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Aldehyde Dehydrogenase 2 Family (Mitochondrial) Proteins (ALDH2)

This protein belongs to the aldehyde dehydrogenase family of proteins. Additionally we are shipping Aldehyde Dehydrogenase 2 Family (Mitochondrial) Antibodies (153) and Aldehyde Dehydrogenase 2 Family (Mitochondrial) Kits (23) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ALDH2 217 P05091
ALDH2 29539 P11884
ALDH2 11669 P47738
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Top Aldehyde Dehydrogenase 2 Family (Mitochondrial) Proteins at antibodies-online.com

Showing 10 out of 15 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 2 to 3 Days
$320.25
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 7 to 8 Days
$242.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Leishmania tarentolae His tag   1 mg Log in to see 56 to 66 Days
$3,384.33
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,415.50
Details
Yeast Horse His tag   1 mg Log in to see 56 to 66 Days
$3,417.33
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,417.33
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$3,417.33
Details

ALDH2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Rat (Rattus)

Mouse (Murine)

Top referenced Aldehyde Dehydrogenase 2 Family (Mitochondrial) Proteins

  1. Human ALDH2 Protein expressed in Escherichia coli (E. coli) - ABIN666745 : Crabb, Edenberg, Bosron, Li: Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2(2) allele is dominant. in The Journal of clinical investigation 1989 (PubMed)
    Show all 2 references for ABIN666745

More Proteins for Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) Interaction Partners

Rabbit Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) interaction partners

  1. ALDH-2 is involved in the remote ischemic preconditioning pathway.

Human Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) interaction partners

  1. Polymorphisms on ADH1B (show ADH1B Proteins) and ALDH2 had significant indirect effects on hepatocellular carcinoma risk, mediated through alcohol drinking

  2. alcohol dehydrogenase 1B (class I) beta polypeptide alcohol dehydrogenase 1B (show ADH1B Proteins) ADH beta subunit (show ADH1B Proteins) alcohol dehydrogenase 2 (class I) beta polypeptide (show ADH1B Proteins) alcohol dehydrogenase subunit beta (show ADH1B Proteins) aldehyde reductase (show ADH1B Proteins) epididymis secretory protein Li 117

  3. Genetic Analysis of the ZNF512B, SLC41A1, and ALDH2 Polymorphisms in Parkinson's Disease in the Iranian Population.

  4. The high prevalence of ALDH2*2 allele in East Asian populations may have important public health implications and may be utilized to reduce the occurrence of alcohol-related cancers among East Asians

  5. epsilonPKC phosphorylation and its coevolution with ALDH2 play an important role in the regulation and protection of ALDH2 enzyme activity.

  6. Here we provide examples why patients with an ALDH2*2 variant need more individualized medical management which is becoming a more standard practice in the precision medicine era.

  7. Study indicate that ALDH2 Glu487Lys and CYP4502E1 polymorphisms could be risk factors for the development of gastric cancer in the Chinese population.

  8. ADH1B (show ADH1B Proteins) rs1229984 and ALDH2 rs671 polymorphisms increased the risk of Alzheimer's disease in all the genetic models.

  9. ADH1B (show ADH1B Proteins) Arg47His polymorphism, but not the ALDH2 Glu487Lys variation, may influence development of colorectal cancer in the Chinese population.

  10. We produced ALDH2-deficient mice that showed elevated plasma acetaldehyde levels and increased airway obstruction after they were administered an oral dose of ethanol, and we demonstrated that symptoms resembling alcohol-induced asthma were easily induced in this mouse model system.

Cow (Bovine) Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) interaction partners

  1. ACADM (show ACADM Proteins) and ALDH2 were predicted to be the target genes of miR (show MYLIP Proteins)-224

  2. analysis of bioactivation of nitroglycerin by purified mitochondrial and cytosolic aldehyde dehydrogenases ALDH1 (show ALDH1A1 Proteins) and ALDH2

Mouse (Murine) Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) interaction partners

  1. ALDH2 activation is adequate to improve the autophagy flux by reducing the carbonyl modification on SIRT1 (show SIRT1 Proteins), which in turn plays an important role in maintaining cardiac health during aging.

  2. Our findings provide new insight into the preventive role of oesophageal ALDH2 against acetaldehyde-derived DNA damage.

