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Hydrolyzes only phytoceramide into phytosphingosine and free fatty acid. Additionally we are shipping ACER3 Kits (2) and and many more products for this protein.
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Homozygosity for the p.E33G mutation in the ACER3 gene results in inactivation of ACER3.
The ACER3 deficiency resulted in decreased cell growth and colony formation, elevated apoptosis, and lower AKT (show AKT1 Antibodies) signaling of leukemia cells. This study indicates that ACER3 contributes to AML (show RUNX1 Antibodies) pathogenesis, and suggests that alkaline ceramidase inhibition is an option to treat acute myeloid leukemia (show BCL11A Antibodies).
ACER3 catalyzes the hydrolysis of unsaturated long chain ceramides and dihydroceramides and coordinates with ACER2 (show ACER2 Antibodies) to regulate cell proliferation and survival
Alkaline ceramidase 3 expression has an important role in the innate immune response by regulating the expression of pro-inflammatory cytokines in cells of the innate immune system through C18 (show BBS9 Antibodies):1-ceramide.
Acer3 plays critically protective roles in controlling the homeostasis of various sphingolipids, including ceramides, sphingosine, S1P (show S1PR1 Antibodies), and certain complex sphingolipids in the brain and protects Purkinje cells from premature degeneration.
Hydrolyzes only phytoceramide into phytosphingosine and free fatty acid. Does not have reverse activity (By similarity).
, alkCDase 3
, alkaline CDase 3
, alkaline dihydroceramidase SB89
, alkaline phytoceramidase