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Aldo-Keto Reductase Family 1, Member D1 Proteins (AKR1D1)

The enzyme encoded by AKR1D1 is responsible for the catalysis of the 5-beta-reduction of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure. Additionally we are shipping Aldo-Keto Reductase Family 1, Member D1 Antibodies (40) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
AKR1D1 6718 P51857
AKR1D1 208665 Q8VCX1
AKR1D1 192242 P31210
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Top Aldo-Keto Reductase Family 1, Member D1 Proteins at antibodies-online.com

Showing 9 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 2 to 3 Days
$336.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag   10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,876.50
Details
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days
$2,876.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$364.64
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details
Human Un-conjugated   5 μg Log in to see 6 Days
$168.54
Details

AKR1D1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

Top referenced Aldo-Keto Reductase Family 1, Member D1 Proteins

  1. Human AKR1D1 Protein expressed in Wheat germ - ABIN1344768 : Atsriku, Hoffmann, Moghaddam, Kumar, Surapaneni: In vitro metabolism of a novel JNK inhibitor tanzisertib: interspecies differences in oxido-reduction and characterization of enzymes involved in metabolism. in Xenobiotica; the fate of foreign compounds in biological systems 2015 (PubMed)

More Proteins for Aldo-Keto Reductase Family 1, Member D1 (AKR1D1) Interaction Partners

Human Aldo-Keto Reductase Family 1, Member D1 (AKR1D1) interaction partners

  1. Impaired NADPH (show NQO1 Proteins) binding and hydride transfer is the molecular basis for bile acid deficiency in patients with the P133R mutation in AKR1D1.

  2. When different steroid substrates were used in single turnover experiments with AKR1D1.

  3. AKR1D1 generates all 5beta-dihydrosteroids in the C19-C27 steroid series.

  4. Despite having high kchem values with steroid hormones, the kinetic control of AKR1D1 is consistent with the enzyme catalysing the slowest step in the catabolic sequence of steroid hormone transformation in the liver.

  5. Studies indicate that mutations in aldo-keto reductase family 1 (AKR1) enzymes AKR1C1 (show DDH Proteins) and AKR1C4 (show AKR1C4 Proteins) are responsible for sexual development dysgenesis and mutations in AKR1D1 are causative in bile-acid deficiency.

  6. Novel homozygous frameshift mutations in the AKR1D1 gene and in the SKIV2L gene were found in a family with severe infantile liver disease.

  7. Consistent with AKR1D1's putative role as a driver of the P450 subnetwork, the AKR1D1 3'-UTR SNP was significantly associated with increased hepatic mRNA expression of multiple P450s

  8. These studies show how a single point mutation in AKR1D1 can introduce HSD (show CHST3 Proteins) activity with unexpected configurational and stereochemical preference.

  9. all five mutations identified in patients with functional bile acid deficiency strongly affected AKR1D1 enzyme functionality and therefore may be causal for this disease

  10. determined the substrate specificity of homogeneous human recombinant AKR1D1 using C18, C19, C21, and C27 Delta(4)-ketosteroids and assessed the pH-rate dependence of the enzyme.

Aldo-Keto Reductase Family 1, Member D1 (AKR1D1) Protein Profile

Protein Summary

The enzyme encoded by this gene is responsible for the catalysis of the 5-beta-reduction of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure. Deficiency of this enzyme may contribute to hepatic dysfunction. Three transcript variants encoding different isoforms have been found for this gene. Other variants may be present, but their full-length natures have not been determined yet.

Gene names and symbols associated with AKR1D1

  • 3-oxo-5-beta-steroid 4-dehydrogenase-like (AKR1D1)
  • aldo-keto reductase family 1, member D1 (AKR1D1)
  • aldo-keto reductase family 1, member D1 (Akr1d1)
  • aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) (AKR1D1)
  • 3o5bred protein
  • CBAS2 protein
  • SRD5B1 protein

Protein level used designations for AKR1D1

3-oxo-5-beta-steroid 4-dehydrogenase , delta 4-3-ketosteroid-5-beta-reductase , delta(4)-3-ketosteroid 5-beta-reductase , delta(4)-3-oxosteroid 5-beta-reductase , steroid-5-beta-reductase, beta polypeptide 1 (3-oxo-5 beta-steroid delta 4-dehydrogenase beta 1) , aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) , aldo-keto reductase family 1 member D1 , delta4-3-oxosteroid 5beta-reductase

GENE ID SPECIES
491379 Canis lupus familiaris
6718 Homo sapiens
208665 Mus musculus
192242 Rattus norvegicus
513855 Bos taurus
100008612 Oryctolagus cuniculus
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