  3. High concentrations of ETBE might result in reproductive toxicity in mice with normal active ALDH2, while low active/inactive ALDH2 significantly enhanced the ETBE-induced reproductive toxicity in mice.

  4. ALDH2 deficiency enhances ethanol-induced disruption of intestinal epithelial tight junctions.

  5. In mice lacking ALDH2, there would be increases in 4-hydroxynonenal and the appearance of Alzheimer's disease-like pathological changes.

  6. Mitochondrial aldehyde dehydrogenase 2 plays protective roles in heart failure after myocardial infarction via suppression of the cytosolic JNK (show MAPK8 Proteins)/p53 (show TP53 Proteins) pathway in mice.

  7. ALDH2 functions as a tumor suppressor by maintaining genomic stability in the liver, and the common human ALDH2 variant would present a significant risk factor for hepatocarcinogenesis.

  8. ALDH2 activation, Alda-1, inhibited atherosclerosis and attenuated NAFLD in apoE (show APOE Proteins)(-/-) mice.

  9. Findings suggest that miR (show MLXIP Proteins)-28 promotes myocardial ischemia through the inhibition of ALDH2 expression in mus (show TRPV6 Proteins).

  10. Rutin increased ALDH2 expression, while daidzin reversed this beneficial effect. Thus, this study demonstrates rutin protects HT22 cells against ethanol-induced neurotoxicity by increasing ALDH2 activity.

Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) Protein Profile

Protein Summary

This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with ALDH2

  • aldehyde dehydrogenase 2, tandem duplicate 1 (aldh2.1)
  • aldehyde dehydrogenase 2 family (mitochondrial) (aldh2)
  • aldehyde dehydrogenase 2 family (mitochondrial) (ALDH2)
  • aldehyde dehydrogenase2 (aldh2)
  • aldehyde dehydrogenase, mitochondrial-like (ALDH2)
  • aldehyde dehydrogenase (aldH2)
  • aldehyde dehydrogenase (NAD(+)) (aldH2)
  • aldehyde dehydrogenase 2 family (mitochondrial) (LOC100217978)
  • aldehyde dehydrogenase 2 family (mitochondrial) (Aldh2)
  • aldehyde dehydrogenase 2, mitochondrial (Aldh2)
  • Ahd-5 protein
  • Ahd5 protein
  • ALDH-E2 protein
  • aldh2 protein
  • aldh2a protein
  • ALDHI protein
  • ALDM protein
  • MGC80785 protein
  • rf2b protein
  • zgc:63786 protein

Protein level used designations for ALDH2

aldehyde dehydrogenase 2 , aldehyde dehydrogenase 2 family (mitochondrial) , aldehyde dehydrogenase 2 family (mitochondrial)a , aldehyde dehydrogenase 2.1 , mitochondrial aldehyde dehydrogenase 2 , ALDH2B6 , mitochondrial aldehyde dehydrogenase RF2B , aldehyde dehydrogenase , aldehyde dehydrogenase (NAD(+)) , ALDH class 2 , ALDH-E2 , aldehyde dehydrogenase, mitochondrial , aldehyde dehydrogenase, mitochondrial-like , acetaldehyde dehydrogenase 2 , liver mitochondrial ALDH , nucleus-encoded mitochondrial aldehyde dehydrogenase 2 , ALDH1 , aldehyde dehydrogenase 2, mitochondrial , mitochondrial aldehyde dehydrogenase , ALDHI , AHD-M1

GENE ID SPECIES
393462 Danio rerio
446857 Xenopus laevis
448267 Xenopus (Silurana) tropicalis
452252 Pan troglodytes
542567 Zea mays
713451 Macaca mulatta
4226489 Rhodococcus jostii RHA1
5776113 Staphylococcus aureus subsp. aureus USA300_TCH1516
5952690 Halobacterium salinarum R1
9005267 Rhodobacter capsulatus SB 1003
100171596 Pongo abelii
100217978 Taeniopygia guttata
100338523 Oryctolagus cuniculus
100388478 Callithrix jacchus
217 Homo sapiens
29539 Rattus norvegicus
610941 Canis lupus familiaris
733685 Sus scrofa
508629 Bos taurus
416880 Gallus gallus
11669 Mus musculus
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