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Aldehyde Dehydrogenase 18 Family, Member A1 Proteins (ALDH18A1)

ALDH18A1 is a member of the aldehyde dehydrogenase family and encodes a bifunctional ATP- and NADPH-dependent mitochondrial enzyme with both gamma-glutamyl kinase and gamma-glutamyl phosphate reductase activities. Additionally we are shipping P5CS Antibodies (48) and P5CS Kits (17) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ALDH18A1 5832 P54886
ALDH18A1 56454 Q9Z110
Rat ALDH18A1 ALDH18A1 361755  
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Top P5CS Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

ALDH18A1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Aldehyde Dehydrogenase 18 Family, Member A1 (ALDH18A1) Interaction Partners

Human Aldehyde Dehydrogenase 18 Family, Member A1 (ALDH18A1) interaction partners

  1. autosomal recessive transmission of ALDH18A1 mutations, and predominant complex hereditary spastic paraplegia with marked cognitive impairment

  2. A frameshift deletion of one nucleotide and a microdeletion affecting the ALDH18A1 gene, respectively, in a homozygous state in both patients, was identified.

  3. expansion of the phenotypic spectrum associated with mutations in ALDH18A1

  4. ALDH18A1 genetic variants are associated with Down syndrome in subjects with dementia of Alzheimer's disease.

  5. These data suggest that P5CS may possess additional uncharacterised functions that affect connective tissue and central nervous system function.

P5CS (ALDH18A1) Protein Profile

Protein Summary

This gene is a member of the aldehyde dehydrogenase family and encodes a bifunctional ATP- and NADPH-dependent mitochondrial enzyme with both gamma-glutamyl kinase and gamma-glutamyl phosphate reductase activities. The encoded protein catalyzes the reduction of glutamate to delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline, ornithine and arginine. Mutations in this gene lead to hyperammonemia, hypoornithinemia, hypocitrullinemia, hypoargininemia and hypoprolinemia and may be associated with neurodegeneration, cataracts and connective tissue diseases. Alternatively spliced transcript variants, encoding different isoforms, have been described for this gene.

Gene names and symbols associated with ALDH18A1

  • aldehyde dehydrogenase 18 family, member A1 (ALDH18A1)
  • aldehyde dehydrogenase 18 family, member A1 (aldh18a1)
  • aldehyde dehydrogenase 18 family, member A1 (Aldh18a1)
  • 2810433K04Rik protein
  • AI429789 protein
  • ALDH18A1 protein
  • ARCL3A protein
  • cb842 protein
  • cb899 protein
  • GSAS protein
  • P5CS protein
  • pycs protein
  • sb:cb881 protein
  • wu:fa91f10 protein
  • wu:fi05f11 protein
  • wu:fi17d12 protein

Protein level used designations for ALDH18A1

pyrroline-5-carboxylate synthetase , aldehyde dehydrogenase 18 family, member A1 , Delta-1-pyrroline-5-carboxylate synthetase , P5CS , aldehyde dehydrogenase 18A1 , aldehyde dehydrogenase family 18 member A1 , delta-1-pyrroline-5-carboxylate synthase , aldehyde dehydrogenase 18A1-like , delta-1-pyrroline-5-carboxylate synthetase , delta1-pyrroline-5-carboxlate synthetase , pyrroline-5-carboxylate synthetase (glutamate gamma-semialdehyde synthetase) , glutamate gamma-semialdehyde synthetase

GENE ID SPECIES
450629 Pan troglodytes
550060 Xenopus (Silurana) tropicalis
703357 Macaca mulatta
100061213 Equus caballus
100173488 Pongo abelii
100375273 Saccoglossus kowalevskii
5832 Homo sapiens
56454 Mus musculus
361755 Rattus norvegicus
557186 Danio rerio
444469 Xenopus laevis
423976 Gallus gallus
477781 Canis lupus familiaris
514759 Bos taurus
100151977 Sus scrofa
100352530 Oryctolagus cuniculus
100716882 Cavia porcellus
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