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Aldehyde Dehydrogenase 2 Family (Mitochondrial) Proteins (ALDH2)

This protein belongs to the aldehyde dehydrogenase family of proteins. Additionally we are shipping Aldehyde Dehydrogenase 2 Family (Mitochondrial) Antibodies (143) and Aldehyde Dehydrogenase 2 Family (Mitochondrial) Kits (20) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ALDH2 217 P05091
ALDH2 29539 P11884
ALDH2 11669 P47738
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Top Aldehyde Dehydrogenase 2 Family (Mitochondrial) Proteins at antibodies-online.com

Showing 10 out of 15 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 2 to 3 Days
$320.25
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 7 to 8 Days
$242.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Leishmania tarentolae His tag   1 mg Log in to see 56 to 66 Days
$3,384.33
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,415.50
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$3,417.33
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,417.33
Details
Yeast Horse His tag   1 mg Log in to see 56 to 66 Days
$3,417.33
Details

ALDH2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Rat (Rattus)

Mouse (Murine)

Top referenced Aldehyde Dehydrogenase 2 Family (Mitochondrial) Proteins

  1. Human ALDH2 Protein expressed in Escherichia coli (E. coli) - ABIN666745 : Crabb, Edenberg, Bosron, Li: Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2(2) allele is dominant. in The Journal of clinical investigation 1989 (PubMed)
    Show all 2 references for ABIN666745

More Proteins for Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) Interaction Partners

Rabbit Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) interaction partners

  1. ALDH-2 is involved in the remote ischemic preconditioning pathway.

Human Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) interaction partners

  1. ALDH2 polymorphism has a significant impact on human health[review]

  2. population-level instrumental variable estimation (utilizing interaction of rs671 in ALDH2 and sex as an instrument) strengthens causal inference regarding the largely adverse influence of alcohol intake on cardiovascular health in an Asian population.

  3. the combination of genotypes ADH2 * 2, CYP2E1 (show CYP2E1 Proteins) * 1 combined with genotype homozygous ALDH2 * 1 found in this study could be leading to the population to a potential risk to alcoholism.

  4. Tthe ALDH2*2 allele is associated with a risk for nonalcoholic fatty liver disease in relation to an elevated gamma-glutamyl transferase level.

  5. The results show that the variant rs671 in ALDH2 is associated with an increased risk of coronary artery disease in southern Chinese, while not in northern Chinese.

  6. The genotype frequencies of ALDH2 polymorphisms were 62.6, 32.7, and 4.7% for *1/*1, *1/*2, and *2/*2, respectively. Systolic blood pressure and diastolic blood pressure in the *1/*2 or *2/*2 group were significantly lower than those in the *1/*1 group.

  7. suggested that having the ADH1B (show ADH1B Proteins)*2/*2 genotype caused a positive reaction in subjects with the ALDH2*1/*1 genotype

  8. Evidence suggests that ALDH2 Glu504Lys SNP is a potential candidate genetic risk factor for a variety of chronic diseases such as cardiovascular disease, cancer, and late-onset Alzheimer's disease.

  9. many types of cancers are associated with ALDH2 mutation, such as hepatocellular carcinoma, gastric cancer, and colon cancer; there may be a connection between the single nucleotide polymorphism of ALDH2 rs671 and these cancers

  10. patients with the G-allele displayed retarded methylation readjustment and no change in ALDH2 protein levels.

Cow (Bovine) Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) interaction partners

  1. analysis of bioactivation of nitroglycerin by purified mitochondrial and cytosolic aldehyde dehydrogenases ALDH1 (show ALDH1A1 Proteins) and ALDH2

Mouse (Murine) Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) interaction partners

  1. Our findings provide new insight into the preventive role of oesophageal ALDH2 against acetaldehyde-derived DNA damage.

  2. High concentrations of ETBE might result in reproductive toxicity in mice with normal active ALDH2, while low active/inactive ALDH2 significantly enhanced the ETBE-induced reproductive toxicity in mice.

  3. ALDH2 deficiency enhances ethanol-induced disruption of intestinal epithelial tight junctions.

  4. In mice lacking ALDH2, there would be increases in 4-hydroxynonenal and the appearance of Alzheimer's disease-like pathological changes.

