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The protein encoded by ALDOA, Aldolase A (fructose-bisphosphate aldolase), is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Additionally we are shipping ALDOA Antibodies (67) and ALDOA Kits (40) and many more products for this protein.
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In vitro and in vivo results demonstrated that ALDOA was associated with proliferation and metastasis of pancreatic cancer cells.
Study shows that PI3K directly coordinates glycolysis with cytoskeletal dynamics in an AKT-independent manner. Growth factors or insulin stimulate the PI3K-dependent activation of Rac, leading to disruption of the actin cytoskeleton, release of filamentous actin-bound aldolase A, and an increase in aldolase activity.
Our results expand the clinical spectrum of aldolase A deficiency to isolated temperature-dependent rhabdomyolysis, and suggest that thermolability may be tissue specific. We also propose a treatment for this severe disease
Study provides evidence supporting a critical functional role of ALDOA in osteosarcoma progression, metastasis and perhaps chemoresistance.
ALDOC (show ALDOC Proteins), Aldolase A (ALDOA) and Aldolase B (show ALDOB Proteins) (ALDOB (show ALDOB Proteins)) activate Wnt (show WNT2 Proteins) signaling.
ALDOA is highly expressed in lung squamous cell carcinoma (LSCC) and its expression level is correlated with LSCC metastasis, grades, differentiation status and poor prognosis.
The expression of ALDOA and/or SULT1A3 is significantly higher.
The results presented here point to ALDA as a factor involved in the regulation of cells proliferation.
The new prognostic biomarkers GRP78 (show HSPA5 Proteins), Fructose-bisphosphate Aldolase A (ALDOA), Carbonic Anhydrase I (CA1 (show CA1 Proteins)) and Peptidyl-prolyl cis-trans isomerase A (show PPIA Proteins) or Cyclophilin A (PPIA (show PPIA Proteins))) provided good survival prediction for TNM (show ODZ1 Proteins) stage I-IV patients.
ALDOA is a target gene of the BACH1 (show BACH1 Proteins) transcription factor according to ChIP-seq analysis in HEK (show EPHA3 Proteins) 293 cells.
The lattice of muscle aldolase contacts corresponded to an increased number of interactions between high-entropy side chains that mitigate the lattice strain incurred upon cryocooling and accompanying mosaic spread increases.
kinetic and structural analyses of fructose-bisphosphate aldolase
Aldolase inhibits WASP/Arp2/3-dependent actin polymerization in vitro
The protein encoded by this gene, Aldolase A (fructose-bisphosphate aldolase), is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Aldolase A deficiency has been associated with myopathy and hemolytic anemia. Alternative splicing and alternative promoter usage results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 3 and 10.
fructose-bisphosphate aldolase A
, aldolase A, fructose-bisphosphate
, aldolase C
, fructose-1,6-bisphosphate triosephosphate-lyase
, lung cancer antigen NY-LU-1
, muscle-type aldolase
, aldolase 1, A isoform