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Adenosine Deaminase, RNA-Specific Proteins (ADAR)

ADAR encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. Additionally we are shipping ADAR Antibodies (58) and ADAR Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat ADAR ADAR 81635 P55266
ADAR 103 P55265
ADAR 56417 Q99MU3
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Top ADAR Proteins at

Showing 7 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human GST tag Adenosine Deaminase, RNA-Specific (ADAR) (AA 1-176), (partial) protein (GST tag) 50 μg Log in to see 9 to 11 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Human GST tag   50 μg Log in to see 11 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 16 to 21 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

ADAR Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
Mouse (Murine)

Top referenced ADAR Proteins

  1. Human ADAR Protein expressed in Escherichia coli (E. coli) - ABIN1046940 : Kim, Wang, Sanford, Zeng, Nishikura: Molecular cloning of cDNA for double-stranded RNA adenosine deaminase, a candidate enzyme for nuclear RNA editing. in Proceedings of the National Academy of Sciences of the United States of America 1994 (PubMed)
    Show all 2 references for ABIN1046940

More Proteins for Adenosine Deaminase, RNA-Specific (ADAR) Interaction Partners

Zebrafish Adenosine Deaminase, RNA-Specific (ADAR) interaction partners

  1. The presence of ADA (show ADA Proteins) activity in zebrafish brain may be important to regulate the adenosine/inosine levels in the CNS of this species

Cow (Bovine) Adenosine Deaminase, RNA-Specific (ADAR) interaction partners

  1. These findings suggest a role of NS4A in the interaction of BVDV with ADAR that favors virus replication.

Fruit Fly (Drosophila melanogaster) Adenosine Deaminase, RNA-Specific (ADAR) interaction partners

  1. Deficiencies in the RNA-editing gene Adar increase sleep due to synaptic dysfunction in glutamatergic neurons.

  2. The study demonstrates that neuronal excitability is linked to dADAR expression levels in individual neurons.

  3. loss of Adar increases quantal size, reduces the number of quanta of neurotransmitter released and perturbs the calcium dependence of synaptic release

  4. results demonstrate a novel role for dADAR protein in rnp-4f 5'-UTR alternative intron splicing regulation which is consistent with a previously proposed model.

  5. Data suggeset that RNA editing enzyme ADAR-mediated editing is more widespread than previously indicated and largely occurs cotranscriptionally.

  6. the solution structure of the N-terminal dsRNA binding domain (dsRBD) of dADAR

  7. Abolishing dADAR auto-regulation dramatically remodels the landscape of re-coding events in a site-specific manner.

  8. network-wide temporal and spatial regulation of ADAR activity can tune the complex system of RNA-editing sites and modulate multiple ethologically relevant behavioral modalities.

  9. Our study is the first to systematically characterize the temporal and spatial expression of full-length and truncated dADAR mRNA and protein isoforms during Drosophila embryogenesis.

  10. genetic analysis of dADAR substrates in Drosophila

Human Adenosine Deaminase, RNA-Specific (ADAR) interaction partners

  1. This study reviewed that Neurologic Phenotypes Associated with Mutations in ADAR1 in patients with Aicardi-Goutieres Syndrome.

  2. Results indicated that ADAR1 might play an important role in the occurrence, progression and prognosis of cervical squamous cancer

  3. These findings suggest that adenosine deaminase acting on RNA 1 is subject to different regulations by DNA methyltransferase (show DNMT1 Proteins) and histone deacetylase (show HDAC1 Proteins) enzymes in neuronal SH-SY5Y cells.

  4. ADAR1 p150 as the major A-to-I editor in mouse embryo fibroblasts.

  5. ADAR1, in an editing-independent manner, regulates the biogenesis of miR (show MLXIP Proteins)-222 at the transcription level and thereby ICAM1 (show ICAM1 Proteins) expression, which consequently affects melanoma immune resistance.

  6. The frame-shift mutation c.2638delG and the nonsense mutation c.2867C>A in the ADAR1 gene are associated with the dyschromatosis symmetrica hereditaria.

  7. Recent research has demonstrated that inosine in the epitranscriptome and ADAR1 protein establish innate immune tolerance for host dsRNA formed by endogenous sequences.

  8. A-to-I RNA editing levels catalyzed by ADAR1 and ADARB1 (show ADARB1 Proteins) decreased in Alzheimer's disease patients' brain tissues, mainly in the hippocampus and to a lesser degree in the temporal and frontal lobes.

  9. A three-generation family exhibiting phenotypic variability with a single germline ADAR1 mutation suggests that chilblain might aggravate the clinical phenotypes of dyschromatosis symmetrica hereditaria.

