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ACCN2 encodes a member of the acid-sensing ion channel (ASIC) family of proteins, which are part of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Additionally we are shipping Amiloride-Sensitive Cation Channel 2, Neuronal Antibodies (120) and Amiloride-Sensitive Cation Channel 2, Neuronal Proteins (7) and many more products for this protein.
Muscles from horses submitted to strenuous exercises produce lactic acid, which may induce variable pain through ACCN (show ACCN1 ELISA Kits) differential properties; ACCN1 and ACCN3 (show ACCN3 ELISA Kits) genes have an ubiquitous expression but ACCN1 is more highly expressed in the spinal cord.
ASIC1 contributes to breast cancer pathogenesis in response to acidic tumor microenvironments
The results show that acid-sensing ion channel 1, acid-sensing ion channel 2 (show ACCN1 ELISA Kits), and acid-sensing ion channel 3 (show ACCN3 ELISA Kits) are expressed in A549 cells at the messenger RNA and protein levels, and acid-sensing ion channel-like currents were elicited by extracellular acid stimuli.
Data show that acid sensing ion channel 1a (ASIC1a) mediated calcium influx, which resulted in the activation of PI3K (show PIK3CA ELISA Kits)/AKT (show AKT1 ELISA Kits) signaling and increased drug resistance, suggesting that ASIC1a/Ca(2 (show CA2 ELISA Kits)+)/PI3K (show PIK3CA ELISA Kits)/AKT (show AKT1 ELISA Kits) signaling represents a pathway that regulates drug resistance, thus offering a potential target for chemotherapy of hepatocellular carcinoma (HCC (show FAM126A ELISA Kits)).
Downregulation of ASIC1 inhibits gastric cancer growth via decreasing autophagy, therefore this strongly suggests a therapeutic role for ASIC1 in gastric cancer.
The C mutated allele for ACCN2 rs685012 polymorphism was more frequent in panic disorder patients. The ACCN2 TT/ADORA2A (show ADORA2A ELISA Kits) CT diplotype were more represented in controls. This suggests a role for ACCN2 rs685012 polymorphism in PD development in Caucasian
analysis of a major ASIC1a homotetramer at the surface membrane of the cell expressing functional ASIC1a channel
Our findings support previously reported associations between ASIC1 and panic/anxiety, but not other genes previously associated with anxiety disorders. The
Putative GABAA (show GABRg1 ELISA Kits) and ASIC1a channels functionally interact with each other, possibly via an inter-molecular association by forming a novel protein complex.
A novel interaction between ASIC1 and integrin-Beta1, mediated by alpha-actinin (show ACTN1 ELISA Kits) was determined in glioma tumor cells.
ASIC1a opening is accompanied by a distance increase between adjacent thumb and palm domains as well as a movement of Glu (show DCTN1 ELISA Kits)-235 relative to the knuckle helix.
ASIC1a Deficient Mice Show Unaltered Neurodegeneration in the Subacute MPTP (show PTPN2 ELISA Kits) Model of Parkinson Disease
The manuscript demonstrates that postsynaptic neurons of the medial nucleus of the trapezoid body at the mouse calyx of Held synapse express functional homomeric Acid-sensing ion channel-1a (ASIC-1as) that can be activated by protons (coreleased with neurotransmitter from acidified synaptic vesicles). These ASIC-1as contribute to the generation of postsynaptic currents and, more relevant, to calcium influx, which could be
nonselective cation channels ( channels consist of at least one alpha-ENaC (show SCNN1A ELISA Kits) and one or more acid-sensing ion channel 1a (ASIC1a) proteins.
ASIC1a is an important mediator of AHR (show AHR ELISA Kits).
Ca(2 (show CA2 ELISA Kits)+) influx through ASIC1 mediates chronic hypoxia and ET-1 (show EDN1 ELISA Kits)-induced NFATc3 (show NFATC3 ELISA Kits) nuclear import and 2) the scaffolding protein PICK1 (show PICK1 ELISA Kits) is necessary for NFATc3 (show NFATC3 ELISA Kits) nuclear import.
This study provides evidence that ASIC1a is involved in group I metabotropic glutamate (show GRIN1 ELISA Kits) (mGlu) receptor-induced increase in action potential firing.
the potentiation of ASICs by quinine depends on the presence of the ASIC1a, ASIC2a (show ACCN1 ELISA Kits) subunits, but not ASIC1b, ASIC3 (show ACCN3 ELISA Kits) subunits. Furthermore, we have determined the amino acids in ASIC1a that are involved in the modulation of ASICs by pHi.
Studies with ASIC1a-ASIC2a (show ACCN1 ELISA Kits) chimeras showed that swapping the thumb domain between subunits results in faster channel desensitization. Likewise, the covalent modification of Cys (show DNAJC5 ELISA Kits) residues at selected positions in the beta-ball-thumb interface accelerates the desensitization of the mutant channels.
differential surface trafficking of ASIC1a, ASIC2a (show ACCN1 ELISA Kits), and ASIC2b, was investigated.
This study demonstrated that asic1 proteins consist of distinct responsible for ion conduction, mechanical force sensing, and transduction to coordinately fulfill their function as sophisticated MS channels.
Data from models of hyperactive bladder suggest that ASIC1 is involved in ATP release from bladder mucosa stimulated by stretch/acid; studies include evidence ASIC isoforms are expressed in lateral wall, dome, trigone, and neck of detrusor/mucosa.
This gene encodes a member of the acid-sensing ion channel (ASIC) family of proteins, which are part of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Members of the ASIC family are sensitive to amiloride and function in neurotransmission. The encoded proteins function in learning, pain transduction, touch sensation, and development of memory and fear. Alternatively spliced transcript variants have been described.
amiloride-sensitive cation channel 2, neuronal
, amiloride-sensitive cation channel 1, neuronal
, Amiloride-sensitive cation channel 2, neuronal
, acid-sensing ion channel 1
, brain sodium channel 2
, proton gated cation channel ASIC1
, Cation channel, amiloride-sensitive, neuronal, 2
, acid-sensing ion channel 1a protein
, acid sensing ion channel
, degenerin 2