  5. Mitochondrial aldehyde dehydrogenase 2 plays protective roles in heart failure after myocardial infarction via suppression of the cytosolic JNK (show MAPK8 Proteins)/p53 (show TP53 Proteins) pathway in mice.

  6. ALDH2 functions as a tumor suppressor by maintaining genomic stability in the liver, and the common human ALDH2 variant would present a significant risk factor for hepatocarcinogenesis.

  7. ALDH2 activation, Alda-1, inhibited atherosclerosis and attenuated NAFLD in apoE (show APOE Proteins)(-/-) mice.

  8. Findings suggest that miR (show MLXIP Proteins)-28 promotes myocardial ischemia through the inhibition of ALDH2 expression in mus (show TRPV6 Proteins).

  9. Rutin increased ALDH2 expression, while daidzin reversed this beneficial effect. Thus, this study demonstrates rutin protects HT22 cells against ethanol-induced neurotoxicity by increasing ALDH2 activity.

  10. Alda-89 reduced acetaldehyde-induced behavioral impairment by causing a rapid reduction in blood ethanol and acetaldehyde levels after acute ethanol intoxication in both wild-type and ALDH2-deficient, ALDH2*1/*2, heterozygotic knock-in mice

Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) Protein Profile

Protein Summary

This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with ALDH2

  • aldehyde dehydrogenase 2, tandem duplicate 1 (aldh2.1)
  • aldehyde dehydrogenase 2 family (mitochondrial) (aldh2)
  • aldehyde dehydrogenase 2 family (mitochondrial) (ALDH2)
  • aldehyde dehydrogenase2 (aldh2)
  • aldehyde dehydrogenase, mitochondrial-like (ALDH2)
  • aldehyde dehydrogenase (aldH2)
  • aldehyde dehydrogenase (NAD(+)) (aldH2)
  • aldehyde dehydrogenase 2 family (mitochondrial) (LOC100217978)
  • aldehyde dehydrogenase 2 family (mitochondrial) (Aldh2)
  • aldehyde dehydrogenase 2, mitochondrial (Aldh2)
  • Ahd-5 protein
  • Ahd5 protein
  • ALDH-E2 protein
  • aldh2 protein
  • aldh2a protein
  • ALDHI protein
  • ALDM protein
  • MGC80785 protein
  • rf2b protein
  • zgc:63786 protein

Protein level used designations for ALDH2

aldehyde dehydrogenase 2 , aldehyde dehydrogenase 2 family (mitochondrial) , aldehyde dehydrogenase 2 family (mitochondrial)a , aldehyde dehydrogenase 2.1 , mitochondrial aldehyde dehydrogenase 2 , ALDH2B6 , mitochondrial aldehyde dehydrogenase RF2B , aldehyde dehydrogenase , aldehyde dehydrogenase (NAD(+)) , ALDH class 2 , ALDH-E2 , aldehyde dehydrogenase, mitochondrial , aldehyde dehydrogenase, mitochondrial-like , acetaldehyde dehydrogenase 2 , liver mitochondrial ALDH , nucleus-encoded mitochondrial aldehyde dehydrogenase 2 , ALDH1 , aldehyde dehydrogenase 2, mitochondrial , mitochondrial aldehyde dehydrogenase , ALDHI , AHD-M1

GENE ID SPECIES
393462 Danio rerio
446857 Xenopus laevis
448267 Xenopus (Silurana) tropicalis
452252 Pan troglodytes
542567 Zea mays
713451 Macaca mulatta
4226489 Rhodococcus jostii RHA1
5776113 Staphylococcus aureus subsp. aureus USA300_TCH1516
5952690 Halobacterium salinarum R1
9005267 Rhodobacter capsulatus SB 1003
100171596 Pongo abelii
100217978 Taeniopygia guttata
100338523 Oryctolagus cuniculus
100388478 Callithrix jacchus
217 Homo sapiens
29539 Rattus norvegicus
610941 Canis lupus familiaris
733685 Sus scrofa
508629 Bos taurus
416880 Gallus gallus
11669 Mus musculus
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