  • AI585782 protein
  • APPL protein
  • AW209077 protein
  • BB022931 protein
  • C88264 protein
  • DIP13 protein
  • DIP13alpha protein
  • RGD1309388 protein

Protein level used designations for APPL1

AKT2 interactor , DCC-interacting protein 13-alpha , adapter protein containing PH domain, PTB domain and leucine zipper motif 1 , adaptor protein containing pH domain, PTB domain and leucine zipper motif 1 , dip13-alpha , signaling adaptor protein DIP13alpha , DIP13 alpha , adaptor protein APPL like

GENE ID SPECIES
100058653 Equus caballus
26060 Homo sapiens
484716 Canis lupus familiaris
517850 Bos taurus
72993 Mus musculus
290537 Rattus norvegicus
100188978 Sus scrofa
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