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AP5Z1 was identified by genome-wide screen for genes involved in homologous recombination DNA double-strand break repair (HR-DSBR). Additionally we are shipping AP5Z1 Proteins (3) and many more products for this protein.
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Human Polyclonal AP5Z1 Primary Antibody for ICC, IF - ABIN4328703
Hirst, Edgar, Esteves, Darios, Madeo, Chang, Roda, Dürr, Anheim, Gellera, Li, Züchner, Mariotti, Stevanin, Blackstone, Kruer, Robinson: Loss of AP-5 results in accumulation of aberrant endolysosomes: defining a new type of lysosomal storage disease. in Human molecular genetics 2015
This gene was identified by genome-wide screen for genes involved in homologous recombination DNA double-strand break repair (HR-DSBR). The encoded protein was found in a complex with other proteins that have a role in HR-DSBR. Knockdown of this gene reduced homologous recombination, and mutations in this gene were found in patients with spastic paraplegia. It was concluded that this gene likely encodes a helicase (PMID:20613862).
AP-5 complex subunit zeta-1
, adapter-related protein complex 5 zeta subunit