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Alcohol Dehydrogenase 5 (Class III), chi Polypeptide Proteins (ADH5)

ADH5 encodes a member of the alcohol dehydrogenase family. Additionally we are shipping Alcohol Dehydrogenase 5 (Class III), chi Polypeptide Antibodies (90) and Alcohol Dehydrogenase 5 (Class III), chi Polypeptide Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ADH5 128 P11766
ADH5 11532 P28474
ADH5 100145871 P12711
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Top Alcohol Dehydrogenase 5 (Class III), chi Polypeptide Proteins at antibodies-online.com

Showing 10 out of 30 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Yeast Human His tag 50 μg Log in to see 31 to 36 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Human GST tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
Yeast Yeast His tag   1 mg Log in to see 56 to 66 Days
$2,942.50
Details
Yeast Candida albicans His tag   1 mg Log in to see 56 to 66 Days
$2,946.17
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,023.17
Details
Yeast Uromastyx hardwickii His tag   1 mg Log in to see 56 to 66 Days
$3,023.17
Details

ADH5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Mouse (Murine)

Rat (Rattus)

Top referenced Alcohol Dehydrogenase 5 (Class III), chi Polypeptide Proteins

  1. Human ADH5 Protein expressed in Escherichia coli (E. coli) - ABIN1098240 : Shimada, Miyagawa, Kawashima, Tanaka, Honda, Honda, Tokunaga: An approach based on a genome-wide association study reveals candidate loci for narcolepsy. in Human genetics 2010 (PubMed)
    Show all 2 references for ABIN1098240

  2. Human ADH5 Protein expressed in Wheat germ - ABIN1305987 : Beigi, Gonzalez, Minhas, Sun, Foster, Khan, Treuer, Dulce, Harrison, Saraiva, Premer, Schulman, Stamler, Hare: Dynamic denitrosylation via S-nitrosoglutathione reductase regulates cardiovascular function. in Proceedings of the National Academy of Sciences of the United States of America 2012 (PubMed)

More Proteins for Alcohol Dehydrogenase 5 (Class III), chi Polypeptide (ADH5) Interaction Partners

Fruit Fly (Drosophila melanogaster) Alcohol Dehydrogenase 5 (Class III), chi Polypeptide (ADH5) interaction partners

Human Alcohol Dehydrogenase 5 (Class III), chi Polypeptide (ADH5) interaction partners

  1. GSNOR expression has different effect on neuronal viability in dependence on the stimulus applied, and plays opposite roles in SH-SY5Y models of Parkinson's disease and amyotrophic lateral sclerosis

  2. ADH5 counteracts neuronal differentiation of neural stem cells and this effect can be reversed by pharmacological inhibition of ADH5.

  3. common ADH (show AVP Proteins) variants conferred risk for both schizophrenia in African-Americans and autism in European-Americans.

  4. A decrease in ADH (show AVP Proteins) IB, rather than GSNOR, correlates with human lung cancer.

  5. study compared individuals occupationally exposed to formaldehyde and controls to effects of XRCC3 (show XRCC3 Proteins) Thr241Met, ADH5 Val309Ile and Asp353Glu polymorphisms; ADH5 polymorphisms did not show significant association with genotoxicity biomarkers

  6. Data suggest that GSNOR deficiency, through dysregulated S-nitrosylation, may promote hepatocellular carcinoma, possibly by inactivating a DNA repair system.

  7. Significant associations were found however, for reactions to alcohol with a SNP in ADH5 (rs6827292, p = .001) and a SNP just upstream of ADH5 (rs6819724, p = .0007) that is in strong LD with rs6827292.

  8. POZ domain of FBI1 (show ZBTB7A Proteins) represses transcription of ADH5.

  9. The structural determination of apo (show C9orf3 Proteins), binary alcohol, and inhibitory ternary FDH complexes provides new insight into the enzyme's metal-assisted catalysis and substrate-binding properties.

  10. Formation of a FDH-S-(hydroxymethyl)glutathione-NADH ternary complex causes movement of glutathione-dependent formaldehyde dehydrogenase catalytic domain toward the coenzyme-binding domain, and a change in active-site zinc coordination.

Mouse (Murine) Alcohol Dehydrogenase 5 (Class III), chi Polypeptide (ADH5) interaction partners

  1. Loss of GSNOR confers enhanced post-MI cardiac regenerative activity, characterized by enhanced turnover of cardiomyocytes and cardiac stem cells.

  2. Results show that ADH5 removes endogenous formaldehyde to prevent DNA adducts, and protects with FANCD2, hematopoietic stem cells, hepatocytes, and nephrons from endogenous DNA damage.

  3. S-nitrosoglutathione reductase-dependent modification of PPARgamma (show PPARG Proteins) alters the balance between adipocyte and osteoblast differentiation and provides checkpoint regulation of the lineage bifurcation of these 2 lineages.

  4. These findings provide novel insights into the involvement of GSNOR and S-nitrosylation in neuromuscular atrophy and neuropathic pain that are associated with pathological states.

