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Plays a role in cell adhesion and cell migration (By similarity).. Additionally we are shipping AJAP1 Antibodies (18) and many more products for this protein.
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Reduced Expression of Adherens Junctions Associated Protein 1 is associated with Recurrence of Hepatocellular Carcinoma After Curative Hepatectomy.
These findings indicate that downregulated AJAP1 transcription may serve as a novel tumor biomarker to predict recurrence of ESCC after esophagectomy.
Article summarizes and discusses current knowledge that may identify AJAP1 as a tumor suppressor in gliomas. [Review]
Results show that AJAP1 is dysregulated at an early stage of gliomagenesis and may suppress glioma cell invasion and proliferation, which suggests that AJAP1 may be a potential diagnostic and prognostic marker for gliomas
AJAP1 suppressed the expression of MAGEA2 and inhibited the transcriptional activity of MAGEA2 in glioma cells.
We also identified a significant genetic association between caries of the mid- dentition tooth surfaces and AJAP1 (p value = 2e-8), a gene possibly involved in tooth development.
This work shows the significant loss of expression of AJAP1 in glioblastoma and provides evidence of its role in the highly migratory characteristic of these tumors.
Both genetic (gene deletion) and epigenetic alterations (promoter methylation) are likely mechanisms that inactivate the putative tumor suppressor AJAP1 in gliomas, which contributes to poor prognosis.
Data show that overexpression of shrew-1 leads to preformation of an E-cadherin (show CDH1 Proteins)/EGF receptor (show EGFR Proteins)/HER2 (show ERBB2 Proteins)/src-kinase (show CSK Proteins)/shrew-1 signaling complex and accelerated E-cadherin (show CDH1 Proteins) internalization.
While a mutation was not detected in the coding region of the SHREW1 gene in oligodendrogliomas, SHREW1 expression restoration resulted in suppression of cell adhesion and migration, thus, SHREW1 inactivation may lead to oligodendroglial tumorigenesis.
Plays a role in cell adhesion and cell migration (By similarity).
adherens junction-associated protein 1
, likely ortholog of H. sapiens transmembrane protein SHREW1
, adherens junction associated protein 1
, membrane protein shrew-1
, transmembrane protein SHREW1