Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
AKR1B1 encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. Additionally we are shipping Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase) Kits (24) and Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase) Proteins (19) and many more products for this protein.
Showing 10 out of 106 products:
Human Polyclonal AKR1B1 Primary Antibody for IF, IHC (p) - ABIN389205
Steuber, Heine, Podjarny, Klebe: Merging the binding sites of aldose and aldehyde reductase for detection of inhibitor selectivity-determining features. in Journal of molecular biology 2008
Show all 3 references for ABIN389205
Human Polyclonal AKR1B1 Primary Antibody for EIA, IHC (p) - ABIN357881
Gleissner, Sanders, Nadler, Ley: Upregulation of aldose reductase during foam cell formation as possible link among diabetes, hyperlipidemia, and atherosclerosis. in Arteriosclerosis, thrombosis, and vascular biology 2008
Show all 3 references for ABIN357881
Human Polyclonal AKR1B1 Primary Antibody for EIA, IF - ABIN357880
Grundmann, Bohn, Obermeier, Amann: Cloning and prokaryotic expression of a biologically active human placental aldose reductase. in DNA and cell biology 1990
Show all 3 references for ABIN357880
Human Polyclonal AKR1B1 Primary Antibody for IHC, ELISA - ABIN184795
Fujii, Hamaoka, Matsumoto, Fujii, Yamaguchi, Egashira, Miyoshi, Niikawa, Taniguchi: The structural organization of the human aldehyde reductase gene, AKR1A1, and mapping to chromosome 1p33-->p32. in Cytogenetics and cell genetics 1999
Structure of ALR1 in ternary complex with NADPH (show NQO1 Antibodies) and 3,5-dichlorosalicylic acid is reported as well as the implications for inhibitor binding and selectivity.
L-idose is the best alternative to D-glucose in studies on aldose reductase.
prostaglandin F synthase (show AKR1C3 Antibodies) activity of human and bovine aldo-keto reductases
Aldose reductase acts as a switch which can regulate microglia by polarizing cells after spinal cord injury.
Aldose reductase contributes to diabetes-mediated mitochondrial dysfunction and damage through the activation of p53 (show TP53 Antibodies).
Data indicate that inhibition of AR alleviates the MCD (show MLYCD Antibodies) diet-induced liver inflammation and fibrosis in db/db (show LEPR Antibodies) mice, probably through dampening CYP2E1 (show CYP2E1 Antibodies) mediated-oxidative stress and ameliorating the expression of pro-inflammatory cytokines.
FMHM suppressed the activity of AR-dependent phospholipase C (show PLC Antibodies)/protein (show HNRNPC Antibodies) kinase C (show PKC Antibodies) signaling, which further resulted in downstream inactivation of the IkappaB kinase (show CHUK Antibodies)/IkappaB/nuclear factor-kappa B inflammatory pathway.
Allergen-induced airway remodeling is mediated by AR and its inhibition blocks the progression of remodeling via inhibiting TGFbeta1 (show TGFB1 Antibodies)-induced Smad (show SMAD1 Antibodies)-independent and PI3K/AKT (show AKT1 Antibodies)/GSK3beta (show GSK3b Antibodies)-dependent pathway.
BGG-mediated inhibition of aldose reductase prevented LPS (show TLR4 Antibodies)-induced activation of JNK (show MAPK8 Antibodies).
The crystal structure of AKR1a4 in its apo (show C9orf3 Antibodies) form at high resolution.
crystal of AKR1B3 was tetragonal, belonging to space group P4(1)2(1)2 or P4(3)2(1)2, with unit-cell parameters a = b = 107.62, c = 120.76 A
the role of AKR1B3 in regulating advanced glycosylation end products and advanced lipoxidation end products
a Y48F/H110F double mutant of AKR1B3 completely lost PGDS (show PTGDS Antibodies) activity and showed only 2.9% of PGFS (show AKR1C3 Antibodies) activity
Aberrant DNA methylation (show HELLS Antibodies) of AKR1B1 could be potential screening markers of colorectal cancer.
-106T allele of AKR1B1 C-106T polymorphism may be associated with increased risk for essential hypertension in Chinese Han population.
These findings suggest a statistically significant association of AKR1B1 -106C>T polymorphism with retinopathy in North Indian patients
ALR (show GFER Antibodies) C(-106)T polymorphism was not associated with an increased risk of Diabetic Retinopathy; subgroup analysis showed a genetic association between ALR (show GFER Antibodies) C(-106)T polymorphism and the risk of Diabetic Retinopathy of type 1 Diabetes but not Diabetic Retinopathy of type 2 Diabetes(Meta-Analysis)
Higher expression of PLA2G2A (show PLA2G2A Antibodies), PTGS2 (show PTGS2 Antibodies), AKR1B1, AKR1C3 (show AKR1C3 Antibodies) and ABCC4 (show ABCC4 Antibodies) was seen in 22-B endometriosis cells.
Data conclude that AKR1B1 and TM6SF1 may serve as candidate methylation biomarkers for early breast cancer detection.
role of the human aldose reductase AKR1B1 in prostaglandin (PG) F2 alpha synthesis in human subcutaneous and omental adipose tissue
One of the most striking changes involved sorbitol dehydrogenase (show SORD Antibodies), a key enzyme in the polyol pathway. Validation studies revealed dramatically increased sorbitol dehydrogenase (show SORD Antibodies) concentrations and activity in adenomas and cancer cell lines, along with important changes in the expression of other enzymes in the same (AKR1B1) and related (KHK (show KHK Antibodies)) pathways.
In type 2 diabetic patients with suboptimal glycaemic control, the z-4 allele of ALR2 (CA)n polymorphism was independently associated with increased susceptibility to cataracts.
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database.
aldo-keto reductase family 1, member B1-like
, aldose reductase
, aldo-keto reductase family 1, member B1 (aldose reductase)
, alcohol dehydrogenase
, alcohol dehydrogenase [NADP(+)]
, aldehyde reductase
, aldo-keto reductase family 1 member A1
, aldo-keto reductase family 1, member A4 (aldehyde reductase)
, 3-DG-reducing enzyme
, Lii5-2 CTCL tumor antigen
, aldehyde reductase 1
, aldo-keto reductase family 1 member B1
, low Km aldose reductase
, 20-alpha-hydroxysteroid dehydrogenase
, Aldehyde reductase 1 (low Km aldose reductase) (5.8 kb PstI fragment, probably the functional gene)
, aldo-keto reductase family 1, member B4 (aldose reductase)