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ADK an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Additionally we are shipping ADK Antibodies (113) and ADK Kits (12) and many more products for this protein.
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Human ADK Protein expressed in Escherichia coli (E. coli) - ABIN667133
Chakraborty, Das, Datta, Sen, Bhattacharyya, Mandal, Datta: A single-domain cyclophilin from Leishmania donovani reactivates soluble aggregates of adenosine kinase by isomerase-independent chaperone function. in The Journal of biological chemistry 2002
Show all 2 references for ABIN667133
Human ADK Protein expressed in Baculovirus infected Insect Cells - ABIN2005495
Kuettel, Greenwald, Kostrewa, Ahmed, Scapozza, Perozzo: Crystal structures of T. b. rhodesiense adenosine kinase complexed with inhibitor and activator: implications for catalysis and hyperactivation. in PLoS neglected tropical diseases 2011
Show all 2 references for ABIN2005495
Adenosine kinase contributes to cytokinin homeostasis
Increased cytokinin-responsive promoter activity in Arabidopsis plant tissue may therefore be a consequence of an ADK/AL2/C2 interaction.
ADA (show ADA Proteins) and ADK are involved in glioma progression; increased ADA (show ADA Proteins) and ADK levels in peritumoral tissues may be associated with epilepsy in glioma patients.
The results of this study suggest that upregulation of ADK is a common pathologic component of FCDIIB.
These results suggest that upregulation of ADK is a common pathologic hallmark of Rasmussen encephalitis and that ADK might be a target in the treatment of epilepsy associated with Rasmussen encephalitis.
Data show that we a significantly higher expression of ADK in the peritumoral infiltrated tissue of patients with epilepsy than in patients without epilepsy.
The results of this study suggested that dysregulation of ADK in astrocytes is a common pathologic hallmark of temporal lobe epilepsy.
The cytoplasmic isoform of adenosine kinase is sufficient to alter sleep physiology. ADK might orchestrate neurotransmitter pathways involved in the generation of electroencephlogram oscillations and regulation of sleep.
The catalytic properties, gene expression and protein levels of certain proteins involved in mitochondrial ATP synthesis, such as F1F0-ATPase, ANT and AK, in human skin fibroblasts with trisomic karyotype, compared them with euploid fibroblasts.
Equilibrative nucleoside transporters (hENT1, hENT2) together with adenosine kinase and 5'-nucleotidase (show NT5E Proteins) play a crucial role in the regulation of CFTR (show CFTR Proteins) through an adenosine-dependent pathway in human airway epithelia.
role for HIF-1alpha (show HIF1A Proteins) in transcriptional repression of AK in hypoxia
adenosine kinase gene expression was significantly higher in cancer than in normal-appearing tissue, in line with our previous measurements of adenosine kinase enzyme activities in colorectal tumor samples
The findings of this study implicated a glial-neuronal circuit, mediated by Ado (show ADO Proteins), neuronal AdoRA1, and glial AdK that can modulate sleep homeostasis in a manner influenced by glial metabolic state.
We conclude that ADK provides important upstream regulation of adenosine-based homeostatic function of the brain
Adenosine kinase inhibition selectively promotes rodent and porcine islet beta-cell replication
Knockdown of Adk can protect the brain from the effects of a stroke.
a complete absence of ADK led to abnormalities in hepatic adenosine metabolism and to the development of acute, severe neonatal hepatic steatosis.
adenosine kinase inhibition promotes survival of fetal adenosine deaminase (show ADA Proteins)-deficient thymocytes by blocking dATP accumulation
Overexpression of adenosine kinase in discrete parts of the epileptic hippocampus may contribute to the development and progression of seizure activity.
Data report the cloning of two isoforms of adenosine kinase from a mouse brain cDNA library, and the role of these isoenzymes as sustrates for phosphorylation were examined.
transient downregulation of hippocampal ADK after stroke might be a protective mechanism during maturation hippocampal cell loss.
The results of this study confirmed that ADK overexpression could lead to functional concomitant alterations in dopaminergic and glutamatergic functions.
This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene.
, adenosine kinase (short isoform)-like protein
, Adenosine kinase
, adenosine kinase-like
, adenosine 5'-phosphotransferase
, Adenosine 5'-phosphotransferase