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anti-Alkaline Phosphatase, Liver/bone/kidney (ALPL) Antibodies

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). Additionally we are shipping ALPL Kits (39) and ALPL Proteins (19) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ALPL 249 P05186
ALPL 11647 P09242
ALPL 25586 P08289
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Top anti-ALPL Antibodies at antibodies-online.com

Showing 10 out of 162 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB Immunohistochemical analysis of paraffin embedded rat tissue sections ... Western blot analysis of Hela cell tissue lysis using ALPL antibody 0.1 mg Log in to see 6 to 8 Days
$313.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated EIA, FACS, IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
$423.50
Details
Human Mouse Un-conjugated FACS, IHC, ELISA, WB Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green... Figure 2: Flow cytometric analysis of MCF-7 cells using ALPL mouse mAb... 0.1 mg Log in to see 3 to 4 Days
$430.10
Details
Human Rabbit Un-conjugated ELISA, WB   100 μg Log in to see 2 to 3 Days
$275.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of ALPL Antibody (N-term) (ABIN388273) in MCF-7,... 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated EIA, WB   0.2 mg Log in to see 6 to 8 Days
$720.50
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB Western blot analysis of ALPL (arrow) using rabbit polyclonal ALPL Ant... ALPL Antibody (Center) (ABIN388274) western blot analysis in mouse bra... 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB Anti-Alkaline Phosphatase antibody, IHC(P) IHC(P): Rat Small Intestine... All lanes: Anti ALPL () at 0.5ug/ml Lane 1: Human Placenta Tissue Lysa... 100 μg Log in to see 4 to 6 Days
$200.00
Details
Human Rabbit Un-conjugated IHC (p), IHC, WB WB Image Sample (30 ug of whole cell lysate) A: Hela 7.5% SDS PAGE ant... IHC-P Image Immunohistochemical analysis of paraffin-embedded OVCAR3 x... 100 μL Log in to see 2 to 3 Days
$358.60
Details

ALPL Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human , , , ,
, , ,
Mouse (Murine) , , , ,
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Rat (Rattus) , , , ,

Top referenced anti-ALPL Antibodies

  1. Human Polyclonal ALPL Primary Antibody for EIA, WB - ABIN356989 : Panuccio, Cutrupi, Pizzini, Mallamaci, Tripepi, Zoccali: Neuropeptide Y and markers of osteoblast activity in dialysis patients: a cross-sectional study. in American journal of kidney diseases : the official journal of the National Kidney Foundation 2007 (PubMed)
    Show all 3 references for ABIN356989

  2. Human Monoclonal ALPL Primary Antibody for FACS, IHC - ABIN969500 : Kannampuzha, Tupy, Pritzker: Mercaptopyruvate inhibits tissue-nonspecific alkaline phosphatase and calcium pyrophosphate dihydrate crystal dissolution. in The Journal of rheumatology 2009 (PubMed)
    Show all 2 references for ABIN969500

  3. Human Monoclonal ALPL Primary Antibody for EIA, FACS - ABIN1105293 : Kanazawa, Yamaguchi, Yamamoto, Yamauchi, Yano, Sugimoto: Serum osteocalcin/bone-specific alkaline phosphatase ratio is a predictor for the presence of vertebral fractures in men with type 2 diabetes. in Calcified tissue international 2009 (PubMed)
    Show all 2 references for ABIN1105293

  4. Human Polyclonal ALPL Primary Antibody for IHC (p), WB - ABIN1105292 : Fedde, Whyte: Alkaline phosphatase (tissue-nonspecific isoenzyme) is a phosphoethanolamine and pyridoxal-5'-phosphate ectophosphatase: normal and hypophosphatasia fibroblast study. in American journal of human genetics 1990 (PubMed)
    Show all 2 references for ABIN1105292

  5. Human Polyclonal ALPL Primary Antibody for ELISA, WB - ABIN1451976 : Gregory, Barlow, McLay, Kaul, Swarbreck, Dunham, Scott, Howe, Woodfine, Spencer, Jones, Gillson, Searle, Zhou, Kokocinski, McDonald, Evans, Phillips, Atkinson, Cooper, Jones, Hall, Andrews, Lloyd et al.: The DNA sequence and biological annotation of human chromosome 1. ... in Nature 2006 (PubMed)

More Antibodies against ALPL Interaction Partners

Human Alkaline Phosphatase, Liver/bone/kidney (ALPL) interaction partners

  1. Analysis of a series of multiple N-glycan depletion mutants in TNSALP revealed that three N-glycans on N230, N271 and N303 were the minimal requirement for the structure and function of TNSALP and a prerequisite for its stable expression in a cell.

  2. The presence of TNAP increased the dynamics and decreased the ordering of model membranes.

  3. These data confirm that TNAP is co-expressed by dental pulp stromal cells together with other bone marrow stromal cells markers and show that cell density affects TNAP expression levels.

  4. ALP (show ALP Antibodies) quartiles were significantly associated with albuminuria in participants with estimated glomerular filtration rate>120 90-119, 60-89 and <60 mL/min/1.73 Higher ALP (show ALP Antibodies) levels are significantly associated with renal hyperfiltration

  5. during skeletal mineralization, the building Ca2 (show CA2 Antibodies)+ gradient first activates TNAP, but gradually inactivates it at high Ca2 (show CA2 Antibodies)+ concentrations, toward completion of mineralization.

