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Alkaline Phosphatase, Liver/bone/kidney Proteins (ALPL)

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). Additionally we are shipping ALPL Antibodies (162) and ALPL Kits (39) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ALPL 249 P05186
ALPL 11647 P09242
ALPL 25586 P08289
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Top ALPL Proteins at antibodies-online.com

Showing 10 out of 19 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Mouse Fc Tag 10 μg Log in to see 16 Days
$250.80
Details
HOST_Human Cells Human His tag 50 μg Log in to see 16 Days
$437.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
$792.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$3,362.33
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,367.83
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,371.50
Details
Yeast Cat His tag   1 mg Log in to see 56 to 66 Days
$3,371.50
Details

ALPL Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Mouse (Murine) ,
,
Rat (Rattus)

Top referenced ALPL Proteins

  1. Mouse (Murine) ALPL Protein expressed in Human Cells - ABIN2008674 : Harris: The human alkaline phosphatases: what we know and what we don't know. in Clinica chimica acta; international journal of clinical chemistry 1990 (PubMed)
    Show all 5 references for ABIN2008674

  2. Human ALPL Protein expressed in Human Cells - ABIN3216384 : Henthorn, Raducha, Fedde, Lafferty, Whyte: Different missense mutations at the tissue-nonspecific alkaline phosphatase gene locus in autosomal recessively inherited forms of mild and severe hypophosphatasia. in Proceedings of the National Academy of Sciences of the United States of America 1992 (PubMed)
    Show all 5 references for ABIN3216384

More Proteins for Alkaline Phosphatase, Liver/bone/kidney (ALPL) Interaction Partners

Human Alkaline Phosphatase, Liver/bone/kidney (ALPL) interaction partners

  1. Analysis of a series of multiple N-glycan depletion mutants in TNSALP revealed that three N-glycans on N230, N271 and N303 were the minimal requirement for the structure and function of TNSALP and a prerequisite for its stable expression in a cell.

  2. The presence of TNAP increased the dynamics and decreased the ordering of model membranes.

  3. These data confirm that TNAP is co-expressed by dental pulp stromal cells together with other bone marrow stromal cells markers and show that cell density affects TNAP expression levels.

  4. ALP (show ALP Proteins) quartiles were significantly associated with albuminuria in participants with estimated glomerular filtration rate>120 90-119, 60-89 and <60 mL/min/1.73 Higher ALP (show ALP Proteins) levels are significantly associated with renal hyperfiltration

  5. during skeletal mineralization, the building Ca2 (show CA2 Proteins)+ gradient first activates TNAP, but gradually inactivates it at high Ca2 (show CA2 Proteins)+ concentrations, toward completion of mineralization.

  6. these data demonstrate that TNAP activity is significantly increased in the brain in both the sporadic and familial forms of Alzheimer's Disease (AD) and that TNAP activity is significantly increased in the plasma in AD patients

  7. A non-linear relationship exists between serum levels of ALP (show ALP Proteins) and phosphate and risk of total mortality from cardiovascular diseases.

  8. ALP (show ALP Proteins) mRNA binds to and is stabilized by vimentin (show VIM Proteins).

  9. Elevated AP was associated with the presence of COPD (show ARCN1 Proteins) and respiratory symptoms (cough, wheezing).

  10. A novel role of alkaline phosphatase in the ERK1 (show MAPK3 Proteins) and ERK2 (show MAPK1 Proteins) dephosphorylation in renal cell carcinoma (show MOK Proteins) cell lines

Mouse (Murine) Alkaline Phosphatase, Liver/bone/kidney (ALPL) interaction partners

  1. Prevention of lethal murine hypophosphatasia by neonatal ex vivo gene therapy using lentivirally transduced bone marrow cells expressing Akp-2.

  2. TNAP in the vasculature contributes to the pathology of medial vascular calcification and that it is a druggable target.

