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ACCN2 encodes a member of the acid-sensing ion channel (ASIC) family of proteins, which are part of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Additionally we are shipping Amiloride-Sensitive Cation Channel 2, Neuronal Proteins (7) and many more products for this protein.
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Human Polyclonal ACCN2 Primary Antibody for EIA, FACS - ABIN950535
Sherwood, Franke, Conneely, Joyner, Arumugan, Askwith: Identification of protein domains that control proton and calcium sensitivity of ASIC1a. in The Journal of biological chemistry 2009
Show all 3 references for ABIN950535
Mouse (Murine) Monoclonal ACCN2 Primary Antibody for ICC, IF - ABIN2483697
Garcuia-Aunoveros, Derfler, Neville-Golden, Hyman, Corey: BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels. in Proceedings of the National Academy of Sciences of the United States of America 1997
Show all 2 references for ABIN2483697
Mouse (Murine) Monoclonal ACCN2 Primary Antibody for ICC, IF - ABIN2483698
Wemmie, Coryell, Askwith, Lamani, Leonard, Sigmund, Welsh: Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior. in Proceedings of the National Academy of Sciences of the United States of America 2004
Show all 2 references for ABIN2483698
Human Polyclonal ACCN2 Primary Antibody for FACS, IHC (p) - ABIN653218
Kapoor, Bartoszewski, Qadri, Bebok, Bubien, Fuller, Benos: Knockdown of ASIC1 and epithelial sodium channel subunits inhibits glioblastoma whole cell current and cell migration. in The Journal of biological chemistry 2009
Show all 2 references for ABIN653218
Chicken Polyclonal ACCN2 Primary Antibody for WB - ABIN2776229
Hettema, An, Neale, van den Oord, Kendler, Chen: Lack of association between the amiloride-sensitive cation channel 2 (ACCN2) gene and anxiety spectrum disorders. in Psychiatric genetics 2008
Muscles from horses submitted to strenuous exercises produce lactic acid, which may induce variable pain through ACCN (show ACCN1 Antibodies) differential properties; ACCN1 and ACCN3 (show ACCN3 Antibodies) genes have an ubiquitous expression but ACCN1 is more highly expressed in the spinal cord.
The C mutated allele for ACCN2 rs685012 polymorphism was more frequent in panic disorder patients. The ACCN2 TT/ADORA2A (show ADORA2A Antibodies) CT diplotype were more represented in controls. This suggests a role for ACCN2 rs685012 polymorphism in PD development in Caucasian
analysis of a major ASIC1a homotetramer at the surface membrane of the cell expressing functional ASIC1a channel
Our findings support previously reported associations between ASIC1 and panic/anxiety, but not other genes previously associated with anxiety disorders. The
Putative GABAA (show GABRg1 Antibodies) and ASIC1a channels functionally interact with each other, possibly via an inter-molecular association by forming a novel protein complex.
A novel interaction between ASIC1 and integrin-Beta1, mediated by alpha-actinin (show ACTN1 Antibodies) was determined in glioma tumor cells.
ASIC1a opening is accompanied by a distance increase between adjacent thumb and palm domains as well as a movement of Glu (show DCTN1 Antibodies)-235 relative to the knuckle helix.
ASIC1A and ENaCalpha (show SCNN1A Antibodies) form functional heterotrimers acting as ion channels.
This study suggests that ASIC1 may play a role as mediators of inflammatory pain and be involved in the pathogenesis of frozen shoulder.
Genetic variation at ACCN2 appears to be associated with panic disorder and with amygdala phenotypes that have been linked to proneness to anxiety.
Down-regulated expression of ASIC1 RNA and protein was detected in the dysplastic cortex of focal cortical dysplasia patients.
Studies with ASIC1a-ASIC2a (show ACCN1 Antibodies) chimeras showed that swapping the thumb domain between subunits results in faster channel desensitization. Likewise, the covalent modification of Cys (show DNAJC5 Antibodies) residues at selected positions in the beta-ball-thumb interface accelerates the desensitization of the mutant channels.
differential surface trafficking of ASIC1a, ASIC2a (show ACCN1 Antibodies), and ASIC2b, was investigated.
This study demonstrated that asic1 proteins consist of distinct responsible for ion conduction, mechanical force sensing, and transduction to coordinately fulfill their function as sophisticated MS channels.
Acid-sensing ion channel 1a drives AMPA (show GRIA3 Antibodies) receptor plasticity following ischaemia and acidosis in hippocampal CA1 (show CA1 Antibodies) neurons
Deletion of the Asic1a gene significantly prevents RIP1 (show RALBP1 Antibodies) phosphorylation and brain damage, suggesting ASIC1a-mediated RIP1 (show RALBP1 Antibodies) activation has an important role in ischemic neuronal injury.
Study suggests that ASIC1a activity facilitates NMDAR (show GRIN1 Antibodies) function and exacerbates NMDAR (show GRIN1 Antibodies)-mediated neuronal death in pathological conditions
The data of this study suggest that ASIC1a may be a mediator of SCA1 (show ATXN1 Antibodies) pathogenesis and targeting ASIC1a could be a novel approach to treat SCA1 (show ATXN1 Antibodies).
ASIC1A inhibits neuronal plasticity underlying addiction-related behavior; disrupting ASIC1A in the mouse nucleus accumbens increases cocaine-conditioned place preference.
We conclude that this optogenetic method offers a minimally invasive approach that enables examining the biological consequences of ASIC1a currents in any structure of the CNS and in the modulation of animal behaviors.
Data suggest that mitochondrial ASIC1a may serve as an important regulator of MPT pores, which contributes to oxidative neuronal cell death.
Data from models of hyperactive bladder suggest that ASIC1 is involved in ATP release from bladder mucosa stimulated by stretch/acid; studies include evidence ASIC isoforms are expressed in lateral wall, dome, trigone, and neck of detrusor/mucosa.
This gene encodes a member of the acid-sensing ion channel (ASIC) family of proteins, which are part of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Members of the ASIC family are sensitive to amiloride and function in neurotransmission. The encoded proteins function in learning, pain transduction, touch sensation, and development of memory and fear. Alternatively spliced transcript variants have been described.
amiloride-sensitive cation channel 2, neuronal
, amiloride-sensitive cation channel 1, neuronal
, Amiloride-sensitive cation channel 2, neuronal
, acid-sensing ion channel 1
, brain sodium channel 2
, proton gated cation channel ASIC1
, Cation channel, amiloride-sensitive, neuronal, 2
, acid-sensing ion channel 1a protein
, acid sensing ion channel
, degenerin 2