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Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron (By similarity).. Additionally we are shipping ALKBH5 Antibodies (28) and many more products for this protein.
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The ALKBH5 gene may play a role in conferring risk of MDD in the Chinese population.
Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation.
Modelling substrate into the active site of ALKBH5 reveals conserved residues important for recognition and demethylation mechanisms.
findings provide a structural basis for understanding the substrate recognition specificity of Alkbh5 and offer a foundation for selective drug design against AlkB (show ALKBH Proteins) members
ALKBH5 is a RNA demethylase and its action strongly suggests that the reversible methyladenosine modification has fundamental and broad functions in mammalian cells.
ALKBH5 may have a role in the regulation of cellular responses to hypoxia as a class of HIF-transcriptional target gene
Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron (By similarity).
RNA demethylase ALKBH5
, alkylated DNA repair protein alkB homolog 5
, alpha-ketoglutarate-dependent dioxygenase alkB homolog 5
, probable alpha-ketoglutarate-dependent dioxygenase ABH5
, oxoglutarate and iron-dependent oxygenase domain containing