You are viewing an incomplete version of our website. Please click to reload the website as full version.

Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) ELISA Kits

The protein encoded by APPL2 is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Additionally we are shipping Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 Antibodies (28) and Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 Proteins (5) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Rat APPL2 APPL2 362860  
Anti-Human APPL2 APPL2 55198 Q8NEU8
Anti-Mouse APPL2 APPL2 216190 Q8K3G9
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

More ELISA Kits for Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 Interaction Partners

Human Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) interaction partners

  1. ATM (show ATM ELISA Kits) is the central modulator of APPL (show APPL1 ELISA Kits)-mediated effects on radiosensitivity and DNA repair.

  2. It concludes that APPL2 (show APLP2 ELISA Kits)(PH) binding to BAR domain and Reptin (show RUVBL2 ELISA Kits) is mutually exclusive which regulates the nucleocytoplasmic shuttling of Reptin (show RUVBL2 ELISA Kits).

  3. C-APPL1 (show APPL1 ELISA Kits)/A-APPL2 (show APLP2 ELISA Kits) allele combination is associated with non-alcoholic fatty liver disease occurrence, with a more severe hepatic steatosis grade and with a reduced adiponectin (show ADIPOQ ELISA Kits) cytoprotective effect on liver.

  4. Data indicate that a high level of APPL2 (show APLP2 ELISA Kits) protein might enhance glioblastoma growth by maintaining low expression level of genes responsible for cell death induction.

  5. analysis of APPL1 (show APPL1 ELISA Kits) and APPL2 (show APLP2 ELISA Kits) proteins and their interaction with Rab (show HRB ELISA Kits)

  6. Genetic variation(s) in APPL1 (show APPL1 ELISA Kits)/2 may be associated with CAD (show CAD ELISA Kits) risk in T2DM in Chinese population.

  7. Data suggest that although annexin A2 (show ANXA2 ELISA Kits) is not an exclusive marker of APPL1 (show APPL1 ELISA Kits)/2 endosomes, it has an important function in membrane recruitment of APPL (show APPL1 ELISA Kits) proteins, acting in parallel to Rab5 (show RAB5A ELISA Kits).

  8. significant fluorescence resonance energy transfer between APPL (show APPL1 ELISA Kits) minimal BAR domain FRET pairs

  9. identification of a pathway directly linking the small GTPase (show RACGAP1 ELISA Kits) Rab5 (show RAB5A ELISA Kits), a key regulator of endocytosis, to signal transduction and mitogenesis via APPL1 (show APPL1 ELISA Kits) and APPL2 (show APLP2 ELISA Kits), two Rab5 (show RAB5A ELISA Kits) effectors

  10. The findings suggest a role for APPL1 (show APPL1 ELISA Kits) and APPL2 (show APLP2 ELISA Kits) protein as dynamic scaffolds that modulate RAB5 (show RAB5A ELISA Kits)-associated signaling endosomal membranes by their ability to undergo domain-mediated oligomerization, membrane targeting and phosphoinositide binding.

Mouse (Murine) Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) interaction partners

  1. Appl1 (show APPL1 ELISA Kits)/2-null mouse embryonic fibroblasts exhibited defects in HGF (show HGF ELISA Kits)-induced Akt (show AKT1 ELISA Kits) activation, migration, and invasion.

  2. Rab31 (show RAB31 ELISA Kits), with APPL2 as its effector, play a role in FcgammaR-mediated phagocytosis through PI3K/Akt (show AKT1 ELISA Kits) signaling in macrophages.

Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) Antigen Profile

Antigen Summary

The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12\;22)(q24.1\;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome.

Gene names and symbols associated with APPL2

  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (Appl2) antibody
  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (APPL2) antibody
  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (appl2) antibody
  • amyloid beta (A4) precursor-like protein 2 (APLP2) antibody
  • APPL2 antibody
  • Dip3b antibody
  • DIP13B antibody
  • MGC84621 antibody
  • RGD1563028 antibody

Protein level used designations for APPL2

DCC-interacting protein 13-beta , adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 , amyloid beta (A4) precursor-like protein 2 , DIP13 beta , adapter protein containing PH domain, PTB domain and leucine zipper motif 2 , Dip3 beta , dip13-beta

GENE ID SPECIES
362860 Rattus norvegicus
418075 Gallus gallus
447596 Xenopus laevis
515605 Bos taurus
100000135 Danio rerio
100127202 Xenopus (Silurana) tropicalis
100545199 Meleagris gallopavo
100563730 Anolis carolinensis
100604575 Nomascus leucogenys
55198 Homo sapiens
216190 Mus musculus
Did you look for something else?