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anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) Antibodies

The protein encoded by APPL2 is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Additionally we are shipping Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
APPL2 362860  
APPL2 55198 Q8NEU8
APPL2 216190 Q8K3G9
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Top anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 Antibodies at antibodies-online.com

Showing 10 out of 32 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB Western blot analysis of APPL2 Antibody (N-term) Pab  pre-incubated without(lane 1) and with(lane 2) blocking peptide in NCI-H292 cell line lysate. APPL2 Antibody (N-term) (arrow) was detected using the purified Pab. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated IF, WB Western Blot analysis of APPL2 expression in transfected 293T cell line by APPL2 MaxPab polyclonal antibody.Lane 1: APPL2 transfected lysate(73.04 KDa).Lane 2: Non-transfected lysate. APPL2 MaxPab polyclonal antibody. Western Blot analysis of APPL2 expression in rat brain. 50 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated WB 400 μL Log in to see 6 Days
$457.14
Details
Human Rabbit PE ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Mouse Un-conjugated IF, ELISA, WB Detection limit for recombinant GST tagged APPL2 is 0.3 ng/ml as a capture antibody. Western Blot analysis of APPL2 expression in transfected 293T cell line by APPL2 monoclonal antibody (M06), clone 1C10.Lane 1: APPL2 transfected lysate (Predicted MW: 74.5 KDa).Lane 2: Non-transfected lysate. 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated ELISA   200 μL Log in to see 8 to 10 Days
$713.17
Details
Human Rabbit Un-conjugated ELISA, WB   200 μL Log in to see 11 to 16 Days
$532.71
Details
Human Rabbit PE ELISA, WB   200 μL Log in to see 16 Days
$710.29
Details
Human Rabbit APC ELISA, WB   200 μL Log in to see 16 Days
$710.29
Details
Human Rabbit FITC ELISA, WB   200 μL Log in to see 16 Days
$710.29
Details

APPL2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Rat (Rattus)


Human ,
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Mouse (Murine) ,


Top referenced anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 Antibodies

  1. Human Polyclonal APPL2 Primary Antibody for IF, WB - ABIN527414 : Cleasby, Lau, Polkinghorne, Patel, Leslie, Turner, Cooney, Xu, Kraegen: The adaptor protein APPL1 increases glycogen accumulation in rat skeletal muscle through activation of the PI3-kinase signalling pathway. in The Journal of endocrinology 2011 (PubMed)

More Antibodies against Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 Interaction Partners

Human Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) interaction partners

  1. ATM (show ATM Antibodies) is the central modulator of APPL (show APPL1 Antibodies)-mediated effects on radiosensitivity and DNA repair.

  2. It concludes that APPL2 (show APLP2 Antibodies)(PH) binding to BAR domain and Reptin (show RUVBL2 Antibodies) is mutually exclusive which regulates the nucleocytoplasmic shuttling of Reptin (show RUVBL2 Antibodies).

  3. C-APPL1 (show APPL1 Antibodies)/A-APPL2 (show APLP2 Antibodies) allele combination is associated with non-alcoholic fatty liver disease occurrence, with a more severe hepatic steatosis grade and with a reduced adiponectin (show ADIPOQ Antibodies) cytoprotective effect on liver.

  4. Data indicate that a high level of APPL2 (show APLP2 Antibodies) protein might enhance glioblastoma growth by maintaining low expression level of genes responsible for cell death induction.

  5. analysis of APPL1 (show APPL1 Antibodies) and APPL2 (show APLP2 Antibodies) proteins and their interaction with Rab (show HRB Antibodies)

  6. Genetic variation(s) in APPL1 (show APPL1 Antibodies)/2 may be associated with CAD (show CAD Antibodies) risk in T2DM in Chinese population.

  7. Data suggest that although annexin A2 (show ANXA2 Antibodies) is not an exclusive marker of APPL1 (show APPL1 Antibodies)/2 endosomes, it has an important function in membrane recruitment of APPL (show APPL1 Antibodies) proteins, acting in parallel to Rab5 (show RAB5A Antibodies).

  8. significant fluorescence resonance energy transfer between APPL (show APPL1 Antibodies) minimal BAR domain FRET pairs

  9. identification of a pathway directly linking the small GTPase (show RACGAP1 Antibodies) Rab5 (show RAB5A Antibodies), a key regulator of endocytosis, to signal transduction and mitogenesis via APPL1 (show APPL1 Antibodies) and APPL2 (show APLP2 Antibodies), two Rab5 (show RAB5A Antibodies) effectors

  10. The findings suggest a role for APPL1 (show APPL1 Antibodies) and APPL2 (show APLP2 Antibodies) protein as dynamic scaffolds that modulate RAB5 (show RAB5A Antibodies)-associated signaling endosomal membranes by their ability to undergo domain-mediated oligomerization, membrane targeting and phosphoinositide binding.

Mouse (Murine) Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) interaction partners

  1. Appl1 (show APPL1 Antibodies)/2-null mouse embryonic fibroblasts exhibited defects in HGF (show HGF Antibodies)-induced Akt (show AKT1 Antibodies) activation, migration, and invasion.

  2. Rab31 (show RAB31 Antibodies), with APPL2 as its effector, play a role in FcgammaR-mediated phagocytosis through PI3K/Akt (show AKT1 Antibodies) signaling in macrophages.

Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) Antigen Profile

Protein Summary

The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12\;22)(q24.1\;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome.

Gene names and symbols associated with APPL2

  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (Appl2) antibody
  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (APPL2) antibody
  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (appl2) antibody
  • amyloid beta (A4) precursor-like protein 2 (APLP2) antibody
  • APPL2 antibody
  • Dip3b antibody
  • DIP13B antibody
  • MGC84621 antibody
  • RGD1563028 antibody

Protein level used designations for APPL2

DCC-interacting protein 13-beta , adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 , amyloid beta (A4) precursor-like protein 2 , DIP13 beta , adapter protein containing PH domain, PTB domain and leucine zipper motif 2 , Dip3 beta , dip13-beta

GENE ID SPECIES
362860 Rattus norvegicus
418075 Gallus gallus
447596 Xenopus laevis
515605 Bos taurus
100000135 Danio rerio
100127202 Xenopus (Silurana) tropicalis
100545199 Meleagris gallopavo
100563730 Anolis carolinensis
100604575 Nomascus leucogenys
55198 Homo sapiens
216190 Mus musculus
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