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Agouti Signaling Protein Proteins (ASIP)

In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Additionally we are shipping Agouti Signaling Protein Antibodies (19) and Agouti Signaling Protein Kits (11) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ASIP 434 P42127
Rat ASIP ASIP 24152 Q99JA2
ASIP 50518 Q03288
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Top Agouti Signaling Protein Proteins at antibodies-online.com

Showing 10 out of 27 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$2,203.67
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Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,203.67
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Yeast Primates His tag   1 mg Log in to see 56 to 66 Days
$2,205.50
Details
Yeast Macaca sylvanus His tag   1 mg Log in to see 56 to 66 Days
$2,205.50
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Yeast Callithrix jacchus His tag   1 mg Log in to see 56 to 66 Days
$2,205.50
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Yeast Primate His tag   1 mg Log in to see 56 to 66 Days
$2,205.50
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Yeast Primate His tag   1 mg Log in to see 56 to 66 Days
$2,205.50
Details

ASIP Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Rat (Rattus)

Mouse (Murine)

More Proteins for Agouti Signaling Protein (ASIP) Interaction Partners

Cow (Bovine) Agouti Signaling Protein (ASIP) interaction partners

  1. Our results provide evidence for a widespread expression of ASIP in bovine tissues at mRNA and, for the first time, at protein level.

  2. Possible consequences of Abr (agouti gene mutated by insertion of LINE element)for meat and milk production in cattle.

Human Agouti Signaling Protein (ASIP) interaction partners

  1. Polymorphisms of ASIP were found to be associated with skin, hair, and eye color in a phenotypically diverse Brazilian population. More research is needed to determine its usefulness in forensic science.

  2. ASIP gene mutation is involved in the development of facial pigmented lesions.

  3. Data show that ASIP TG/TG (show TG Proteins) diplotype, which is known to be associated with melanoma risk, was linked to a 5-fold increase in hazard of death from melanoma.

  4. An increased risk of melanoma (odds ratio [OR] 1.27, 95% confidence interval [95% CI] 1.03-1.57) in carriers of the rs4911414 variant, located 120 kb upstream of ASIP.

  5. By using a population-based material of high-risk melanoma cases, we demonstrate a significant effect of both MC1R (show MSHR Proteins) red hair color (RHC) variants and an ASIP haplotype, but could not replicate an association with postulated risk SNPs of TYR (show TYR Proteins) and TYRP1 (show TYRP1 Proteins).

  6. Findings suggest that ASIP locus is associated with a number of non-melanoma skin cancers.

  7. Further analysis of binding and functional data suggests that the ASIP C-terminal loop (a six-amino-acid segment closed by the final disulfide bond) is essential for high-affinity MC1R binding and inverse agonism.

  8. polymorphism in the agouti signaling protein gene is associated with human pigmentation

  9. results show that men and women of similar age and BMI present similar agouti signal protein mRNA levels in omental and subcutaneous abdominal adipocytes but a sexual dimorphism exists in the relationship between its expression and BMI

  10. Results identify five genes that are down-regulated by agouti signalling protein (ASIP), indicating a likely role for ASIP in human melanogenesis.

Pig (Porcine) Agouti Signaling Protein (ASIP) interaction partners

  1. Mutational analysis of the ASIP loci in relation to coat color.

Horse (Equine) Agouti Signaling Protein (ASIP) interaction partners

  1. there was a correlation between the recessive ASIP allele and a more independent temperament

Mouse (Murine) Agouti Signaling Protein (ASIP) interaction partners

  1. Par-3 plays an important role in the modulation of intestinal barrier function by regulating delivery of occludin as well as suppression of MLC phosphorylation.

  2. HTT (show HTT Proteins) is required for the apical localization of PAR3 (show F2RL2 Proteins)-aPKC during epithelial morphogenesis in virgin, pregnant, and lactating mice.

  3. Methylation analysis reveals that although most lines display normal methylation at IAP (show ALPI Proteins) elements in general, the Avy IAP (show ALPI Proteins) element is essentially unmethylated.

  4. Authors identify the cell polarity protein Par3, a negative regulator of neuronal differentiation, as a Smek1 (show SMEK1 Proteins) substrate and demonstrate that Smek1 (show SMEK1 Proteins) suppresses its activity.

  5. Par3 (show F2RL2 Proteins) (and protein kinase C zeta (show PRKCZ Proteins)) are activated in neurons when binding to N2-proteoglygan.

  6. Suggest that loss of Par3 (show F2RL2 Proteins) promotes metastatic behaviour of ErbB2 (show ERBB2 Proteins)-induced breast tumour epithelial cells by decreasing cell-cell cohesion.

  7. Par3 (show F2RL2 Proteins) is identified as a regulator of signaling pathways relevant to invasive breast cancer.

  8. The nucleus of a myoblast moves rapidly after fusion towards the central myotube nuclei which is driven by microtubules and dynein/dynactin (show DCTN1 Proteins) complex, and requires Cdc42 (show CDC42 Proteins), Par6 (show PARD6A Proteins) and Par3 (show F2RL2 Proteins).

  9. Data suggest that aPKC phosphorylates JAM-A (show F11R Proteins) at S285 to regulate cell-cell contact maturation, TJ formation, and single lumen specification.

  10. Brain-derived neurotrophic factor (BDNF (show BDNF Proteins)) induces polarized signaling of small GTPase (show RACGAP1 Proteins) (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3 (show F2RL2 Proteins)) protein.

Agouti Signaling Protein (ASIP) Protein Profile

Protein Summary

In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes.

Gene names and symbols associated with ASIP

  • agouti signaling protein (ASIP)
  • agouti signaling protein, nonagouti homolog (mouse) (ASIP)
  • agouti signaling protein (asip)
  • agouti signaling protein (Asip)
  • agouti-signaling protein-like (LOC709156)
  • nonagouti (a)
  • par-3 (partitioning defective 3) homolog (C. elegans) (Pard3)
  • A protein
  • AA960621 protein
  • AGSW protein
  • AGTI protein
  • AGTIL protein
  • AI256638 protein
  • As protein
  • ASIP protein
  • ASP protein
  • D8Ertd580e protein
  • PAR-3 protein
  • Par3 protein
  • Pard3a protein
  • SHEP9 protein

Protein level used designations for ASIP

agouti signaling protein, nonagouti homolog , agouti-signaling protein , agouti signaling protein , ASP , agouti switch protein , nonagouti homolog , agouti signalling protein , Agouti (coat color) , agouti-signaling protein-like , Agouti switch protein , Agouti-signaling protein , agouti coat color protein , agouti signal protein , non-agouti , PARD-3 , PHIP , atypical PKC isotype-specific-interacting protein , ephrin-interacting protein , partitioning defective 3 homolog

GENE ID SPECIES
100440302 Pongo abelii
419147 Gallus gallus
100144328 Oryctolagus cuniculus
100302661 Papio anubis
100431176 Oncorhynchus mykiss
100218186 Taeniopygia guttata
100032347 Monodelphis domestica
404192 Bos taurus
492296 Canis lupus familiaris
434 Homo sapiens
414439 Sus scrofa
24152 Rattus norvegicus
100974762 Pan paniscus
747368 Pan troglodytes
100054335 Equus caballus
100401359 Callithrix jacchus
492297 Felis catus
709156 Macaca mulatta
50518 Mus musculus
93742 Mus musculus
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