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anti-AlkB, Alkylation Repair Homolog 8 (E. Coli) (ALKBH8) Antibodies

Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA. Additionally we are shipping ALKBH8 Proteins (4) and ALKBH8 Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ALKBH8 91801 Q96BT7
ALKBH8 67667 Q80Y20
ALKBH8    
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Top anti-ALKBH8 Antibodies at antibodies-online.com

Showing 10 out of 41 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-ALKBH8 Antibody Titration: 1.0ug/mlPositive Control: Jurkat cell lysate WB Suggested Anti-ALKBH8  Antibody Titration: 1.0 µg/mL  Positive Control: Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Formalin-fixed and paraffin-embedded human spleen reacted with ALKBH8 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Western blot analysis of ALKBH8 Antibody (C-term) (ABIN390773) in HL60 cell line lysates (35 µg/lane). ALKBH8 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 8 to 10 Days
$493.17
Details
Human Rabbit Un-conjugated ELISA, WB 100 μg Log in to see 2 to 3 Days
$343.75
Details
Human Rabbit Un-conjugated WB ALKBH8 antibody used at 1 ug/ml to detect target protein. 100 μg Log in to see 3 to 4 Days
$388.93
Details
Human Rabbit Un-conjugated IHC, ELISA, WB   100 μg Log in to see 8 to 10 Days
$390.50
Details
Human Rabbit Un-conjugated FACS, IHC, ELISA, WB 400 μL Log in to see 6 Days
$457.14
Details
Human Rabbit Alexa Fluor 555 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details

ALKBH8 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-ALKBH8 Antibodies

  1. Human Polyclonal ALKBH8 Primary Antibody for EIA, WB - ABIN452732 : Shimada, Nakamura, Anai, De Velasco, Tanaka, Tsujikawa, Ouji, Konishi: A novel human AlkB homologue, ALKBH8, contributes to human bladder cancer progression. in Cancer research 2009 (PubMed)

  2. Cow (Bovine) Polyclonal ALKBH8 Primary Antibody for WB - ABIN2776625 : Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: Complete sequencing and characterization of 21,243 full-length human cDNAs. ... in Nature genetics 2003 (PubMed)

More Antibodies against ALKBH8 Interaction Partners

Human AlkB, Alkylation Repair Homolog 8 (E. Coli) (ALKBH8) interaction partners

  1. Many euk (show ALKBH Antibodies)aryotic tRNAs contain the wobble modification 5-m (show MCM5 Antibodies)ethoxycarbonylmethyl-uridine (mcm5U). It is demonstrated that (R)- and (S)-5-methoxycarbonylhydroxymethyluridine (mchm5U), hydroxylated forms of mcm(5)U, are present in mammalian tRNA-Arg(UCG), and tRNA-Gly(UCC), respectively. It is shown that the hydroxylation reaction leading to the formation of (S)-mchm5U is catalyzed by the oxygenase (AlkB) domain of ALKBH8.

  2. The methyltransferase domain of ALKBH8 is demonstrated to be a functional homologue of the Saccharomyces cerevisiae Trm9 protein, mediating the last step in the formation of the wobble uridine modification 5-methoxycarbonylmethyl-uridine in tRNA. This modification is shown to be important for efficient selenoprotein synthesis. ALKBH8 knock-out mice are generated and described.

  3. Data show that human AlkB (show ALKBH Antibodies) homolog 8 (ABH8) catalyzes tRNA methylation to generate 5-methylcarboxymethyl uridine (mcm(5 (show MCM5 Antibodies))U) at the wobble position of certain tRNAs, a critical anticodon loop modification linked to DNA damage survival.

  4. Findings indicate a role for ALKBH8 in urothelial carcinoma cell survival mediated by NOX-1 (show NOX1 Antibodies)-dependent ROS (show ROS1 Antibodies) signals, further suggesting therapeutic strategies in human bladder cancer by inducing JNK (show MAPK8 Antibodies)/p38 (show CRK Antibodies)/gammaH2AX (show H2AFX Antibodies)-mediated cell death by silencing of ALKBH8.

Mouse (Murine) AlkB, Alkylation Repair Homolog 8 (E. Coli) (ALKBH8) interaction partners

  1. Alkbh8 and tRNA modifications as central regulators of cellular oxidative stress responses in mammalian systems.

  2. The AlkB (show ALKBH Antibodies) domain of ALKBH8 specifically hydroxylates mcm(5 (show MCM5 Antibodies))U into (S)-mchm(5)U in tRNA-Gly(UCC).

  3. Data show that ALKBH8 is a tRNA methyltransferase required for the final step in the biogenesis of mcm5U.

ALKBH8 Antigen Profile

Protein Summary

Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis (By similarity).

Gene names and symbols associated with ALKBH8

  • alkB, alkylation repair homolog 8 (E. coli) (ALKBH8) antibody
  • alkB, alkylation repair homolog 8 (E. coli) (Alkbh8) antibody
  • 4930562C03Rik antibody
  • 8030431D03Rik antibody
  • 9430088N01Rik antibody
  • Abh8 antibody

Protein level used designations for ALKBH8

AlkB homologue 8 , S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8 , alkylated DNA repair protein alkB homolog 8 , probable alpha-ketoglutarate-dependent dioxygenase ABH8 , tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8

GENE ID SPECIES
91801 Homo sapiens
489424 Canis lupus familiaris
781788 Bos taurus
67667 Mus musculus
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