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Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase) Proteins (AKR1B1)

AKR1B1 encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. Additionally we are shipping Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase) Antibodies (100) and Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase) Kits (33) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
AKR1B1 58810 Q9JII6
AKR1B1 78959 P51635
AKR1B1 231 P15121
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Top Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase) Proteins at antibodies-online.com

Showing 10 out of 19 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human Un-conjugated Figure annotation denotes ug of protein loaded and % gel used. 100 μg Log in to see 7 to 9 Days
$358.57
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 7 to 8 Days
$242.00
Details
HOST_Wheat germ Human GST tag   10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 16 Days
$327.80
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,843.50
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$2,843.50
Details
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days
$2,843.50
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,843.50
Details

AKR1B1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus) ,

Human , ,
,

Top referenced Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase) Proteins

  1. Human AKR1B1 Protein expressed in Escherichia coli (E. coli) - ABIN666726 : Donaghue, Margan, Chan, Holloway, Silink, Rangel, Bennetts: The association of aldose reductase gene (AKR1B1) polymorphisms with diabetic neuropathy in adolescents. in Diabetic medicine : a journal of the British Diabetic Association 2005 (PubMed)
    Show all 2 references for ABIN666726

  2. Human AKR1B1 Protein expressed in Wheat germ - ABIN1344744 : Atsriku, Hoffmann, Moghaddam, Kumar, Surapaneni: In vitro metabolism of a novel JNK inhibitor tanzisertib: interspecies differences in oxido-reduction and characterization of enzymes involved in metabolism. in Xenobiotica; the fate of foreign compounds in biological systems 2015 (PubMed)

More Proteins for Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase) (AKR1B1) Interaction Partners

Pig (Porcine) Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase) (AKR1B1) interaction partners

  1. Structure of ALR1 in ternary complex with NADPH (show NQO1 Proteins) and 3,5-dichlorosalicylic acid is reported as well as the implications for inhibitor binding and selectivity.

Cow (Bovine) Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase) (AKR1B1) interaction partners

  1. L-idose is the best alternative to D-glucose in studies on aldose reductase.

  2. prostaglandin F synthase (show AKR1C3 Proteins) activity of human and bovine aldo-keto reductases

Mouse (Murine) Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase) (AKR1B1) interaction partners

  1. Aldose reductase acts as a switch which can regulate microglia by polarizing cells after spinal cord injury.

  2. Aldose reductase contributes to diabetes-mediated mitochondrial dysfunction and damage through the activation of p53 (show TP53 Proteins).

  3. Data indicate that inhibition of AR alleviates the MCD (show MLYCD Proteins) diet-induced liver inflammation and fibrosis in db/db (show LEPR Proteins) mice, probably through dampening CYP2E1 (show CYP2E1 Proteins) mediated-oxidative stress and ameliorating the expression of pro-inflammatory cytokines.

  4. FMHM suppressed the activity of AR-dependent phospholipase C (show PLC Proteins)/protein (show HNRNPC Proteins) kinase C signaling, which further resulted in downstream inactivation of the IkappaB kinase (show CHUK Proteins)/IkappaB/nuclear factor-kappa B inflammatory pathway.

  5. Allergen-induced airway remodeling is mediated by AR and its inhibition blocks the progression of remodeling via inhibiting TGFbeta1-induced Smad-independent and PI3K/AKT/GSK3beta-dependent pathway.

  6. BGG-mediated inhibition of aldose reductase prevented LPS (show TLR4 Proteins)-induced activation of JNK (show MAPK8 Proteins).

  7. The crystal structure of AKR1a4 in its apo (show C9orf3 Proteins) form at high resolution.

  8. crystal of AKR1B3 was tetragonal, belonging to space group P4(1)2(1)2 or P4(3)2(1)2, with unit-cell parameters a = b = 107.62, c = 120.76 A

  9. the role of AKR1B3 in regulating advanced glycosylation end products and advanced lipoxidation end products

  10. a Y48F/H110F double mutant of AKR1B3 completely lost PGDS (show PTGDS Proteins) activity and showed only 2.9% of PGFS (show AKR1C3 Proteins) activity

Human Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase) (AKR1B1) interaction partners

  1. ALR (show GFER Proteins) C(-106)T polymorphism was not associated with an increased risk of Diabetic Retinopathy; subgroup analysis showed a genetic association between ALR (show GFER Proteins) C(-106)T polymorphism and the risk of Diabetic Retinopathy of type 1 Diabetes but not Diabetic Retinopathy of type 2 Diabetes(Meta-Analysis)

