anti-Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) Antibodies

ACCN2 encodes a member of the acid-sensing ion channel (ASIC) family of proteins, which are part of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Additionally we are shipping Amiloride-Sensitive Cation Channel 2, Neuronal Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ACCN2 79123 P55926
ACCN2 41 P78348
ACCN2 11419 Q6NXK8
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Top anti-Amiloride-Sensitive Cation Channel 2, Neuronal Antibodies at antibodies-online.com

Showing 10 out of 119 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-ACCN2 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:12500<br><b>Positive Control: </b>HT1080 cell lysate Host: Rabbit <br /> Target Name: ASIC1 <br /> Sample Tissue: MCF7 cell lysates <br /> Antibody Dilution: 1.0 µg/mL 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB Host: Rabbit Target Name: ASIC1 Sample Tissue: Human MCF7 Antibody Dilution: 1.0ug/ml Host: Rabbit Target Name: ASIC1 Sample Type: 721_B Whole Cell lysates Antibody Dilution: 1.0ug/ml 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of ACCN2 Antibody (C-term) (ABIN653218) in CEM cell line lysates (35 µg/lane). ACCN2 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human brain tissue reacted with ACCN2 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, FACS, IHC (p), WB ACCN2 Antibody (C-term) flow cytometric analysis of CEM cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Formalin-fixed and paraffin-embedded human brain tissue reacted with ACCN2 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Mouse Goat Un-conjugated ELISA, WB Western Blot: ACCN2 Antibody [NBP2-42507] - Analysis of Mouse fetal Brain lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 7 to 9 Days
$408.19
Details
Mouse Mouse HRP ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-ASIC1 Monoclonal Antibody, Clone S271-44 . Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-ASIC1 Monoclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Cell Membrane, Nucleus. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) ASIC1 Antibody (D) Composite. Western Blot analysis of Rat brain lysates showing detection of ASIC1 protein using Mouse Anti-ASIC1 Monoclonal Antibody, Clone S271-44 . Primary Antibody: Mouse Anti-ASIC1 Monoclonal Antibody  at 1:100, 1:250, 1:500, and 1:1000. 100 μg Log in to see 2 to 3 Days
$422.40
Details
Mouse Mouse FITC ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-ASIC1 Monoclonal Antibody, Clone S271-44 . Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-ASIC1 Monoclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Cell Membrane, Nucleus. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) ASIC1 Antibody (D) Composite. Western Blot analysis of Rat brain lysates showing detection of ASIC1 protein using Mouse Anti-ASIC1 Monoclonal Antibody, Clone S271-44 . Primary Antibody: Mouse Anti-ASIC1 Monoclonal Antibody  at 1:100, 1:250, 1:500, and 1:1000. 100 μg Log in to see 2 to 3 Days
$426.80
Details
Mouse Mouse Alkaline Phosphatase (AP) ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-ASIC1 Monoclonal Antibody, Clone S271-44 . Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-ASIC1 Monoclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Cell Membrane, Nucleus. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) ASIC1 Antibody (D) Composite. Western Blot analysis of Rat brain lysates showing detection of ASIC1 protein using Mouse Anti-ASIC1 Monoclonal Antibody, Clone S271-44 . Primary Antibody: Mouse Anti-ASIC1 Monoclonal Antibody  at 1:100, 1:250, 1:500, and 1:1000. 100 μg Log in to see 2 to 3 Days
$429.00
Details
Mouse Mouse Biotin ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-ASIC1 Monoclonal Antibody, Clone S271-44 . Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-ASIC1 Monoclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Cell Membrane, Nucleus. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) ASIC1 Antibody (D) Composite. Western Blot analysis of Rat brain lysates showing detection of ASIC1 protein using Mouse Anti-ASIC1 Monoclonal Antibody, Clone S271-44 . Primary Antibody: Mouse Anti-ASIC1 Monoclonal Antibody  at 1:100, 1:250, 1:500, and 1:1000. 100 μg Log in to see 2 to 3 Days
$431.20
Details
Mouse Mouse PE ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-ASIC1 Monoclonal Antibody, Clone S271-44 . Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-ASIC1 Monoclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Cell Membrane, Nucleus. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) ASIC1 Antibody (D) Composite. Western Blot analysis of Rat brain lysates showing detection of ASIC1 protein using Mouse Anti-ASIC1 Monoclonal Antibody, Clone S271-44 . Primary Antibody: Mouse Anti-ASIC1 Monoclonal Antibody  at 1:100, 1:250, 1:500, and 1:1000. 100 μg Log in to see 2 to 3 Days
$432.30
Details

