Alkaline Phosphatase, Liver/bone/kidney (ALPL) ELISA Kits

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). Additionally we are shipping ALPL Antibodies (222) and ALPL Proteins (16) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
ALPL 249 P05186
ALPL 11647 P09242
ALPL 25586 P08289
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Top ALPL ELISA Kits at antibodies-online.com

Showing 10 out of 40 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Mouse 0.063 ng/mL 0.15-10 ng/mL 96 Tests Log in to see 13 to 16 Days
$576.00
Details
Rat 0.30 ng/mL 0.78-50 ng/mL 96 Tests Log in to see 13 to 16 Days
$608.00
Details
Human 31 pg/mL 78-5000 pg/mL 96 Tests Log in to see 13 to 16 Days
$560.00
Details
Human 1.34 U/L 3.12-200 U/L   96 Tests Log in to see 2 to 3 Days
$658.90
Details
Sheep 3.9 15.6 Typical standard curve 96 Tests Log in to see 13 to 16 Days
$1,026.67
Details
Rat 3.12-200 U/L   96 Tests Log in to see 2 to 3 Days
$658.90
Details
Mouse
3.12-200 U/L   96 Tests Log in to see 2 to 3 Days
$658.90
Details
Rabbit 0.1 U/L 1.0-25 U/L   96 Tests Log in to see 15 to 18 Days
$707.14
Details
Guinea Pig 0.1 U/L 1.0-25 U/L   96 Tests Log in to see 15 to 18 Days
$707.14
Details
Monkey 0.1 ng/mL 0.5-10 ng/mL   96 Tests Log in to see 15 to 18 Days
$707.14
Details

Top referenced ALPL ELISA Kits

  1. Mouse (Murine) ALPL ELISA Kit for Sandwich ELISA - ABIN415660 : Wu, Lin, Liou, Lu, Chen, Fu, Yang: Dextromethorphan inhibits osteoclast differentiation by suppressing RANKL-induced nuclear factor-?B activation. in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2013 (PubMed)
    Show all 5 references for 415660

  2. Rat (Rattus) ALPL ELISA Kit for Sandwich ELISA - ABIN416228 : Gradosova, Zivna, Svejkovska, Palicka, Tichy, Zivny: The role of atorvastatin in bone metabolism in male albino Wistar rats. in Die Pharmazie 2011 (PubMed)
    Show all 4 references for 416228

More ELISA Kits for ALPL Interaction Partners

Human Alkaline Phosphatase, Liver/bone/kidney (ALPL) interaction partners

  1. His ALPL gene mutation came from c.228delG mutation in his mother and c.407G>A compound heterozygous mutation in his father

  2. Both PPARgamma (show PPARG ELISA Kits) gene expression and TNALP activity increased during intracellular lipid accumulation in HepG2 and 3T3-L1 cells. Inhibition of TNALP blocked intracellular lipid accumulation but did not alter expression of the PPARgamma (show PPARG ELISA Kits) gene.

  3. ALPL is a major contributor to the pathogenesis of Prostate cancer progression.

  4. ALPL expression is significantly upregulated in human masticatory mucosa during wound healing

  5. serum ALP (show ALP ELISA Kits) levels were not associated with increased death risk in prevalent HD patients over a 5-year interval.

  6. In conclusion, serum levels of BSP, ALP, ICTP, and PSA increased in patients with bone metastases, and combined detection of all markers could improve the positive-predictive value.

  7. results reveal that the amino acid substitutions at position 426 of TNSALP differentially affect the structure and function of TNSALP, leading to understanding of the molecular and cellular basis of hypophosphatasia.

  8. One-half of adult individuals with unexplained low serum ALP (show ALP ELISA Kits) carried an ALPL mutation. The presence of a mutated allele was associated with tooth loss, slightly lower levels of serum ALP (show ALP ELISA Kits), higher levels of pyridoxal phosphate and phosphoethanolamine, as well as mildly increased serum phosphate.

  9. Dynamic changes of ALP, LDH and PSA during Abiraterone-therapy are associated with best clinical benefit and OS in bone metastatic castration resistant prostate cancer

  10. Analysis of a series of multiple N-glycan depletion mutants in TNSALP revealed that three N-glycans on N230, N271 and N303 were the minimal requirement for the structure and function of TNSALP and a prerequisite for its stable expression in a cell.

