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Adducin 2 (Beta) Proteins (ADD2)

Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. Additionally we are shipping Adducin 2 (Beta) Antibodies (47) and Adducin 2 (Beta) Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ADD2 119 P35612
ADD2 11519 Q9QYB8
ADD2 24171 Q05764
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Top Adducin 2 (Beta) Proteins at

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 39 to 44 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 39 to 44 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

ADD2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Adducin 2 (Beta) (ADD2) Interaction Partners

Human Adducin 2 (Beta) (ADD2) interaction partners

  1. ADD2 and NCX1 (show SLC8A1 Proteins) variants influence the risk and the clinical features of systemic lupus erythematosus and lupus nephritis.

  2. Taken together, these results show that beta-adducin is a pivotal lipid raft-associated protein in PSGL-1 (show SELPLG Proteins)-mediated neutrophil rolling on P-selectin (show SELP Proteins).

  3. chorein interacts with beta-adducin and beta-actin (show ACTB Proteins).

  4. phosphorylation of beta-adducin by GSK3 promotes efficient neurite outgrowth in neurons.


  6. there was significant heterogeneity between Slavic and Italian subjects in the phenotype-genotype relationships with beta-adducin

  7. Expression of the hypertensive rat or human variant of adducin into normal renal epithelial cells recreates the hypertensive phenotype with higher Na+,K+-ATPase (show ATP1A1 Proteins) activity, mu2 (show AP2M1 Proteins)-subunit hyperphosphorylation, and impaired Na+,K+-ATPase (show ATP1A1 Proteins) endocytosis.

  8. Polymorphisms in the ADD2 and ADD3 (show ADD3 Proteins) genes taken alone were not associated with blood pressure and renin (show REN Proteins) activity

  9. The very high levels of expression of ADD2 suggest that its promoter may be useful for directing erythroid-specific gene expression.

  10. beta-adducin is a downstream target of and regulated by the PTN (show PTN Proteins)/RPTPbeta (show PTPRZ1 Proteins)/zeta signaling pathway

Mouse (Murine) Adducin 2 (Beta) (ADD2) interaction partners

  1. Darpp32 (show PPP1R1B Proteins) interaction with beta-adducin may be the molecular pathway by which environmental changes may rapidly alter responsiveness of striatal neurons involved in the reward system.

  2. Calcium plays a role in regulating the expression and function of beta-adducin to sustain normal organization of the spectrin-based cytoskeleton and the differentiation properties in keratinocytes through the calmodulin/EGFR/cadherin signaling pathway.

  3. study identified novel long-distance upstream non-canonical polyadenylation-regulatory elements that enhance or silence 3'end processing of the Add2 PAS4 (show CD36 Proteins)

  4. chorein interacts with beta-adducin and beta-actin (show ACTB Proteins).

  5. mice lacking beta-Adducin fail to assemble new synapses upon enhanced plasticity and exhibit diminished long-term hippocampal memory upon environmental enrichment.

  6. Analysis of 3 new alleles reveals previously unknown consequences of red blood cell (RBC (show CACNA1C Proteins)) spectrin deficiency, resulting in markedly reduced RBC (show CACNA1C Proteins) membrane spectrin content, decreased band 3 (show SLC4A1 Proteins), and absent beta-adducin.

  7. Further analysis based on antibody staining of central and peripheral nerves revealed beta-adducin, septin 2 (show SEPT2 Proteins), and sh3p8 (show SH3GL1 Proteins) as putative paranodal proteins.

  8. beta-Adducin may play an important role in the cellular mechanisms underlying activity-dependent synaptic plasticity associated with learning and memory.

  9. Beta-adducin plays an essential role in the maintenance of erythrocyte shape and membrane stability.

  10. Targeted deletion of alpha-adducin (show ADD1 Proteins) results in absent beta- and gamma-adducin (show ADD3 Proteins), compensated hemolytic anemia, and lethal hydrocephalus in mice

Adducin 2 (Beta) (ADD2) Protein Profile

Protein Summary

Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced transcript variants have been described.

Gene names and symbols associated with Adducin 2 (Beta) Proteins (ADD2)

  • adducin 2 (beta) (ADD2)
  • adducin 2 (beta) (add2)
  • adducin 2 (beta) (Add2)
  • 2900072M03Rik protein
  • add97 protein
  • ADDB protein
  • beta-ADD protein
  • si:dkey-202n14.5 protein

Protein level used designations for Adducin 2 (Beta) Proteins (ADD2)

adducin 2 (beta) , beta-adducin , erythrocyte adducin subunit beta , beta-adducin-like , snoRNA MBII-396 , adducin beta , adducin-63

459305 Pan troglodytes
570147 Danio rerio
702939 Macaca mulatta
100125042 Xenopus (Silurana) tropicalis
100174677 Pongo abelii
100348972 Oryctolagus cuniculus
100402289 Callithrix jacchus
100483326 Ailuropoda melanoleuca
100032839 Monodelphis domestica
100050348 Equus caballus
100564223 Anolis carolinensis
100607928 Nomascus leucogenys
100624449 Sus scrofa
119 Homo sapiens
610670 Canis lupus familiaris
518896 Bos taurus
11519 Mus musculus
24171 Rattus norvegicus
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