ACCN2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Amiloride-Sensitive Cation Channel 2, Neuronal Antibodies

  1. Mammalian Monoclonal ACCN2 Primary Antibody for ISt, IHC - ABIN1304544 : Lin, Sun, Chen: Genetic exploration of the role of acid-sensing ion channels. in Neuropharmacology 2015 (PubMed)
    Show all 3 Pubmed References

  2. Mouse (Murine) Polyclonal ACCN2 Primary Antibody for ELISA, WB - ABIN4277576 : Hoagland, Sherwood, Lee, Walker, Askwith: Identification of a calcium permeable human acid-sensing ion channel 1 transcript variant. in The Journal of biological chemistry 2010 (PubMed)

More Antibodies against Amiloride-Sensitive Cation Channel 2, Neuronal Interaction Partners

Horse (Equine) Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) interaction partners

  1. Muscles from horses submitted to strenuous exercises produce lactic acid, which may induce variable pain through ACCN (show ACCN1 Antibodies) differential properties; ACCN1 and ACCN3 (show ACCN3 Antibodies) genes have an ubiquitous expression but ACCN1 is more highly expressed in the spinal cord.

Human Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) interaction partners

  1. ASIC1 contributes to breast cancer pathogenesis in response to acidic tumor microenvironments

  2. The results show that acid-sensing ion channel 1, acid-sensing ion channel 2 (show ACCN1 Antibodies), and acid-sensing ion channel 3 (show ACCN3 Antibodies) are expressed in A549 cells at the messenger RNA and protein levels, and acid-sensing ion channel-like currents were elicited by extracellular acid stimuli.

  3. Data show that acid sensing ion channel 1a (ASIC1a) mediated calcium influx, which resulted in the activation of PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) signaling and increased drug resistance, suggesting that ASIC1a/Ca(2 (show CA2 Antibodies)+)/PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) signaling represents a pathway that regulates drug resistance, thus offering a potential target for chemotherapy of hepatocellular carcinoma (HCC (show FAM126A Antibodies)).

  4. Downregulation of ASIC1 inhibits gastric cancer growth via decreasing autophagy, therefore this strongly suggests a therapeutic role for ASIC1 in gastric cancer.

  5. The C mutated allele for ACCN2 rs685012 polymorphism was more frequent in panic disorder patients. The ACCN2 TT/ADORA2A (show ADORA2A Antibodies) CT diplotype were more represented in controls. This suggests a role for ACCN2 rs685012 polymorphism in PD development in Caucasian

  6. analysis of a major ASIC1a homotetramer at the surface membrane of the cell expressing functional ASIC1a channel

  7. Our findings support previously reported associations between ASIC1 and panic/anxiety, but not other genes previously associated with anxiety disorders. The

  8. Putative GABAA (show GABRg1 Antibodies) and ASIC1a channels functionally interact with each other, possibly via an inter-molecular association by forming a novel protein complex.

  9. A novel interaction between ASIC1 and integrin-Beta1, mediated by alpha-actinin (show ACTN1 Antibodies) was determined in glioma tumor cells.

  10. ASIC1a opening is accompanied by a distance increase between adjacent thumb and palm domains as well as a movement of Glu (show DCTN1 Antibodies)-235 relative to the knuckle helix.

Mouse (Murine) Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) interaction partners

  1. ASIC1a Deficient Mice Show Unaltered Neurodegeneration in the Subacute MPTP (show PTPN2 Antibodies) Model of Parkinson Disease

  2. The manuscript demonstrates that postsynaptic neurons of the medial nucleus of the trapezoid body at the mouse calyx of Held synapse express functional homomeric Acid-sensing ion channel-1a (ASIC-1as) that can be activated by protons (coreleased with neurotransmitter from acidified synaptic vesicles). These ASIC-1as contribute to the generation of postsynaptic currents and, more relevant, to calcium influx, which could be

  3. nonselective cation channels ( channels consist of at least one alpha-ENaC (show SCNN1A Antibodies) and one or more acid-sensing ion channel 1a (ASIC1a) proteins.