  2. Higher expression of PLA2G2A, PTGS2, AKR1B1, AKR1C3 and ABCC4 was seen in 22-B endometriosis cells.

  3. Data conclude that AKR1B1 and TM6SF1 may serve as candidate methylation biomarkers for early breast cancer detection.

  4. L-idose is the best alternative to D-glucose in studies on aldose reductase.

  5. role of the human aldose reductase AKR1B1 in prostaglandin (PG) F2 alpha synthesis in human subcutaneous and omental adipose tissue

  6. One of the most striking changes involved sorbitol dehydrogenase (show SORD Proteins), a key enzyme in the polyol pathway. Validation studies revealed dramatically increased sorbitol dehydrogenase (show SORD Proteins) concentrations and activity in adenomas and cancer cell lines, along with important changes in the expression of other enzymes in the same (AKR1B1) and related (KHK (show KHK Proteins)) pathways.

  7. In type 2 diabetic patients with suboptimal glycaemic control, the z-4 allele of ALR2 (CA)n polymorphism was independently associated with increased susceptibility to cataracts.

  8. prostaglandin F synthase (show AKR1C3 Proteins) activity of human and bovine aldo-keto reductases

  9. Aldose reductase contributes to diabetes-mediated mitochondrial dysfunction and damage through the activation of p53 (show TP53 Proteins).

  10. Aldose reductase gene may not be significantly associated with diabetic retinopathy in Chinese patients with type 2 diabetes mellitus.

Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase) (AKR1B1) Protein Profile

Protein Summary

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database.

Gene names and symbols associated with AKR1B1

  • aldo-keto reductase family 1, member B1 (aldose reductase) (AKR1B1)
  • aldo-keto reductase family 1, member B1 (aldose reductase) (akr1b1)
  • aldo-keto reductase family 1, member B1-like (aldose reductase) (AKR1B1L)
  • aldo-keto reductase family 1, member A1 (aldehyde reductase) (AKR1A1)
  • aldo-keto reductase family 1, member A1 (aldehyde reductase) (Akr1a1)
  • aldo-keto reductase family 1, member B1 (aldose reductase) (Akr1b1)
  • aldo-keto reductase family 1, member B3 (aldose reductase) (Akr1b3)
  • 2610201A18Rik protein
  • ADR protein
  • Ahr-1 protein
  • Ahr1 protein
  • Akr1a4 protein
  • Akr1b1 protein
  • Akr1b3 protein
  • Akr1b4 protein
  • akr1b7 protein
  • Aldor1 protein
  • Aldr1 protein
  • ALDRED protein
  • Alr protein
  • ALR-P-I protein
  • ALR1 protein
  • ALR2 protein
  • AR protein
  • RATALDRED protein
  • zgc:86611 protein

Protein level used designations for AKR1B1

aldo-keto reductase family 1, member B1-like , aldose reductase , aldo-keto reductase family 1, member B1 (aldose reductase) , alcohol dehydrogenase , alcohol dehydrogenase [NADP(+)] , aldehyde reductase , aldo-keto reductase family 1 member A1 , aldo-keto reductase family 1, member A4 (aldehyde reductase) , 3-DG-reducing enzyme , Lii5-2 CTCL tumor antigen , aldehyde reductase 1 , aldo-keto reductase family 1 member B1 , low Km aldose reductase , 20-alpha-HSD , 20-alpha-hydroxysteroid dehydrogenase , AR , Aldehyde reductase 1 (low Km aldose reductase) (5.8 kb PstI fragment, probably the functional gene) , aldo-keto reductase family 1, member B4 (aldose reductase)

GENE ID SPECIES
737737 Pan troglodytes
398904 Xenopus laevis
418171 Gallus gallus
705957 Macaca mulatta
100585224 Nomascus leucogenys
396924 Sus scrofa
618607 Bos taurus
58810 Mus musculus
78959 Rattus norvegicus
231 Homo sapiens
415138 Danio rerio
607537 Canis lupus familiaris
396816 Sus scrofa
317748 Bos taurus
100009122 Oryctolagus cuniculus
24192 Rattus norvegicus
100718017 Cavia porcellus
101120824 Ovis aries
11677 Mus musculus
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