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Adenosylhomocysteinase Proteins (AHCY)

S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. Additionally we are shipping AHCY Antibodies (95) and AHCY Kits (13) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Human AHCY AHCY 191 P23526
Rat AHCY AHCY 29443 P10760
Mouse AHCY AHCY 269378 P50247
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Top AHCY Proteins at antibodies-online.com

Showing 10 out of 90 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$286.00
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 2 to 3 Days
$441.00
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Yeast His tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Streptomyces fradiae His tag   1 mg Log in to see 56 to 66 Days
$2,236.67
Details
Yeast Archaeoglobus fulgidus His tag   1 mg Log in to see 56 to 66 Days
$3,122.17
Details
Yeast REACT_Aquifex aeolicus His tag   1 mg Log in to see 56 to 66 Days
$3,162.50
Details

AHCY Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Rat (Rattus)

Mouse (Murine)

Top referenced AHCY Proteins

  1. Human AHCY Protein expressed in Escherichia coli (E. coli) - ABIN667029 : Gellekink, den Heijer, Kluijtmans, Blom: Effect of genetic variation in the human S-adenosylhomocysteine hydrolase gene on total homocysteine concentrations and risk of recurrent venous thrombosis. in European journal of human genetics : EJHG 2004 (PubMed)
    Show all 2 references for ABIN667029

More Proteins for Adenosylhomocysteinase (AHCY) Interaction Partners

Human Adenosylhomocysteinase (AHCY) interaction partners

  1. SAH (show ACSM3 Proteins) hydrolase deficiency can remain asymptomatic in childhood, and the disorder can be associated with early onset hepatocellular carcinoma.

  2. H19 (show NCKAP1 Proteins) knockdown activates SAHH, leading to increased DNMT3B (show DNMT3B Proteins)-mediated methylation of an lncRNA-encoding gene Nctc1 within the Igf2-H19 (show NCKAP1 Proteins)-Nctc1 locus.

  3. S-adenosylhomocysteine hydrolase is regulated by lysine acetylation

  4. SAHH can promote apoptosis, inhibit migration and adhesion of ESCC cells suggesting that it may be involved in carcinogenesis of the esophagus.

  5. A fluorescence-based assay for the measurement of S-adenosylhomocysteine hydrolase activity in biological samples.

  6. Maintenance of ionizable active-site residues in catalytically suitable protonation states in closed forms of placental AHCY may be assisted by a water chain, stabilized by Asp182, that can import and export protons from and to the environment.

  7. SAHH, which is diffuse in the cytoplasm of nonmotile Dictyostelium amoebae and human neutrophils, concentrates with F-actin in pseudopods at the front of motile, chemotaxing cells

  8. In the case of Hs-SAHH, the slow-binding phase terminates in micromolar affinity, but over a period of hours, the dissociation rate constant decreases until the final equilibrium affinity is in the nanomolar range.

  9. We found clinically relevant levels of Hcy (0-500 microM) induced elevation of SAH (show ACSM3 Proteins), declination of SAM (show TTN Proteins) and SAM (show TTN Proteins)/SAH (show ACSM3 Proteins) ratio and reduced expression of SAHH and MBD2 (show DPEP2 Proteins), but increased activity of DNMT3a (show DNMT3A Proteins) and DNMT3b (show DNMT3B Proteins) affecting DNA methylation (show HELLS Proteins)

  10. consider changes in charge and the sterical incompatibility in mutant p.A89V protein as main reason for enzyme malfunction with AdoHcyase deficiency as consequence

Mouse (Murine) Adenosylhomocysteinase (AHCY) interaction partners

  1. H19 (show NCKAP1 Proteins) knockdown activates SAHH, leading to increased DNMT3B (show DNMT3B Proteins)-mediated methylation of an lncRNA-encoding gene Nctc1 within the Igf2-H19 (show NCKAP1 Proteins)-Nctc1 locus.

  2. Ahcy was identified from coupling of methylation with gene expression data, shed light on the underlying mechanisms of cytosine demethylation under methyl-deficient conditions.

  3. report the crystallization of mouse SAHH in the presence of the reaction product adenosine. The crystals diffracted to at least 1.55 A degrees resolution and are suitable for X-ray structure analysis at high resolution.

