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The protein encoded by AHCYL1 interacts with inositol 1,4,5-trisphosphate receptor, type 1 and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Additionally we are shipping AHCYL1 Proteins (5) and AHCYL1 Kits (3) and many more products for this protein.
Showing 10 out of 38 products:
Human Polyclonal AHCYL1 Primary Antibody for ELISA, WB - ABIN564694
Yamaguchi, Ishikawa: IRBIT reduces the apparent affinity for intracellular Mg²? in inhibition of the electrogenic Na?-HCO?? cotransporter NBCe1-B. in Biochemical and biophysical research communications 2012
Human Monoclonal AHCYL1 Primary Antibody for IHC (p), ELISA - ABIN564695
Scicchitano, Dalmas, Boyce, Thomas, Frazier: Protein extraction of formalin-fixed, paraffin-embedded tissue enables robust proteomic profiles by mass spectrometry. in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2009
IRBIT forms signaling complexes with PIPKIalpha and NBCe1 (show SLC4A4 Antibodies)-B, whose activity is regulated by PI(4,5)P2.
Formation of the Ribonucleotide reductase-IRBIT complex is regulated through phosphorylation of IRBIT, and ablation of IRBIT expression in HeLa cells causes imbalanced dNTP pools and altered cell cycle progression.
IRBIT is a master regulator of ion channels and ion transporters. (Review)
IRBIT plays an important role in intracellular pH regulation, mediated by NHE3 (show SLC9A3 Antibodies), and further regulated by SPAK (show STK39 Antibodies).
relationships between the WNK/SPAK (show STK39 Antibodies) and IRBIT/PP1 (show PPA1 Antibodies) sites in the regulation of Na+-HCO3- cotransporters
conclude that AHCYL1 expression is associated with ovarian carcinogenesis as an oncogene (show RAB1A Antibodies) in chickens, whereas it plays the role of tumor suppressor in human EOC, suggesting a paradoxical function of AHCYL1 in ovarian carcinogenesis
A NBCe1 (show SLC4A4 Antibodies)-B construct that lacks amino acid residues 2-16 of the amino-terminus is fully autoinhibited, but cannot be stimulated by IRBIT, indicating that autoinhibitory and IRBIT-binding determinants within the cytosolic amino-terminus are not identical.
Both IRBIT (inositol 1,4,5-trisphosphate receptor-binding protein) and WNK [with no lysine (K)] kinase have been implicated as additional HCO(3)(-) secretory controllers.
IRBIT opposes the effects of WNKs and SPAK (show STK39 Antibodies) by recruiting PP1 (show PPA1 Antibodies) to the complex to dephosphorylate CFTR (show CFTR Antibodies) and NBCe1 (show SLC4A4 Antibodies)-B, restoring their cell surface expression, in addition to stimulating their activities
IRBIT is critically involved in mediating activation of NHE3 (show SLC9A3 Antibodies) by ANG II (show AGT Antibodies) via a Ca(2 (show CA2 Antibodies)+)/calmodulin (show CALM1 Antibodies)-dependent protein kinases II-dependent pathway.
AHCYL1 has a different function from AHCY (show AHCY Antibodies) and plays an important role in embryogenesis by modulating inositol 1,4,5-trisphosphate receptor function for the intracellular calcium release
NHERF1 (show SLC9A3R2 Antibodies) mediates ANG II (show AGT Antibodies)-induced activation of renal NHE3 (show SLC9A3 Antibodies), which requires coordination between IRBIT and the NHERF1 (show SLC9A3R2 Antibodies) PDZ1 domain in binding and transporting NHE3 (show SLC9A3 Antibodies)
IRBIT suppresses CaMKIIalpha (show CAMK2 Antibodies) activity and contributes to catecholamine homeostasis through TH phosphorylation.
Irbit was sequestered by InsP3 receptors (IP3Rs) in the endoplasmic reticulum
IRBIT opposes the effects of WNKs and SPAK (show STK39 Antibodies) by recruiting PP1 (show PPP1CC Antibodies) to the complex to dephosphorylate CFTR (show CFTR Antibodies) and NBCe1 (show SLC4A4 Antibodies)-B, restoring their cell surface expression, in addition to stimulating their activities
IRBIT can directly interact with the IP3R (show ITPR1 Antibodies), and that both the suppressor domain and the IP3-binding core of the IP3R (show ITPR1 Antibodies) are essential for a strong interaction.
phosphorylation of Ser71 and Ser74 were sufficient to enable inhibition of IP3 binding to the IP3R (show ITPR1 Antibodies) by IRBIT
Data show that pNBC1 activation requires the IRBIT PEST domain, while CFTR (show CFTR Antibodies) activation requires multiple domains, and suggest that IRBIT is a key coordinator of epithelial fluid and HCO3- secretion.
Results sugest that IRBIT modulates the polyadenylation state of specific mRNAs, both by controlling the cytoplasmic/nuclear partitioning of Fip1 (show RRAGA Antibodies) and by inhibiting PAP (show ASAP1 Antibodies) activity, in response to a stimulus that alters its phosphorylation state.
The protein encoded by this gene interacts with inositol 1,4,5-trisphosphate receptor, type 1 and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Several transcript variants encoding two different isoforms have been found for this gene.
, putative adenosylhomocysteinase 2-like
, S-adenosylhomocysteine hydrolase-like 1
, putative adenosylhomocysteinase 2
, DC-expressed AHCY-like molecule
, S-adenosyl homocysteine hydrolase homolog
, S-adenosyl-L-homocysteine hydrolase 2
, S-adenosylhomocysteine hydrolase-like protein 1
, adoHcyase 2
, dendritic cell expressed AHCY-like protein
, inositol 1,4,5-trisphosphate receptor-binding protein
, IP3R binding protein released with inositol 1,4,5-trisphosphate
, IP3R-binding protein released with inositol 1,4,5-trisphosphate
, S-adenosylhomocysteine hydrolase, related sequence 3