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Adenosine Deaminase, RNA-Specific, B1 Proteins (ADARB1)

ADARB1 encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Additionally we are shipping RED1 Antibodies (33) and RED1 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ADARB1 104 P78563
ADARB1 110532 Q91ZS8
ADARB1 25367 P51400
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Top RED1 Proteins at antibodies-online.com

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$4,073.67
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HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

ADARB1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

Top referenced RED1 Proteins

  1. Human RED1 Protein expressed in Wheat germ - ABIN1305927 : Aizawa, Sawada, Hideyama, Yamashita, Katayama, Hasebe, Kimura, Yahara, Kwak: TDP-43 pathology in sporadic ALS occurs in motor neurons lacking the RNA editing enzyme ADAR2. in Acta neuropathologica 2010 (PubMed)

More Proteins for Adenosine Deaminase, RNA-Specific, B1 (ADARB1) Interaction Partners

Human Adenosine Deaminase, RNA-Specific, B1 (ADARB1) interaction partners

  1. These findings suggest that adenosine deaminase acting on RNA (show ADAR Proteins) 2 is subject to different regulations by DNA methyltransferase (show DNMT1 Proteins) and histone deacetylase (show HDAC1 Proteins) enzymes in neuronal SH-SY5Y cells.

  2. These data suggest that, like ADAR2, underlying sequences in dsRNA may influence how NF90 recognizes its target RNAs

  3. Detailed structural analysis indicates that the minor groove width of dsRNA and global shape of RNA may play an important role in the specific reading mechanism of ADAR2.

  4. A-to-I RNA editing levels catalyzed by ADAR1 (show ADAR Proteins) and ADARB1 decreased in Alzheimer's disease patients' brain tissues, mainly in the hippocampus and to a lesser degree in the temporal and frontal lobes.

  5. we conclude that this aberrant alternative splicing pattern of ADAR2 downregulates A-to-I editing in glioma

  6. ADARB1 rs9983925 and rs4819035 and HTR2C rs6318 were associated with suicide attempt risk.

  7. Therefore, the expression of ADAR1 (show ADAR Proteins) and ADAR2 was analyzed in chordoma tissues. It was found that ADAR1 (show ADAR Proteins) was significantly overexpressed, which was accompanied by enhanced pre-miR (show MLXIP Proteins)-10a and pri-miR (show MLXIP Proteins)-125a A-to-I editing

  8. ADAR2 is a key factor for maintaining edited-miRNA population and balancing the expression of several essential miRNAs involved in cancer.

  9. Data show that a large fraction of the edited genes are positively correlated ADAR (ADAR1 (show ADAR Proteins)) and ADARB1 (ADAR2).

  10. The ADAR2 alternative splicing variants may be correlated with the invasiveness of gliomas.

Mouse (Murine) Adenosine Deaminase, RNA-Specific, B1 (ADARB1) interaction partners

  1. Results show that ADAR2 is important in site-specific changes of protein coding sequences but has relatively modest effects on gene expression and splicing in the adult mouse frontal cortex.

  2. Thus, Adarb1 and Adarb2 (show ADARB2 Proteins) have nearly exclusive expression within brain tissue, while Adar (show ADAR Proteins) has more appreciable expression across multiple tissues.

  3. After fear conditioning protocol, mRNA expression of ADAR2 increased in amygdala and hippocampus, and those mice had a learning-dependent increase in the alternatively spliced inactive form of ADAR2 in the amygdala.

  4. ADAR2 is a key factor for maintaining edited-miRNA population and balancing the expression of several essential miRNAs involved in cancer.

  5. This study clearly demonstrates that ADAR2 influences miRNA abundance and targeting at several levels in the mouse brain.

  6. chronically elevated intraocular pressure in adult mice reduces expression of the ADAR2 enzyme.

  7. Analysis of editing in the filamin A (show FLNA Proteins) encoding mRNA shows very high editing levels outside the nervous system; further shows FLNA (show FLNA Proteins) editing is mainly achieved by ADAR2 but that in some cases ADAR1 (show ADAR Proteins) can efficiently compensate for ADAR2.

  8. Results suggest that ADAR2-reduction is associated with progressive deterioration of nuclear architecture, resulting in vacuolated nuclei due to a Ca2 (show CA2 Proteins)+-permeable AMPA (show GRIA3 Proteins) receptor-mediated mechanism

  9. altered RNA editing efficiency of AMPA (show GRIA3 Proteins) receptors due to down-regulation of ADAR2 has a possible role in the pathophysiology of mental disorders.

  10. Goal-oriented overeating behavior of ADAR2 transgenic mice is associated with altered feeding, reward-related mRNAs and hyperactive brain mesolimbic region.

Zebrafish Adenosine Deaminase, RNA-Specific, B1 (ADARB1) interaction partners

  1. Adar2 Edits the Q/R site of AMPA (show GRIA3 Proteins) receptor Subunit gria2alpha transcript to ensure normal development of nervous system and cranial neural crest cells

RED1 (ADARB1) Protein Profile

Protein Summary

This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rat found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an ALU cassette insert and a short or long C-terminal region.

Gene names and symbols associated with ADARB1

  • adenosine deaminase, RNA-specific, B1 (RED1 homolog rat) (ADARB1)
  • adenosine deaminase, RNA-specific, B1 (adarb1)
  • adenosine deaminase, RNA-specific, B1 (ADARB1)
  • adenosine deaminase, RNA-specific, B1 (Adarb1)
  • adenosine deaminase, RNA-specific, B1a (adarb1a)
  • 1700057H01Rik protein
  • adar2 protein
  • adarb1 protein
  • AW124433 protein
  • AW558573 protein
  • BB220382 protein
  • D10Bwg0447e protein
  • DRABA2 protein
  • DRADA2 protein
  • red1 protein

Protein level used designations for ADARB1

adenosine deaminase, RNA-specific, B1 (RED1 homolog rat) , adenosine deaminase, RNA-specific, B1 (RED1 homolog) , adenosine deaminase, RNA-specific, B1 , RNA-specific adenosine deaminase B1 , double-stranded RNA-specific editase 1-like , RED1 homolog , RNA editase , RNA editing deaminase 1 , RNA-editing deaminase 1 , RNA-editing enzyme 1 , adenosine deaminase, RNA-specific, B1 (homolog of rat RED1) , double-stranded RNA-specific editase 1 , dsRNA adenosine deaminase DRADA2 , dsRNA adenosine deaminase , RNA editing deaminase of glutamate receptors , double-stranded RNA-specific editase

GENE ID SPECIES
521761 Bos taurus
100124739 Xenopus (Silurana) tropicalis
100339367 Oryctolagus cuniculus
100483845 Ailuropoda melanoleuca
100589130 Nomascus leucogenys
495438 Xenopus laevis
374087 Gallus gallus
104 Homo sapiens
487809 Canis lupus familiaris
110532 Mus musculus
25367 Rattus norvegicus
58134 Danio rerio
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