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S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. Additionally we are shipping AHCY Proteins (90) and AHCY Kits (13) and many more products for this protein.
Showing 10 out of 95 products:
Human Polyclonal AHCY Primary Antibody for EIA, IHC (p) - ABIN950286
Giusti, Saracini, Bolli, Magi, Martinelli, Peyvandi, Rasura, Volpe, Lotta, Rubattu, Mannucci, Abbate: Early-onset ischaemic stroke: analysis of 58 polymorphisms in 17 genes involved in methionine metabolism. in Thrombosis and haemostasis 2010
Show all 4 references for ABIN950286
Human Polyclonal AHCY Primary Antibody for EIA, IHC (p) - ABIN357876
Arredondo-Vega, Charlton, Edwards, Hopkinson, Whitehouse: Isozyme and DNA analysis of human S-adenosyl-L-homocysteine hydrolase (AHCY). in Annals of human genetics 1990
Show all 3 references for ABIN357876
Human Polyclonal AHCY Primary Antibody for EIA, IHC (p) - ABIN357877
Yideng, Jianzhong, Ying, Juan, Jinge, Shenglan, Xiaoqun, Shuren: Homocysteine-mediated expression of SAHH, DNMTs, MBD2, and DNA hypomethylation potential pathogenic mechanism in VSMCs. in DNA and cell biology 2007
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Human Monoclonal AHCY Primary Antibody for ELISA, WB - ABIN513196
Fernandez-Sanchez, Gonatopoulos-Pournatzis, Preston, Lawlor, Cowling: S-adenosyl homocysteine hydrolase is required for Myc-induced mRNA cap methylation, protein synthesis, and cell proliferation. in Molecular and cellular biology 2009
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Cow (Bovine) Polyclonal AHCY Primary Antibody for WB - ABIN2784617
Li, Cai, Fang, Borchardt, Kuczera, Middaugh, Schowen: Comparative kinetics of cofactor association and dissociation for the human and trypanosomal S-adenosylhomocysteine hydrolases. 2. The role of helix 18 stability. in Biochemistry 2008
Mouse (Murine) Polyclonal AHCY Primary Antibody for FACS, IHC (p) - ABIN655151
Jugessur, Shi, Gjessing, Lie, Wilcox, Weinberg, Christensen, Boyles, Daack-Hirsch, Nguyen, Christiansen, Lidral, Murray: Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. in PLoS ONE 2010
H19 (show NCKAP1 Antibodies) knockdown activates SAHH, leading to increased DNMT3B (show DNMT3B Antibodies)-mediated methylation of an lncRNA-encoding gene Nctc1 within the Igf2-H19 (show NCKAP1 Antibodies)-Nctc1 locus.
S-adenosylhomocysteine hydrolase is regulated by lysine acetylation
SAHH can promote apoptosis, inhibit migration and adhesion of ESCC cells suggesting that it may be involved in carcinogenesis of the esophagus.
A fluorescence-based assay for the measurement of S-adenosylhomocysteine hydrolase activity in biological samples.
Maintenance of ionizable active-site residues in catalytically suitable protonation states in closed forms of placental AHCY may be assisted by a water chain, stabilized by Asp182, that can import and export protons from and to the environment.
SAHH, which is diffuse in the cytoplasm of nonmotile Dictyostelium amoebae and human neutrophils, concentrates with F-actin in pseudopods at the front of motile, chemotaxing cells
In the case of Hs-SAHH, the slow-binding phase terminates in micromolar affinity, but over a period of hours, the dissociation rate constant decreases until the final equilibrium affinity is in the nanomolar range.
We found clinically relevant levels of Hcy (0-500 microM) induced elevation of SAH (show ACSM3 Antibodies), declination of SAM (show TTN Antibodies) and SAM (show TTN Antibodies)/SAH (show ACSM3 Antibodies) ratio and reduced expression of SAHH and MBD2 (show DPEP2 Antibodies), but increased activity of DNMT3a (show DNMT3A Antibodies) and DNMT3b (show DNMT3B Antibodies) affecting DNA methylation (show HELLS Antibodies)
consider changes in charge and the sterical incompatibility in mutant p.A89V protein as main reason for enzyme malfunction with AdoHcyase deficiency as consequence
SAHH from Homo sapiens (Hs-SAHH) and from the parasite Trypanosoma cruzi (Tc-SAHH) are very similar in structure and catalytic properties but differ in the kinetics and thermodynamics of association and dissociation of the cofactor NAD (+)
Ahcy was identified from coupling of methylation with gene expression data, shed light on the underlying mechanisms of cytosine demethylation under methyl-deficient conditions.
report the crystallization of mouse SAHH in the presence of the reaction product adenosine. The crystals diffracted to at least 1.55 A degrees resolution and are suitable for X-ray structure analysis at high resolution.
report that Myc (show MYC Antibodies) promotes upregulation of S-adenosyl homocysteine hydrolase.
AHCYL1 (show AHCYL1 Antibodies) has a different function from AHCY and plays an important role in embryogenesis by modulating inositol 1,4,5-trisphosphate receptor function for the intracellular calcium release
Hepatic steatosis and liver degeneration are prominent features of the ducttrip (dtp) mutant phenotype. Positional cloning identified a causative mutation in the gene encoding S-adenosylhomocysteine hydrolase (Ahcy).
S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, S-adenosyl-L-homocysteine hydrolase
, S-adenosyl-L-homocysteine hydrolase B
, adenosylhomocysteinase B
, adoHcyase B
, liver copper-binding protein