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ACCN2 encodes a member of the acid-sensing ion channel (ASIC) family of proteins, which are part of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Additionally we are shipping Amiloride-Sensitive Cation Channel 2, Neuronal Proteins (7) and many more products for this protein.
Showing 10 out of 104 products:
Human Polyclonal ACCN2 Primary Antibody for EIA, FACS - ABIN950535
Sherwood, Franke, Conneely, Joyner, Arumugan, Askwith: Identification of protein domains that control proton and calcium sensitivity of ASIC1a. in The Journal of biological chemistry 2009
Show all 3 references for ABIN950535
Mouse (Murine) Monoclonal ACCN2 Primary Antibody for ICC, IF - ABIN2483692
Garcuia-Aunoveros, Derfler, Neville-Golden, Hyman, Corey: BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels. in Proceedings of the National Academy of Sciences of the United States of America 1997
Show all 2 references for ABIN2483692
Mouse (Murine) Monoclonal ACCN2 Primary Antibody for ICC, IF - ABIN2483697
Wemmie, Coryell, Askwith, Lamani, Leonard, Sigmund, Welsh: Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior. in Proceedings of the National Academy of Sciences of the United States of America 2004
Show all 2 references for ABIN2483697
Human Polyclonal ACCN2 Primary Antibody for FACS, IHC (p) - ABIN653218
Kapoor, Bartoszewski, Qadri, Bebok, Bubien, Fuller, Benos: Knockdown of ASIC1 and epithelial sodium channel subunits inhibits glioblastoma whole cell current and cell migration. in The Journal of biological chemistry 2009
Show all 2 references for ABIN653218
Cow (Bovine) Polyclonal ACCN2 Primary Antibody for WB - ABIN2776229
Hettema, An, Neale, van den Oord, Kendler, Chen: Lack of association between the amiloride-sensitive cation channel 2 (ACCN2) gene and anxiety spectrum disorders. in Psychiatric genetics 2008
Mouse (Murine) Polyclonal ACCN2 Primary Antibody for ELISA, WB - ABIN4277576
Hoagland, Sherwood, Lee, Walker, Askwith: Identification of a calcium permeable human acid-sensing ion channel 1 transcript variant. in The Journal of biological chemistry 2010
Muscles from horses submitted to strenuous exercises produce lactic acid, which may induce variable pain through ACCN (show ACCN1 Antibodies) differential properties; ACCN1 and ACCN3 (show ACCN3 Antibodies) genes have an ubiquitous expression but ACCN1 is more highly expressed in the spinal cord.
The results show that acid-sensing ion channel 1, acid-sensing ion channel 2 (show ACCN1 Antibodies), and acid-sensing ion channel 3 (show ACCN3 Antibodies) are expressed in A549 cells at the messenger RNA and protein levels, and acid-sensing ion channel-like currents were elicited by extracellular acid stimuli.
Data show that acid sensing ion channel 1a (ASIC1a) mediated calcium influx, which resulted in the activation of PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) signaling and increased drug resistance, suggesting that ASIC1a/Ca(2 (show CA2 Antibodies)+)/PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) signaling represents a pathway that regulates drug resistance, thus offering a potential target for chemotherapy of hepatocellular carcinoma (HCC (show FAM126A Antibodies)).
Downregulation of ASIC1 inhibits gastric cancer growth via decreasing autophagy, therefore this strongly suggests a therapeutic role for ASIC1 in gastric cancer.
The C mutated allele for ACCN2 rs685012 polymorphism was more frequent in panic disorder patients. The ACCN2 TT/ADORA2A (show ADORA2A Antibodies) CT diplotype were more represented in controls. This suggests a role for ACCN2 rs685012 polymorphism in PD development in Caucasian
analysis of a major ASIC1a homotetramer at the surface membrane of the cell expressing functional ASIC1a channel
Our findings support previously reported associations between ASIC1 and panic/anxiety, but not other genes previously associated with anxiety disorders. The
Putative GABAA (show GABRg1 Antibodies) and ASIC1a channels functionally interact with each other, possibly via an inter-molecular association by forming a novel protein complex.