  4. ASIC1a is an important mediator of AHR (show AHR Antibodies).

  5. Ca(2 (show CA2 Antibodies)+) influx through ASIC1 mediates chronic hypoxia and ET-1 (show EDN1 Antibodies)-induced NFATc3 (show NFATC3 Antibodies) nuclear import and 2) the scaffolding protein PICK1 (show PICK1 Antibodies) is necessary for NFATc3 (show NFATC3 Antibodies) nuclear import.

  6. This study provides evidence that ASIC1a is involved in group I metabotropic glutamate (show GRIN1 Antibodies) (mGlu) receptor-induced increase in action potential firing.

  7. the potentiation of ASICs by quinine depends on the presence of the ASIC1a, ASIC2a (show ACCN1 Antibodies) subunits, but not ASIC1b, ASIC3 (show ACCN3 Antibodies) subunits. Furthermore, we have determined the amino acids in ASIC1a that are involved in the modulation of ASICs by pHi.

  8. Studies with ASIC1a-ASIC2a (show ACCN1 Antibodies) chimeras showed that swapping the thumb domain between subunits results in faster channel desensitization. Likewise, the covalent modification of Cys (show DNAJC5 Antibodies) residues at selected positions in the beta-ball-thumb interface accelerates the desensitization of the mutant channels.

  9. differential surface trafficking of ASIC1a, ASIC2a (show ACCN1 Antibodies), and ASIC2b, was investigated.

  10. This study demonstrated that asic1 proteins consist of distinct responsible for ion conduction, mechanical force sensing, and transduction to coordinately fulfill their function as sophisticated MS channels.

Pig (Porcine) Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) interaction partners

  1. Data from models of hyperactive bladder suggest that ASIC1 is involved in ATP release from bladder mucosa stimulated by stretch/acid; studies include evidence ASIC isoforms are expressed in lateral wall, dome, trigone, and neck of detrusor/mucosa.

Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) Antigen Profile

Protein Summary

This gene encodes a member of the acid-sensing ion channel (ASIC) family of proteins, which are part of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Members of the ASIC family are sensitive to amiloride and function in neurotransmission. The encoded proteins function in learning, pain transduction, touch sensation, and development of memory and fear. Alternatively spliced transcript variants have been described.

Gene names and symbols associated with ACCN2

  • amiloride-sensitive cation channel 2, neuronal (ACCN2) antibody
  • acid-sensing (proton-gated) ion channel 2 (ACCN1) antibody
  • Amiloride-sensitive cation channel 2, neuronal (accn2) antibody
  • acid-sensing (proton-gated) ion channel 1 (Asic1) antibody
  • acid-sensing (proton-gated) ion channel 1 (ASIC1) antibody
  • acid-sensing (proton-gated) ion channel 1 (ACCN2) antibody
  • ACCN2 antibody
  • AI843610 antibody
  • ASIC antibody
  • ASIC1 antibody
  • ASIC1a antibody
  • B530003N02Rik antibody
  • BNaC2 antibody

Protein level used designations for ACCN2

amiloride-sensitive cation channel 2, neuronal , amiloride-sensitive cation channel 1, neuronal , Amiloride-sensitive cation channel 2, neuronal , BNaC2 , acid-sensing ion channel 1 , brain sodium channel 2 , proton gated cation channel ASIC1 , Cation channel, amiloride-sensitive, neuronal, 2 , acid-sensing ion channel 1a protein , acid sensing ion channel , degenerin 2

GENE ID SPECIES
451888 Pan troglodytes
100058355 Equus caballus
100194955 Salmo salar
100355858 Oryctolagus cuniculus
713320 Macaca mulatta
79123 Rattus norvegicus
41 Homo sapiens
11419 Mus musculus
100517467 Sus scrofa
426883 Gallus gallus
477612 Canis lupus familiaris
538244 Bos taurus
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