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ADRA1A encodes one of several multipass transmembrane proteins that function as G protein-coupled receptors.
Male mouse and marmoset proximal urethral smooth muscle shows strong alpha1A- adrenoceptor-induced contractions and abundant alpha1A-adrenoceptor expression, whereas alpha1A-adrenoceptor-mediated mechanisms are much less important in females.
alpha(1)-AR activation is anti-apoptotic and protective during cardiac ischemia due to glucose deprivation and not hypoxia by enhancing glucose uptake into the heart via PKCdelta (show PKCd ELISA Kits)-mediated GLUT (show SLC1A3 ELISA Kits) translocation that may be specific to the alpha(1A)-AR subtype.
Data identify a novel, "inside-out" nuclear a1A-subtype/PKCd/cTnI-signaling pathway that regulates contractile function in adult cardiac myocytes.
Male contraception via simultaneous knockout of alpha1A (show CACNA1A ELISA Kits)-adrenoceptors and P2X1 (show P2RX1 ELISA Kits)-purinoceptors in mice.
We have provided the first evidence for specific heteromerization between the alpha(1A)-adrenoceptor (alpha(1A)AR) and CXC chemokine receptor (show CXCR4 ELISA Kits) 2 (CXCR2 (show CXCR2 ELISA Kits)) in live cells.
sustained activation of IL-1 (show IL1A ELISA Kits) signaling....affects the expression of the ARalpha(1A) subtype..and that modification of adrenergic signaling by the IL-1 (show IL1A ELISA Kits) system may ultimately cause significant psychiatric abnormalities such as depression
Findings uncover a vascular signaling pathway linking alpha(1)-adrenergic receptors and pressure to WNK1 (show WNK1 ELISA Kits), SPAK (show STK39 ELISA Kits), and NKCC1 (show SLC12A2 ELISA Kits) and may, thus, significantly broaden the comprehension of the regulatory mechanisms of vascular tone in arterial hypertension.
Activation of the adrenergic receptor alpha 1a subtype enhances learning and memory and has antidepressant and antianxiety effects.
result is consistent with coimmunoprecipitation experiments from thoracodorsal resistance arteries, which suggested an association between Pannexin1 (show PANX1 ELISA Kits) and alpha1D-adrenergic receptor
the alpha1A-adrenoceptor plays the major role in noradrenaline-induced contraction in ureters
This gene encodes one of several multipass transmembrane proteins that function as G protein-coupled receptors. The encoded protein binds to epinephrine and norepinephrine to mediate signaling in cells of the cardiac, nervous, and other organ systems. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
alpha-1A adrenergic receptor
, alpha-1A adrenoceptor
, alpha-1A adrenoreceptor
, alpha-1C adrenergic receptor
, adrenergic alpha 1c receptor
, adrenergic receptor alpha 1c subtype
, adrenergic receptor, alpha 1a
, adrenergic receptor, alpha 1c
, adrenergic, alpha-1A-, receptor
, alpha 1A-adrenoceptor
, alpha 1A-adrenoreceptor
, alpha 1C-adrenergic receptor