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There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). Additionally we are shipping ALPL Kits (39) and ALPL Proteins (19) and many more products for this protein.
Showing 10 out of 162 products:
Human Polyclonal ALPL Primary Antibody for EIA, WB - ABIN356989
Panuccio, Cutrupi, Pizzini, Mallamaci, Tripepi, Zoccali: Neuropeptide Y and markers of osteoblast activity in dialysis patients: a cross-sectional study. in American journal of kidney diseases : the official journal of the National Kidney Foundation 2007
Show all 3 references for ABIN356989
Human Monoclonal ALPL Primary Antibody for FACS, IHC - ABIN969500
Kannampuzha, Tupy, Pritzker: Mercaptopyruvate inhibits tissue-nonspecific alkaline phosphatase and calcium pyrophosphate dihydrate crystal dissolution. in The Journal of rheumatology 2009
Show all 2 references for ABIN969500
Human Monoclonal ALPL Primary Antibody for EIA, FACS - ABIN1105293
Kanazawa, Yamaguchi, Yamamoto, Yamauchi, Yano, Sugimoto: Serum osteocalcin/bone-specific alkaline phosphatase ratio is a predictor for the presence of vertebral fractures in men with type 2 diabetes. in Calcified tissue international 2009
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Human Polyclonal ALPL Primary Antibody for IHC (p), WB - ABIN1105292
Fedde, Whyte: Alkaline phosphatase (tissue-nonspecific isoenzyme) is a phosphoethanolamine and pyridoxal-5'-phosphate ectophosphatase: normal and hypophosphatasia fibroblast study. in American journal of human genetics 1990
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Human Polyclonal ALPL Primary Antibody for ELISA, WB - ABIN1451976
Gregory, Barlow, McLay, Kaul, Swarbreck, Dunham, Scott, Howe, Woodfine, Spencer, Jones, Gillson, Searle, Zhou, Kokocinski, McDonald, Evans, Phillips, Atkinson, Cooper, Jones, Hall, Andrews, Lloyd et al.: The DNA sequence and biological annotation of human chromosome 1. ... in Nature 2006
Analysis of a series of multiple N-glycan depletion mutants in TNSALP revealed that three N-glycans on N230, N271 and N303 were the minimal requirement for the structure and function of TNSALP and a prerequisite for its stable expression in a cell.
The presence of TNAP increased the dynamics and decreased the ordering of model membranes.
These data confirm that TNAP is co-expressed by dental pulp stromal cells together with other bone marrow stromal cells markers and show that cell density affects TNAP expression levels.
ALP (show ALP Antibodies) quartiles were significantly associated with albuminuria in participants with estimated glomerular filtration rate>120 90-119, 60-89 and <60 mL/min/1.73 Higher ALP (show ALP Antibodies) levels are significantly associated with renal hyperfiltration
during skeletal mineralization, the building Ca2 (show CA2 Antibodies)+ gradient first activates TNAP, but gradually inactivates it at high Ca2 (show CA2 Antibodies)+ concentrations, toward completion of mineralization.
these data demonstrate that TNAP activity is significantly increased in the brain in both the sporadic and familial forms of Alzheimer's Disease (AD) and that TNAP activity is significantly increased in the plasma in AD patients
A non-linear relationship exists between serum levels of ALP (show ALP Antibodies) and phosphate and risk of total mortality from cardiovascular diseases.
ALP (show ALP Antibodies) mRNA binds to and is stabilized by vimentin (show VIM Antibodies).
Elevated AP was associated with the presence of COPD (show ARCN1 Antibodies) and respiratory symptoms (cough, wheezing).
A novel role of alkaline phosphatase in the ERK1 (show MAPK3 Antibodies) and ERK2 (show MAPK1 Antibodies) dephosphorylation in renal cell carcinoma (show MOK Antibodies) cell lines
Prevention of lethal murine hypophosphatasia by neonatal ex vivo gene therapy using lentivirally transduced bone marrow cells expressing Akp-2.
TNAP in the vasculature contributes to the pathology of medial vascular calcification and that it is a druggable target.
In cardiac fibroblasts, TNAP expression and activity is induced by sFRP2 (show SFRP2 Antibodies).
p107 (show RBL1 Antibodies) is required for the efficient recruitment of an activating SWI (show SMARCA1 Antibodies)/SNF (show SNRPA Antibodies) chromatin-remodeling complex, an essential event in Alpl induction.
Inhibition of rhBMP-2-induced ALP (show CCL21A Antibodies) activity by intracellular delivery of SMURF1 (show SMURF1 Antibodies) in murine calvarial preosteoblast cells.
Findings demonstrate that Alpl(-/-) mice exhibit a craniofacial skeletal phenotype similar to that seen in infants with HPP (show HPR Antibodies), including true bony craniosynostosis in the context of severely diminished bone mineralization
CD73 and TNAP play interactive roles to metabolize luminally applied 5'-AMP (show TMPRSS5 Antibodies) in the renal vasculature such that inhibition of both is required to inhibit the production of adenosine.
TNAP plays a role in governing the phosphorylation status of phospholamban (show PLN Antibodies) in the sarcoplasmic reticulum.
Taken together, these data indicate that ATF3 (show ATF3 Antibodies) is a novel negative regulator of osteoblast differentiation by specifically suppressing ALP (show CCL21A Antibodies) gene expression in preosteoblasts.
data suggest that the promineralization role of TNAP may be related not only to its accepted pyrophosphatase activity but also to its ability to modify the phosphorylation status of OPN (show SPP1 Antibodies).
The peri (show PLIN1 Antibodies)-partum characteristics of serum bone-specific alkaline phosphatase (BAP (show PHB2 Antibodies)) and urinary deoxypyridinoline (DPD (show DPYD Antibodies)) in dairy cattle are reported.
GPI (show GPI Antibodies)-anchored proteins are localized on the outer layer of plasma membranes and clustered in microdomains generally called lipid rafts.
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization\; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described.
tissue-nonspecific alkaline phosphatase
, alkaline phosphatase, tissue-nonspecific isozyme
, tissue non-specific alkaline phosphatase
, alkaline phosphatase, liver/bone/kidney
, alkaline phosphatase, tissue-nonspecific isozyme-like
, alkaline phosphatase liver/bone/kidney isozyme
, alkaline phosphomonoesterase
, liver/bone/kidney-type alkaline phosphatase
, tissue-nonspecific ALP
, alkaline phosphatase 2, liver
, Tissue-nonspecific ALP alkaline phosphatase
, alkaline phosphatase tissue non-specific isoform
, liver/bone/kidney isozyme