  5. Overexpression of ADH5 reduces both development and adult neuronal differentiation of neurons. This effect depends on the catalytic activity of ADH5 and involves ADH5-mediated denitrosation of histone deacetylase 2 (HDAC2 (show HDAC2 Proteins)).

  6. GSNOR appears to play a crucial role in controlling pulmonary and systemic infection by K. pneumoniae.

  7. A critical role for GSNOR in maintaining genomic integrity.

  8. This study suggests that S-nitrosoglutathione reductase degradation of S-nitrosoglutathione is a vital step in the expression of ventilatory roll-off

  9. GSNOR deficiency has a role in hepatocarcinogenesis, which is prevented by iNOS (show NOS2 Proteins) inhibition

  10. Increasing the denitrosylation capacity of cardiomyocytes, via cardiomyocyte-specific overexpression of GSNOR, protects against sepsis-induced myocardial depression.

Arabidopsis thaliana Alcohol Dehydrogenase 5 (Class III), chi Polypeptide (ADH5) interaction partners

  1. polar auxin transport was compromised in gsnor1-3, which was correlated with universally reduced levels of PIN (show DYNLL1 Proteins) or GFP-PIN (show DYNLL1 Proteins) proteins in the roots of the mutant.

  2. Collectively, our findings imply that AtGSNOR1 controls multiple genetic networks integral to plant growth and development.

  3. Taken together, these results suggest that GSNOR1/HOT5/PAR2 plays an important role in regulating cell death in plant cells through modulating intracellular NO level.

  4. S-nitrosoglutathione reductase is an important and widely utilized component of pathogen resistance protein signaling networks conserved in animals and plants.

Alcohol Dehydrogenase 5 (Class III), chi Polypeptide (ADH5) Protein Profile

Protein Summary

This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene.

Gene names and symbols associated with ADH5

  • Formaldehyde dehydrogenase (Fdh)
  • alcohol dehydrogenase 5 (adh5)
  • Alcohol dehydrogenase class-3 (RSKD131_0888)
  • Alcohol dehydrogenase class-3 (adhI)
  • Alcohol dehydrogenase class-3 (adhx)
  • alcohol dehydrogenase 2; same as cosmid orf Ca41C10.04; similar to C. albicans ADH1 (CaP19.3997), P.stipitis ADH2 and S. cerevisiae ADH2 (ADH2)
  • alcohol dehydrogenase 5 (class III), chi polypeptide (ADH5)
  • alcohol dehydrogenase 5 (class III), chi polypeptide (Adh5)
  • alcohol dehydrogenase class-3 (HOT5)
  • formaldehyde dehydrogenase homolog1 (fdh1)
  • ADH-3 protein
  • Adh-5 protein
  • ADH1C protein
  • ADH2 protein
  • Adh3 protein
  • ADHX protein
  • ADHX_DROME protein
  • ALCOHOL DEHYDROGENASE 2 protein
  • ATGSNOR1 protein
  • CG6598 protein
  • Dmel\\CG6598 protein
  • FALDH protein
  • FDH protein
  • gfd protein
  • gfd/odh protein
  • GLUTATHIONE-DEPENDENT FORMALDEHYDE DEHYDROGENASE protein
  • GSH-FDH protein
  • GSNOR protein
  • MRH10.4 protein
  • MRH10_4 protein
  • odh protein
  • PAR2 protein
  • PARAQUAT RESISTANT 2 protein
  • S-NITROSOGLUTATHIONE REDUCTASE protein
  • sensitive to hot temperatures 5 protein
  • wu:fb60b11 protein

Protein level used designations for ADH5

CG6598-PA , Fdh-PA , formaldehyde dehydrogenase , glutathione-dependent formaldehyde dehydrogenase , octanol dehydrogenase , alcohol dehydrogenase class-3 , fb60b11 , Alcohol dehydrogenase class-3 , hypothetical protein , S-(hydroxymethyl)glutathione dehydrogenase , alcohol dehydrogenase (class III), chi polypeptide , alcohol dehydrogenase class chi chain , alcohol dehydrogenase class-III , ADH-B2 , FALDH , FDH , GSH-FDH , S-nitrosoglutathione reductase , alcohol dehydrogenase 2 , alcohol dehydrogenase B2 , class III alcohol dehydrogenase, chi subunit , alcohol dehydrogenase 1C (class I), gamma polypeptide , class III alcohol dehydrogenase , CL1875_1 , CL1875_1_ov , CL1875_1b , IDP332 , fadh1 , glutothione-dependent formaldehyde dehydrogenase

GENE ID SPECIES
41311 Drosophila melanogaster
116517 Danio rerio
7360621 Rhodobacter sphaeroides KD131
9416150 Ralstonia solanacearum CFBP2957
100195992 Salmo salar
3640833 Candida albicans SC5314
128 Homo sapiens
11532 Mus musculus
505515 Bos taurus
100145871 Rattus norvegicus
100009307 Oryctolagus cuniculus
834417 Arabidopsis thaliana
542459 Zea mays
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