  3. In cardiac fibroblasts, TNAP expression and activity is induced by sFRP2 (show SFRP2 Proteins).

  4. p107 (show RBL1 Proteins) is required for the efficient recruitment of an activating SWI (show SMARCA1 Proteins)/SNF (show SNRPA Proteins) chromatin-remodeling complex, an essential event in Alpl induction.

  5. Inhibition of rhBMP-2-induced ALP (show CCL21A Proteins) activity by intracellular delivery of SMURF1 (show SMURF1 Proteins) in murine calvarial preosteoblast cells.

  6. Findings demonstrate that Alpl(-/-) mice exhibit a craniofacial skeletal phenotype similar to that seen in infants with HPP (show HPR Proteins), including true bony craniosynostosis in the context of severely diminished bone mineralization

  7. CD73 and TNAP play interactive roles to metabolize luminally applied 5'-AMP (show TMPRSS5 Proteins) in the renal vasculature such that inhibition of both is required to inhibit the production of adenosine.

  8. TNAP plays a role in governing the phosphorylation status of phospholamban (show PLN Proteins) in the sarcoplasmic reticulum.

  9. Taken together, these data indicate that ATF3 (show ATF3 Proteins) is a novel negative regulator of osteoblast differentiation by specifically suppressing ALP (show CCL21A Proteins) gene expression in preosteoblasts.

  10. data suggest that the promineralization role of TNAP may be related not only to its accepted pyrophosphatase activity but also to its ability to modify the phosphorylation status of OPN (show SPP1 Proteins).

Cow (Bovine) Alkaline Phosphatase, Liver/bone/kidney (ALPL) interaction partners

  1. The peri (show PLIN1 Proteins)-partum characteristics of serum bone-specific alkaline phosphatase (BAP (show PHB2 Proteins)) and urinary deoxypyridinoline (DPD (show DPYD Proteins)) in dairy cattle are reported.

  2. GPI (show GPI Proteins)-anchored proteins are localized on the outer layer of plasma membranes and clustered in microdomains generally called lipid rafts.

ALPL Protein Profile

Protein Summary

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization\; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described.

Gene names and symbols associated with ALPL

  • alkaline phosphatase, liver/bone/kidney (alpl)
  • alkaline phosphatase, liver/bone/kidney (ALPL)
  • alkaline phosphatase, intestinal, gene 2 (alpi.2)
  • alkaline phosphatase, liver/bone/kidney (Alpl)
  • Akp-2 protein
  • Akp2 protein
  • ALP protein
  • alpl protein
  • AP-TNAP protein
  • APTNAP protein
  • HOPS protein
  • iap protein
  • PHOA protein
  • TNAP protein
  • TNS-AP protein
  • TNSALP protein

Protein level used designations for ALPL

tissue-nonspecific alkaline phosphatase , alkaline phosphatase, tissue-nonspecific isozyme , tissue non-specific alkaline phosphatase , alkaline phosphatase, liver/bone/kidney , alkaline phosphatase, tissue-nonspecific isozyme-like , alkaline phosphatase liver/bone/kidney isozyme , alkaline phosphomonoesterase , glycerophosphatase , liver/bone/kidney-type alkaline phosphatase , tissue-nonspecific ALP , alkaline phosphatase 2, liver , AP-TNAP , TNSALP , Tissue-nonspecific ALP alkaline phosphatase , alkaline phosphatase tissue non-specific isoform , liver/bone/kidney isozyme

GENE ID SPECIES
380589 Xenopus laevis
403548 Canis lupus familiaris
717809 Macaca mulatta
100144722 Xenopus (Silurana) tropicalis
100401643 Callithrix jacchus
100440770 Pongo abelii
100031702 Monodelphis domestica
456600 Pan troglodytes
100602436 Nomascus leucogenys
249 Homo sapiens
11647 Mus musculus
25586 Rattus norvegicus
280994 Bos taurus
100170147 Sus scrofa
727689 Felis catus
396317 Gallus gallus
101123195 Ovis aries
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