Mouse (Murine) Alkaline Phosphatase, Liver/bone/kidney (ALPL) interaction partners

  1. Data, including data from studies using cells from transgenic/knockout mice, suggest that Med1 (show MBD4 ELISA Kits) plays role in enamel formation; Med1 (show MBD4 ELISA Kits) induces Alpl via stimulation of Notch1 (show NOTCH1 ELISA Kits) signaling by forming Notch1 (show NOTCH1 ELISA Kits)-RBP-Jk (show RBPJ ELISA Kits) complex on Alpl promoter. (Med1 (show MBD4 ELISA Kits) = mediator complex subunit 1 (show MED1 ELISA Kits); Alpl = alkaline phosphatase, liver-bone-kidney; Notch1 (show NOTCH1 ELISA Kits) = Notch gene homolog 1 (show NOTCH1 ELISA Kits); RBP-Jk (show RBPJ ELISA Kits) = kappa J region recombining binding protein suppressor of hairless (show RBPJ ELISA Kits))

  2. These analyses revealed that TNAP deficient mice present an increased proliferation of neural precursors, an altered neuronal morphology, and an augmented neuronal activity. We found that these alterations were associated with a partial downregulation of the purinergic P2X7 receptor (P2X7R (show P2RX7 ELISA Kits)).

  3. Despite similar deficiencies in alkaline phosphatase, Alpl(-/-) mice develop craniosynostosis and a brachycephalic/acrocephalic craniofacial shape of variable penetrance.

  4. Prevention of lethal murine hypophosphatasia by neonatal ex vivo gene therapy using lentivirally transduced bone marrow cells expressing Akp-2.

  5. TNAP in the vasculature contributes to the pathology of medial vascular calcification and that it is a druggable target.

  6. In cardiac fibroblasts, TNAP expression and activity is induced by sFRP2 (show SFRP2 ELISA Kits).

  7. p107 (show RBL1 ELISA Kits) is required for the efficient recruitment of an activating SWI (show SMARCA1 ELISA Kits)/SNF (show SNRPA ELISA Kits) chromatin-remodeling complex, an essential event in Alpl induction.

  8. Inhibition of rhBMP-2-induced ALP activity by intracellular delivery of SMURF1 (show SMURF1 ELISA Kits) in murine calvarial preosteoblast cells.

  9. Findings demonstrate that Alpl(-/-) mice exhibit a craniofacial skeletal phenotype similar to that seen in infants with HPP (show HPR ELISA Kits), including true bony craniosynostosis in the context of severely diminished bone mineralization

  10. CD73 and TNAP play interactive roles to metabolize luminally applied 5'-AMP (show TMPRSS5 ELISA Kits) in the renal vasculature such that inhibition of both is required to inhibit the production of adenosine.

Cow (Bovine) Alkaline Phosphatase, Liver/bone/kidney (ALPL) interaction partners

  1. The peri (show PLIN1 ELISA Kits)-partum characteristics of serum bone-specific alkaline phosphatase (BAP (show PHB2 ELISA Kits)) and urinary deoxypyridinoline (DPD (show DPYD ELISA Kits)) in dairy cattle are reported.

  2. GPI (show GPI ELISA Kits)-anchored proteins are localized on the outer layer of plasma membranes and clustered in microdomains generally called lipid rafts.

ALPL Antigen Profile

Antigen Summary

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization\; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described.

Gene names and symbols associated with ALPL

  • alkaline phosphatase, liver/bone/kidney (alpl) antibody
  • alkaline phosphatase, liver/bone/kidney (ALPL) antibody
  • alkaline phosphatase, intestinal, gene 2 (alpi.2) antibody
  • alkaline phosphatase, liver/bone/kidney (Alpl) antibody
  • Akp-2 antibody
  • Akp2 antibody
  • ALP antibody
  • alpl antibody
  • AP-TNAP antibody
  • APTNAP antibody
  • HOPS antibody
  • iap antibody
  • PHOA antibody
  • TNAP antibody
  • TNS-AP antibody
  • TNSALP antibody

Protein level used designations for ALPL

tissue-nonspecific alkaline phosphatase , alkaline phosphatase, tissue-nonspecific isozyme , tissue non-specific alkaline phosphatase , alkaline phosphatase, liver/bone/kidney , alkaline phosphatase, tissue-nonspecific isozyme-like , alkaline phosphatase liver/bone/kidney isozyme , alkaline phosphomonoesterase , glycerophosphatase , liver/bone/kidney-type alkaline phosphatase , tissue-nonspecific ALP , alkaline phosphatase 2, liver , AP-TNAP , TNSALP , Tissue-nonspecific ALP alkaline phosphatase , alkaline phosphatase tissue non-specific isoform , liver/bone/kidney isozyme

GENE ID SPECIES
380589 Xenopus laevis
403548 Canis lupus familiaris
717809 Macaca mulatta
100144722 Xenopus (Silurana) tropicalis
100401643 Callithrix jacchus
100440770 Pongo abelii
100031702 Monodelphis domestica
456600 Pan troglodytes
100602436 Nomascus leucogenys
249 Homo sapiens
11647 Mus musculus
25586 Rattus norvegicus
280994 Bos taurus
100170147 Sus scrofa
727689 Felis catus
396317 Gallus gallus
101123195 Ovis aries
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