  10. The function of primary RNA editing enzyme ADAR1 in pluripotent stem cells was investigated and found that loss of ADAR1 in human iPS (show SLC27A4 Proteins) cells promotes caspase3-mediated cell death.

Mouse (Murine) Adenosine Deaminase, RNA-Specific (ADAR) interaction partners

  1. we identified a novel ADAR1-dependent protective contribution through which hepatocytes guard against aberrant cytosolic RLR (show DHX58 Proteins)-RNA-sensing pathway mediated inflammatory reaction in response to acute liver IR.

  2. Thus, Adarb1 (show ADARB1 Proteins) and Adarb2 (show ADARB2 Proteins) have nearly exclusive expression within brain tissue, while Adar has more appreciable expression across multiple tissues.

  3. After fear conditioning protocol, mRNA expression of ADAR1 increased in amygdala and hippocampus.

  4. ADAR1 is an essential molecule for maintaining adult liver homeostasis and, in turn, morphological and functional integrity.

  5. The p150 (show ABL1 Proteins) isoform of ADAR1 uniquely regulated the MDA5 (show IFIH1 Proteins) pathway.

  6. transcriptional activation of Adar1 by IFN occurs in the absence of STAT1 (show STAT1 Proteins) by a non-canonical STAT2 (show STAT2 Proteins)-dependent pathway in mouse but not human cells.

  7. A-to-I editing of endogenous dsRNA is the essential function of ADAR1, preventing the activation of the cytosolic dsRNA response by endogenous transcripts.

  8. ADAR1 mutations causing Aicardi-Goutieres syndrome affect the activity of the interferon (show IFNA Proteins)-inducible cytoplasmic isoform more severely than the nuclear isoform.

  9. Analysis of editing in the filamin A (show FLNA Proteins) encoding mRNA shows very high editing levels outside the nervous system; further shows FLNA (show FLNA Proteins) editing is mainly achieved by ADAR2 (show ADARB1 Proteins) but that in some cases ADAR1 can efficiently compensate for ADAR2 (show ADARB1 Proteins).

  10. Adenosine deaminase acting on RNA 1 limits RIG-I (show DDX58 Proteins) RNA detection and suppresses IFN production responding to viral and endogenous RNAs.

ADAR Protein Profile

Protein Summary

This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with ADAR

  • adenosine deaminase, RNA-specific (adar)
  • adenosine deaminase, RNA-specific (ADAR)
  • Adenosine deaminase acting on RNA (Adar)
  • adenosine deaminase acting on RNA (Adar)
  • adenosine deaminase acting on RNA (CpipJ_CPIJ011849)
  • adenosine deaminase, RNA-specific (Adar)
  • adar protein
  • Adar1 protein
  • adr protein
  • AGS6 protein
  • AV242451 protein
  • cg12598 protein
  • dAdar protein
  • Dmel\\CG12598 protein
  • DRADA protein
  • DSH protein
  • DSRAD protein
  • dsRAD-1 protein
  • EG:BACN35H14.1 protein
  • G1P1 protein
  • hypnos-2 protein
  • IFI-4 protein
  • IFI4 protein
  • K88DSRBP protein
  • mZaADAR protein
  • NV18763 protein
  • P136 protein
  • red1 protein
  • wu:fc22a02 protein

Protein level used designations for ADAR

double-stranded RNA-specific adenosine deaminase , dsRNA adenosine deaminase , adenosine deaminase, RNA-specific , RNA-specific adenosine deaminase , Adar-PA , Adar-PB , Adar-PC , Adar-PD , Adar-PE , Adar-PF , Adar-PH , Adar-PI , Adar-PJ , Adar-PK , Adar-PL , Adar-PM , CG12598-PA , CG12598-PB , CG12598-PC , CG12598-PD , CG12598-PE , CG12598-PF , CG12598-PH , CG12598-PI , CG12598-PJ , CG12598-PK , CG12598-PL , CG12598-PM , adenosine deaminase acting on RNA , adenosine deaminases acting on RNA , hypoxia, anoxia, sensitive 2 , DRADA , 136 kDa double-stranded RNA-binding protein , adenosine deaminase acting on RNA 1-A , interferon-induced protein 4 , interferon-inducible protein 4 , RNA adenosine deaminase 1 , RNA-specific adenosine deaminase p110 form , RNA-specific adenosine deaminase p150 form

58119 Danio rerio
397992 Xenopus laevis
505134 Bos taurus
769675 Gallus gallus
31130 Drosophila melanogaster
408529 Apis mellifera
6044765 Culex quinquefasciatus
100114127 Nasonia vitripennis
81635 Rattus norvegicus
103 Homo sapiens
56417 Mus musculus
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