  6. these data demonstrate that TNAP activity is significantly increased in the brain in both the sporadic and familial forms of Alzheimer's Disease (AD) and that TNAP activity is significantly increased in the plasma in AD patients

  7. A non-linear relationship exists between serum levels of ALP (show ALP Antibodies) and phosphate and risk of total mortality from cardiovascular diseases.

  8. ALP (show ALP Antibodies) mRNA binds to and is stabilized by vimentin (show VIM Antibodies).

  9. Elevated AP was associated with the presence of COPD (show ARCN1 Antibodies) and respiratory symptoms (cough, wheezing).

  10. A novel role of alkaline phosphatase in the ERK1 (show MAPK3 Antibodies) and ERK2 (show MAPK1 Antibodies) dephosphorylation in renal cell carcinoma (show MOK Antibodies) cell lines

Mouse (Murine) Alkaline Phosphatase, Liver/bone/kidney (ALPL) interaction partners

  1. TNAP in the vasculature contributes to the pathology of medial vascular calcification and that it is a druggable target.

  2. In cardiac fibroblasts, TNAP expression and activity is induced by sFRP2 (show SFRP2 Antibodies).

  3. p107 (show RBL1 Antibodies) is required for the efficient recruitment of an activating SWI (show SMARCA1 Antibodies)/SNF (show SNRPA Antibodies) chromatin-remodeling complex, an essential event in Alpl induction.

  4. Inhibition of rhBMP-2-induced ALP (show CCL21A Antibodies) activity by intracellular delivery of SMURF1 (show SMURF1 Antibodies) in murine calvarial preosteoblast cells.

  5. Findings demonstrate that Alpl(-/-) mice exhibit a craniofacial skeletal phenotype similar to that seen in infants with HPP (show HPR Antibodies), including true bony craniosynostosis in the context of severely diminished bone mineralization

  6. CD73 and TNAP play interactive roles to metabolize luminally applied 5'-AMP (show TMPRSS5 Antibodies) in the renal vasculature such that inhibition of both is required to inhibit the production of adenosine.

  7. TNAP plays a role in governing the phosphorylation status of phospholamban (show PLN Antibodies) in the sarcoplasmic reticulum.

  8. Taken together, these data indicate that ATF3 (show ATF3 Antibodies) is a novel negative regulator of osteoblast differentiation by specifically suppressing ALP (show CCL21A Antibodies) gene expression in preosteoblasts.

  9. data suggest that the promineralization role of TNAP may be related not only to its accepted pyrophosphatase activity but also to its ability to modify the phosphorylation status of OPN (show SPP1 Antibodies).

  10. mineralization abnormalities of dentin; reduced overall mineralization with decreased matrix vesicle mineralization in the Phospho1 (show PHOSPHO1 Antibodies)(-/-) mice; almost complete absence of matrix vesicles in mice; further reduction in mineralization.

Cow (Bovine) Alkaline Phosphatase, Liver/bone/kidney (ALPL) interaction partners

  1. The peri (show PLIN1 Antibodies)-partum characteristics of serum bone-specific alkaline phosphatase (BAP (show PHB2 Antibodies)) and urinary deoxypyridinoline (DPD (show DPYD Antibodies)) in dairy cattle are reported.

  2. GPI (show GPI Antibodies)-anchored proteins are localized on the outer layer of plasma membranes and clustered in microdomains generally called lipid rafts.

ALPL Antigen Profile

Protein Summary

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization\; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described.

Gene names and symbols associated with ALPL

  • alkaline phosphatase, liver/bone/kidney (alpl) antibody
  • alkaline phosphatase, liver/bone/kidney (ALPL) antibody
  • alkaline phosphatase, intestinal, gene 2 (alpi.2) antibody
  • alkaline phosphatase, liver/bone/kidney (Alpl) antibody
  • Akp-2 antibody
  • Akp2 antibody
  • ALP antibody
  • alpl antibody
  • AP-TNAP antibody
  • APTNAP antibody
  • HOPS antibody
  • iap antibody
  • PHOA antibody
  • TNAP antibody
  • TNS-AP antibody
  • TNSALP antibody

Protein level used designations for ALPL

tissue-nonspecific alkaline phosphatase , alkaline phosphatase, tissue-nonspecific isozyme , tissue non-specific alkaline phosphatase , alkaline phosphatase, liver/bone/kidney , alkaline phosphatase, tissue-nonspecific isozyme-like , alkaline phosphatase liver/bone/kidney isozyme , alkaline phosphomonoesterase , glycerophosphatase , liver/bone/kidney-type alkaline phosphatase , tissue-nonspecific ALP , alkaline phosphatase 2, liver , AP-TNAP , TNSALP , Tissue-nonspecific ALP alkaline phosphatase , alkaline phosphatase tissue non-specific isoform , liver/bone/kidney isozyme

GENE ID SPECIES
380589 Xenopus laevis
403548 Canis lupus familiaris
717809 Macaca mulatta
100144722 Xenopus (Silurana) tropicalis
100401643 Callithrix jacchus
100440770 Pongo abelii
100031702 Monodelphis domestica
456600 Pan troglodytes
100602436 Nomascus leucogenys
249 Homo sapiens
11647 Mus musculus
25586 Rattus norvegicus
280994 Bos taurus
100170147 Sus scrofa
727689 Felis catus
396317 Gallus gallus
101123195 Ovis aries
Selected quality suppliers for anti-ALPL (ALPL) Antibodies
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