A novel interaction between ASIC1 and integrin-Beta1, mediated by alpha-actinin (show ACTN1 Antibodies) was determined in glioma tumor cells.
ASIC1a opening is accompanied by a distance increase between adjacent thumb and palm domains as well as a movement of Glu (show DCTN1 Antibodies)-235 relative to the knuckle helix.
ASIC1A and ENaCalpha (show SCNN1A Antibodies) form functional heterotrimers acting as ion channels.
Ca(2 (show CA2 Antibodies)+) influx through ASIC1 mediates chronic hypoxia and ET-1 (show EDN1 Antibodies)-induced NFATc3 (show NFATC3 Antibodies) nuclear import and 2) the scaffolding protein PICK1 (show PICK1 Antibodies) is necessary for NFATc3 (show NFATC3 Antibodies) nuclear import.
This study provides evidence that ASIC1a is involved in group I metabotropic glutamate (show GRIN1 Antibodies) (mGlu) receptor-induced increase in action potential firing.
the potentiation of ASICs by quinine depends on the presence of the ASIC1a, ASIC2a (show ACCN1 Antibodies) subunits, but not ASIC1b, ASIC3 (show ACCN3 Antibodies) subunits. Furthermore, we have determined the amino acids in ASIC1a that are involved in the modulation of ASICs by pHi.
Studies with ASIC1a-ASIC2a (show ACCN1 Antibodies) chimeras showed that swapping the thumb domain between subunits results in faster channel desensitization. Likewise, the covalent modification of Cys (show DNAJC5 Antibodies) residues at selected positions in the beta-ball-thumb interface accelerates the desensitization of the mutant channels.
differential surface trafficking of ASIC1a, ASIC2a (show ACCN1 Antibodies), and ASIC2b, was investigated.
This study demonstrated that asic1 proteins consist of distinct responsible for ion conduction, mechanical force sensing, and transduction to coordinately fulfill their function as sophisticated MS channels.
Acid-sensing ion channel 1a drives AMPA (show GRIA3 Antibodies) receptor plasticity following ischaemia and acidosis in hippocampal CA1 (show CA1 Antibodies) neurons
Deletion of the Asic1a gene significantly prevents RIP1 (show RALBP1 Antibodies) phosphorylation and brain damage, suggesting ASIC1a-mediated RIP1 (show RALBP1 Antibodies) activation has an important role in ischemic neuronal injury.
Study suggests that ASIC1a activity facilitates NMDAR (show GRIN1 Antibodies) function and exacerbates NMDAR (show GRIN1 Antibodies)-mediated neuronal death in pathological conditions
The data of this study suggest that ASIC1a may be a mediator of SCA1 (show ATXN1 Antibodies) pathogenesis and targeting ASIC1a could be a novel approach to treat SCA1 (show ATXN1 Antibodies).
Data from models of hyperactive bladder suggest that ASIC1 is involved in ATP release from bladder mucosa stimulated by stretch/acid; studies include evidence ASIC isoforms are expressed in lateral wall, dome, trigone, and neck of detrusor/mucosa.
This gene encodes a member of the acid-sensing ion channel (ASIC) family of proteins, which are part of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Members of the ASIC family are sensitive to amiloride and function in neurotransmission. The encoded proteins function in learning, pain transduction, touch sensation, and development of memory and fear. Alternatively spliced transcript variants have been described.
amiloride-sensitive cation channel 2, neuronal
, amiloride-sensitive cation channel 1, neuronal
, Amiloride-sensitive cation channel 2, neuronal
, acid-sensing ion channel 1
, brain sodium channel 2
, proton gated cation channel ASIC1
, Cation channel, amiloride-sensitive, neuronal, 2
, acid-sensing ion channel 1a protein
, acid sensing ion channel
, degenerin 2