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AlkB, Alkylation Repair Homolog 8 (E. Coli) Proteins (ALKBH8)

Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA. Additionally we are shipping ALKBH8 Antibodies (41) and ALKBH8 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ALKBH8 91801 Q96BT7
ALKBH8 67667 Q80Y20
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Top ALKBH8 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

ALKBH8 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for AlkB, Alkylation Repair Homolog 8 (E. Coli) (ALKBH8) Interaction Partners

Human AlkB, Alkylation Repair Homolog 8 (E. Coli) (ALKBH8) interaction partners

  1. Many euk (show ALKBH Proteins)aryotic tRNAs contain the wobble modification 5-m (show MCM5 Proteins)ethoxycarbonylmethyl-uridine (mcm5U). It is demonstrated that (R)- and (S)-5-methoxycarbonylhydroxymethyluridine (mchm5U), hydroxylated forms of mcm(5)U, are present in mammalian tRNA-Arg(UCG), and tRNA-Gly(UCC), respectively. It is shown that the hydroxylation reaction leading to the formation of (S)-mchm5U is catalyzed by the oxygenase (AlkB) domain of ALKBH8.

  2. The methyltransferase domain of ALKBH8 is demonstrated to be a functional homologue of the Saccharomyces cerevisiae Trm9 protein, mediating the last step in the formation of the wobble uridine modification 5-methoxycarbonylmethyl-uridine in tRNA. This modification is shown to be important for efficient selenoprotein synthesis. ALKBH8 knock-out mice are generated and described.

  3. Data show that human AlkB (show ALKBH Proteins) homolog 8 (ABH8) catalyzes tRNA methylation to generate 5-methylcarboxymethyl uridine (mcm(5 (show MCM5 Proteins))U) at the wobble position of certain tRNAs, a critical anticodon loop modification linked to DNA damage survival.

  4. Findings indicate a role for ALKBH8 in urothelial carcinoma cell survival mediated by NOX-1 (show NOX1 Proteins)-dependent ROS (show ROS1 Proteins) signals, further suggesting therapeutic strategies in human bladder cancer by inducing JNK (show MAPK8 Proteins)/p38 (show CRK Proteins)/gammaH2AX (show H2AFX Proteins)-mediated cell death by silencing of ALKBH8.

Mouse (Murine) AlkB, Alkylation Repair Homolog 8 (E. Coli) (ALKBH8) interaction partners

  1. Alkbh8 and tRNA modifications as central regulators of cellular oxidative stress responses in mammalian systems.

  2. The AlkB (show ALKBH Proteins) domain of ALKBH8 specifically hydroxylates mcm(5 (show MCM5 Proteins))U into (S)-mchm(5)U in tRNA-Gly(UCC).

  3. Data show that ALKBH8 is a tRNA methyltransferase required for the final step in the biogenesis of mcm5U.

ALKBH8 Protein Profile

Protein Summary

Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis (By similarity).

Gene names and symbols associated with ALKBH8

  • alkB, alkylation repair homolog 8 (E. coli) (ALKBH8)
  • alkB, alkylation repair homolog 8 (E. coli) (Alkbh8)
  • 4930562C03Rik protein
  • 8030431D03Rik protein
  • 9430088N01Rik protein
  • Abh8 protein

Protein level used designations for ALKBH8

AlkB homologue 8 , S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8 , alkylated DNA repair protein alkB homolog 8 , probable alpha-ketoglutarate-dependent dioxygenase ABH8 , tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8

GENE ID SPECIES
91801 Homo sapiens
489424 Canis lupus familiaris
781788 Bos taurus
67667 Mus musculus
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