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Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP.
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ADCY8 is required for the physiological activation of glucose-induced signalling pathways in beta cells, for glucose tolerance and for hypothalamic adaptation to a high-fat diet via regulation of islet insulin (show INS Antibodies) secretion.
ADCY8 is integral for long-term potentiation and synaptic plasticity and is implicated in fear-related learning and memory.
Polymorphisms ADCY8 are associated with an alcohol-dependent phenotype in females, which is distinguished by comorbid signs of depression.
The adenylate cyclase 8 plays a major role in cAMP production.
Orai1 (show ORAI1 Antibodies) and AC8 binding mediates dynamic interplay between Ca2 (show CA2 Antibodies)+ and cAMP signaling
cAMP-mediated pathways are modelled by glucose, and downregulation of the calcium-sensitive ADCY8 plays a central role herein, including signalling via the GLP1R (show GLP1R Antibodies).
Ca2 (show CA2 Antibodies)+ entry increase was accompanied by red cell aggregation rise, while adenylyl cyclase-cAMP system stimulation led to red cell deformability increase and its aggregation lowered.
Data reveal that an association of the Ca(2 (show CA2 Antibodies)+)-stimulable AC8 with AKAP79 (show AKAP5 Antibodies)/150 that limits the sensitivity of AC8 to intracellular Ca(2 (show CA2 Antibodies)+) events.
The data of this study suggested that Adcy8 might encode a translational behavioral endophenotype of bipolar disorder.
Cyclic AMP (show APRT Antibodies) compartmentation due to increased cAMP-phosphodiesterase activity in transgenic mice expressing human adenylyl cyclase type 8.
Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase
ATP pyrophosphate-lyase 8
, adenylate cyclase type 8
, adenylate cyclase type VIII
, adenylyl cyclase 8
, adenylyl cyclase-8, brain
, ca(2+)/calmodulin-activated adenylyl cyclase