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anti-Aldo-Keto Reductase Family 1, Member D1 (AKR1D1) Antibodies

The enzyme encoded by AKR1D1 is responsible for the catalysis of the 5-beta-reduction of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure. Additionally we are shipping Aldo-Keto Reductase Family 1, Member D1 Proteins (13) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
AKR1D1 6718 P51857
AKR1D1 208665 Q8VCX1
AKR1D1 192242 P31210
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Top anti-Aldo-Keto Reductase Family 1, Member D1 Antibodies at antibodies-online.com

Showing 10 out of 40 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB AKR1D1 Antibody (Center) western blot analysis in 293 cell line lysates (35 µg/lane).This demonstrates the AKR1D1 antibody detected the AKR1D1 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB 100 μL Log in to see 8 to 10 Days
$507.83
Details
Human Rabbit Un-conjugated WB AKR1D1 Antibody (Center)  western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the AKR1D1 antibody detected the AKR1D1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated WB Western blot analysis of AKR1D1 over-expressed 293 cell line, cotransfected with AKR1D1 Validated Chimera RNAi used as specificity and loading control. Western Blot analysis of AKR1D1 expression in transfected 293T cell line by AKR1D1 monoclonal antibody (M03), clone 1C2. Lane 1: AKR1D1 transfected lysate(37.4 KDa). Lane 2: Non-transfected lysate. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated WB 400 μL Log in to see 6 Days
$457.14
Details
Human Rabbit APC ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Mouse Un-conjugated RNAi, ELISA, WB Western blot analysis of AKR1D1 over-expressed 293 cell line, cotransfected with AKR1D1 Validated Chimera RNAi (Lane 2) or non-transfected control (Lane 1). Blot probed with AKR1D1 monoclonal antibody (M03), clone 1C2. GAPDH ( 36.1 kDa ) used as specificity and loading control. Detection limit for recombinant GST tagged AKR1D1 is approximately 0.3ng/ml as a capture antibody. 100 μg Log in to see 9 Days
$430.00
Details
Human Mouse Un-conjugated IP, ELISA, WB Western Blot analysis of AKR1D1 expression in transfected 293T cell line by AKR1D1 monoclonal antibody (M01), clone 1A6.Lane 1: AKR1D1 transfected lysate(37.4 KDa).Lane 2: Non-transfected lysate. Immunoprecipitation of AKR1D1 transfected lysate using anti-AKR1D1 monoclonal antibody and Protein A Magnetic Bead , and immunoblotted with AKR1D1 MaxPab rabbit polyclonal antibody. 100 μg Log in to see 9 Days
$430.00
Details

AKR1D1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human ,
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Mouse (Murine)


Rat (Rattus)


Top referenced anti-Aldo-Keto Reductase Family 1, Member D1 Antibodies

  1. Human Polyclonal AKR1D1 Primary Antibody for EIA, WB - ABIN950324 : Drury, Mindnich, Penning: Characterization of disease-related 5beta-reductase (AKR1D1) mutations reveals their potential to cause bile acid deficiency. in The Journal of biological chemistry 2010 (PubMed)
    Show all 3 references for ABIN950324

More Antibodies against Aldo-Keto Reductase Family 1, Member D1 Interaction Partners

Human Aldo-Keto Reductase Family 1, Member D1 (AKR1D1) interaction partners

  1. Impaired NADPH (show NQO1 Antibodies) binding and hydride transfer is the molecular basis for bile acid deficiency in patients with the P133R mutation in AKR1D1.

  2. When different steroid substrates were used in single turnover experiments with AKR1D1.

  3. AKR1D1 generates all 5beta-dihydrosteroids in the C19-C27 steroid series.

  4. Despite having high kchem values with steroid hormones, the kinetic control of AKR1D1 is consistent with the enzyme catalysing the slowest step in the catabolic sequence of steroid hormone transformation in the liver.

  5. Studies indicate that mutations in aldo-keto reductase family 1 (AKR1) enzymes AKR1C1 (show DDH Antibodies) and AKR1C4 (show AKR1C4 Antibodies) are responsible for sexual development dysgenesis and mutations in AKR1D1 are causative in bile-acid deficiency.

  6. Novel homozygous frameshift mutations in the AKR1D1 gene and in the SKIV2L (show SKIV2L Antibodies) gene were found in a family with severe infantile liver disease.

  7. Consistent with AKR1D1's putative role as a driver of the P450 (show CYP2B6 Antibodies) subnetwork, the AKR1D1 3'-UTR (show UTS2R Antibodies) SNP was significantly associated with increased hepatic mRNA expression of multiple P450s

  8. These studies show how a single point mutation in AKR1D1 can introduce HSD (show CHST3 Antibodies) activity with unexpected configurational and stereochemical preference.

  9. all five mutations identified in patients with functional bile acid deficiency strongly affected AKR1D1 enzyme functionality and therefore may be causal for this disease

  10. determined the substrate specificity of homogeneous human recombinant AKR1D1 using C18, C19, C21, and C27 Delta(4)-ketosteroids and assessed the pH-rate dependence of the enzyme.

Aldo-Keto Reductase Family 1, Member D1 (AKR1D1) Antigen Profile

Protein Summary

The enzyme encoded by this gene is responsible for the catalysis of the 5-beta-reduction of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure. Deficiency of this enzyme may contribute to hepatic dysfunction. Three transcript variants encoding different isoforms have been found for this gene. Other variants may be present, but their full-length natures have not been determined yet.

Gene names and symbols associated with AKR1D1

  • 3-oxo-5-beta-steroid 4-dehydrogenase-like (AKR1D1) antibody
  • aldo-keto reductase family 1, member D1 (AKR1D1) antibody
  • aldo-keto reductase family 1, member D1 (Akr1d1) antibody
  • aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) (AKR1D1) antibody
  • 3o5bred antibody
  • CBAS2 antibody
  • SRD5B1 antibody

Protein level used designations for AKR1D1

3-oxo-5-beta-steroid 4-dehydrogenase , delta 4-3-ketosteroid-5-beta-reductase , delta(4)-3-ketosteroid 5-beta-reductase , delta(4)-3-oxosteroid 5-beta-reductase , steroid-5-beta-reductase, beta polypeptide 1 (3-oxo-5 beta-steroid delta 4-dehydrogenase beta 1) , aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) , aldo-keto reductase family 1 member D1 , delta4-3-oxosteroid 5beta-reductase

GENE ID SPECIES
491379 Canis lupus familiaris
6718 Homo sapiens
208665 Mus musculus
192242 Rattus norvegicus
513855 Bos taurus
100008612 Oryctolagus cuniculus
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