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Aldo-keto Reductase Family 1 Member C4 Proteins (AKR1C4)

AKR1C4 encodes a member of the aldo\\/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. Additionally we are shipping AKR1C4 Antibodies (75) and AKR1C4 Kits (11) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
AKR1C4 1109 P17516
AKR1C4    
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Top AKR1C4 Proteins at antibodies-online.com

Showing 8 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 2 to 3 Days
$383.25
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 16 Days
$382.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Macaca fascicularis His tag   1 mg Log in to see 56 to 66 Days
$2,867.33
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$364.64
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

AKR1C4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Macaca fascicularis

Top referenced AKR1C4 Proteins

  1. Human AKR1C4 Protein expressed in Escherichia coli (E. coli) - ABIN667485 : Khanna, Qin, Klisak, Belkin, Sparkes, Cheng et al.: Localization of multiple human dihydrodiol dehydrogenase (DDH1 and DDH2) and chlordecone reductase (CHDR) genes in chromosome 10 by the polymerase chain reaction and fluorescence in situ ... in Genomics 1995 (PubMed)
    Show all 2 references for ABIN667485

More Proteins for Aldo-keto Reductase Family 1 Member C4 (AKR1C4) Interaction Partners

Human Aldo-keto Reductase Family 1 Member C4 (AKR1C4) interaction partners

  1. Studies indicate that mutations in aldo-keto reductase family 1 (AKR1) enzymes AKR1C1 (show DDH Proteins) and AKR1C4 are responsible for sexual development dysgenesis and mutations in AKR1D1 (show AKR1D1 Proteins) are causative in bile-acid deficiency.

  2. In women only, SNPs in AKR1C4 reduced the likelihood of having exhibited paranoid ideation by circa 60%.

  3. Low progesterone levels and a cystine to serine change at position 145 in AKR1C4 gene are associated with manic/hypomanic irritability in males

  4. role of AKR1C4 in the metabolism of testosterone and progesterone via the 5beta-reductase pathway.

  5. Taken together, we conclude that the cell-type-specific expression of DD4 mRNA is regulated by vHNF-1 (show HNF1B Proteins)-C.

  6. the expression level of DD4 mRNA is cooperatively regulated by the amounts of HNF-1 alpha (show HNF1A Proteins), HNF-4 alpha (show HNF4A Proteins) and HNF-4 gamma (show HNF4G Proteins).

  7. Impact of mirtazapine on the activity of a key neurosteroidogenic enzyme, the 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD (show DHRS9 Proteins)), and on the levels of neuroactive steroids in relation to clinical response in depression.

  8. Structure determination of human AKR1C4 and homology modelling of AKR1D1 (show AKR1D1 Proteins) followed by docking experiments were used to explore active site geometries.

AKR1C4 Protein Profile

Protein Summary

This gene encodes a member of the aldo\\/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and\\/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.

Gene names and symbols associated with AKR1C4

  • aldo-keto reductase family 1, member C4 (AKR1C4)
  • 3-alpha-HSD protein
  • C11 protein
  • CDR protein
  • CHDR protein
  • DD-4 protein
  • DD4 protein
  • HAKRA protein

Protein level used designations for AKR1C4

3-alpha-HSD1 , aldo-keto reductase family 1 member C4 , chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4 , dihydrodiol dehydrogenase isozyme DD4 , type I 3-alpha-hydroxysteroid dehydrogenase

GENE ID SPECIES
1109 Homo sapiens
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