  4. report that Myc (show MYC Proteins) promotes upregulation of S-adenosyl homocysteine hydrolase.

Zebrafish Adenosylhomocysteinase (AHCY) interaction partners

  1. AHCYL1 (show AHCYL1 Proteins) has a different function from AHCY and plays an important role in embryogenesis by modulating inositol 1,4,5-trisphosphate receptor function for the intracellular calcium release

  2. Hepatic steatosis and liver degeneration are prominent features of the ducttrip (dtp) mutant phenotype. Positional cloning identified a causative mutation in the gene encoding S-adenosylhomocysteine hydrolase (Ahcy).

AHCY Protein Profile

Protein Summary

S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Adenosylhomocysteinase Proteins (AHCY)

  • adenosylhomocysteinase (AHCY)
  • adenosylhomocysteinase (ahcy)
  • adenosylhomocysteinase (ahcY)
  • Adenosylhomocysteinase (ahcY)
  • adenosylhomocysteinase (Mmah_0523)
  • adenosylhomocysteinase (Srot_2217)
  • adenosylhomocysteinase (Ndas_3755)
  • adenosylhomocysteinase (Deba_0936)
  • adenosylhomocysteinase (Palpr_2392)
  • adenosylhomocysteinase (Calni_0569)
  • adenosylhomocysteinase (LOC100282150)
  • adenosylhomocysteinase (Intca_2510)
  • adenosylhomocysteinase (Marky_0392)
  • adenosylhomocysteinase (Desac_1394)
  • S-adenosylhomocysteine hydrolase (Tc00.1047053511229.50)
  • S-adenosylhomocysteine hydrolase (Tc00.1047053511589.200)
  • S-adenosylhomocysteine hydrolase (Tb11.01.1350)
  • S-adenosylhomocysteine hydrolase (LmjF36.3910)
  • S-adenosylhomocysteine hydrolase (MCYG_06244)
  • S-adenosylhomocysteine hydrolase (Ahcy)
  • adenosylhomocysteinase (Ahcy)
  • adenosylhomocysteinase (ahcy-b)
  • S-adenosylhomocysteine hydrolase (ahcy)
  • AA987153 protein
  • adoHcyase protein
  • ahcy protein
  • AL024110 protein
  • cb1079 protein
  • CuBP protein
  • D150 protein
  • hm:zeh1173 protein
  • hm:zeh1364 protein
  • PSPTO5068 protein
  • SAHH protein
  • wu:fj67b02 protein

Protein level used designations for Adenosylhomocysteinase Proteins (AHCY)

S-adenosylhomocysteine hydrolase , adenosylhomocysteinase , Adenosylhomocysteinase , adenosylhomocysteinase-like , S-adenosyl-L-homocysteine hydrolase , adoHcyase , S-adenosyl-L-homocysteine hydrolase B , adenosylhomocysteinase B , adoHcyase B , liver copper-binding protein , dtp

GENE ID SPECIES
458190 Pan troglodytes
733486 Xenopus (Silurana) tropicalis
1186753 Pseudomonas syringae pv. tomato str. DC3000
8681312 Methanocella paludicola SANAE
8790426 Azospirillum sp. B510
8994525 Salinibacter ruber M8
9483094 Candidatus Nitrospira defluvii
100440671 Pongo abelii
8982664 Methanohalophilus mahii DSM 5219
9180283 Segniliparus rotundus DSM 44985
9247624 Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111
9493389 Desulfarculus baarsii DSM 2075
10000059 Paludibacter propionicigenes WB4
10008577 Calditerrivibrio nitroreducens DSM 19672
100282150 Zea mays
10085337 Intrasporangium calvum DSM 43043
10433277 Marinithermus hydrothermalis DSM 14884
10436597 Desulfobacca acetoxidans DSM 11109
3539733 Trypanosoma cruzi strain CL Brener
3547847 Trypanosoma cruzi strain CL Brener
3664299 Trypanosoma brucei brucei strain 927/4 GUTat10.1
5655685 Leishmania major strain Friedlin
9227886 Arthroderma otae CBS 113480
100113808 Nasonia vitripennis
191 Homo sapiens
29443 Rattus norvegicus
503682 Xenopus laevis
477198 Canis lupus familiaris
497050 Sus scrofa
508158 Bos taurus
269378 Mus musculus
387530 Danio rerio
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