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The protein encoded by AIMP1 is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. Additionally we are shipping AIMP1 Proteins (30) and AIMP1 Kits (19) and many more products for this protein.
Showing 10 out of 93 products:
Human Monoclonal AIMP1 Primary Antibody for WB - ABIN396143
Kim, Han, Kim: Toll-like receptor 4-mediated c-Jun N-terminal kinase activation induces gp96 cell surface expression via AIMP1 phosphorylation. in Biochemical and biophysical research communications 2010
Show all 5 references for ABIN396143
Human Monoclonal AIMP1 Primary Antibody for IF - ABIN396832
Park, Park, Jeong, Cho, Lee, Kang, Kim, Park: Autoantibodies against aminoacyl-tRNA synthetase: novel diagnostic marker for type 1 diabetes mellitus. in Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2010
Show all 5 references for ABIN396832
Human Monoclonal AIMP1 Primary Antibody for EIA, FACS - ABIN1108957
Mueller, Schluesener, Conrad, Meyermann, Schwab: Spinal cord injury induces lesional expression of the proinflammatory and antiangiogenic cytokine EMAP II. in Journal of neurotrauma 2003
Show all 2 references for ABIN1108957
Human Monoclonal AIMP1 Primary Antibody for EIA, IHC (fro) - ABIN112011
Schluesener, Seid, Meyermann: Effects of autoantigen and dexamethasone treatment on expression of endothelial-monocyte activating polypeptide II and allograft-inflammatory factor-1 by activated macrophages and microglial cells in lesions of experimental autoimmune encephalomyelitis, n in Acta neuropathologica 1999
Show all 2 references for ABIN112011
Human Polyclonal AIMP1 Primary Antibody for EIA, WB - ABIN453182
Awasthi, Schwarz, Verma, Cappiello, Schwarz: Endothelial monocyte activating polypeptide II interferes with VEGF-induced proangiogenic signaling. in Laboratory investigation; a journal of technical methods and pathology 2008
Show all 2 references for ABIN453182
Cow (Bovine) Polyclonal AIMP1 Primary Antibody for WB - ABIN2778912
Tandle, Mazzanti, Alexander, Roberts, Libutti: Endothelial monocyte activating polypeptide-II induced gene expression changes in endothelial cells. in Cytokine 2005
Cow (Bovine) Polyclonal AIMP1 Primary Antibody for WB - ABIN2778913
Bottoni, Vignali, Piccin, Tagliati, Luchin, Zatelli, Uberti: Proteasomes and RARS modulate AIMP1/EMAP II secretion in human cancer cell lines. in Journal of cellular physiology 2007
p43 induces both the mRNA and protein expression of IP-10 (show CXCL10 Antibodies).
Data indicate that AIMP1 downregulation using siRNA is a novel tool to restore TGF-beta (show TGFB1 Antibodies) signaling and thereby increases the chondrogenic potential of dedifferentiated/degenerated chondrocytes.
two homozygous missense variants, p.(Gly299Arg) and p.(Val176Gly), in the gene AIMP1 that co-segregated with the phenotype, are reported.
AIMp1 promotes the proliferation and migration of fibroblasts/endothelial cells and importantly, pro-inflammatory gene expression in monocytes/macrophages and dendritic cells.
AIMP1 appears to function as a novel inhibitor of PPARgamma (show PPARG Antibodies) that regulates adipocyte differentiation by preventing the transcriptional activation of PPARgamma (show PPARG Antibodies).
Data indicate that HCV E2 glycoprotein interacts with cellular AIMP1/p43 protein and promotes cell surface expression of membrane glycoproteins gp96 (show HSP90B1 Antibodies) and transforming growth factor beta TGF-beta signaling.
Data indicate that the N terminus of Pro-EMAP II binds to its C terminus, arginyl-tRNA synthetase (show RARS Antibodies), and the neurofilament light subunit.
EMAP2 (show EML2 Antibodies) is a multifunctional polypeptide with proinflammatory and antiangiogenic activity. (Review)
interactions between the N-terminal domains of ArgRS (show RARS Antibodies) and AIMP1 are important for the catalytic and noncatalytic activities of ArgRS (show RARS Antibodies) and for the assembly of the higher-order MSC (show MSC Antibodies) protein complex with ArgRS (show RARS Antibodies)-GlnRS (show QARS Antibodies)-AIMP1
AIMP1 peptide promotes the proliferation of BMMSCs by activating the beta-catenin (show CTNNB1 Antibodies)/TCF (show HNF4A Antibodies) complex via FGFR2 (show FGFR2 Antibodies)-mediated activation of Akt (show AKT1 Antibodies), which leads to an increase in mesenchymal stem cells in peripheral blood.
findings indicate that Aimp1 might act as an important regulator to remodel the uterine endometrium and its expression might be regulated by estrogen during the estrous cycle.
our results show that AIMP1 acts as a novel B cell-activating factor (show TNFSF13B Antibodies)
The data showed that AIMP1 is a negative regulator of TH2 immune responses, mainly via CD4 (show CD4 Antibodies)+ T cells.
In dendritic cells, AIMP1 enhances toll-like receptor 2 (TLR2 (show TLR2 Antibodies))-mediated immune responses via the up-regulation of TLR2 (show TLR2 Antibodies) expression.
Lung-specific overexpression of EMAPII in mice caused simplification of alveolar structures, apoptosis, & macrophage accumulation. Smoking-induced upregulation involved an apoptosis-dependent feed-forward loop.
AIMP1 plays a glucagon (show GCG Antibodies)-like role in glucose homeostasis.
Results suggest that AIMP1 acts as a regulator of the ER retention of gp96 (show HSP90B1 Antibodies) and provide a new perspective of the regulatory mechanism underlying immune stimulation by gp96 (show HSP90B1 Antibodies).
AIMP1 induces the maturation and activation of dendritic cells, which skew the immune response toward a T helper type 1 (Th1 (show HAND1 Antibodies)) cell response.
AIMP1 negatively regulates TGF-beta (show TGFB1 Antibodies) signaling via stabilization of Smurf2 (show SMURF2 Antibodies).
Mice lacking MSC (show MSC Antibodies) p43 exhibited axon degeneration in motor neurons, defective neuromuscular junctions, muscular atrophy, and motor dysfunction. Furthermore, MSC (show MSC Antibodies) p43 depletion in mice caused disorganization of the axonal neurofilament network.
AIMP1 uses different regions for its diverse extracellular activities.
The protein encoded by this gene is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene has been identified on chromosome 20.
aminoacyl tRNA synthase complex-interacting multifunctional protein 1
, aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
, small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating)
, ARS-interacting multifunctional protein 1
, endothelial monocyte-activating polypeptide 2
, endothelial-monocyte activating polypeptide II
, multisynthase complex auxiliary component p43
, multisynthetase complex auxiliary component p43
, endothelial monocyte activating polypeptide 2
, small inducible cytokine subfamily E, member 1
, ARS inducible multifunctional protein 1
, echinoderm microtubule-associated protein-like 2