You are viewing an incomplete version of our website. Please click to reload the website as full version.

Aminoacylase 1 Proteins (ACY1)

ACY1 encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. Additionally we are shipping Aminoacylase 1 Antibodies (83) and Aminoacylase 1 Kits (11) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ACY1 95 Q03154
ACY1 109652 Q99JW2
Rat ACY1 ACY1 300981 Q6AYS7
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top Aminoacylase 1 Proteins at antibodies-online.com

Showing 10 out of 15 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Human His tag 50 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Mouse His tag 50 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$3,125.83
Details
Yeast Pongo abelii His tag   1 mg Log in to see 56 to 66 Days
$3,129.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$467.86
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   2 μg Log in to see 6 to 11 Days
$142.86
Details

ACY1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Mouse (Murine) ,

Top referenced Aminoacylase 1 Proteins

  1. Human Aminoacylase 1 Protein expressed in Baculovirus infected Insect Cells - ABIN2003031 : Lindner, Täfler-Naumann, Röhm: N-acetylamino acid utilization by kidney aminoacylase-1. in Biochimie 2008 (PubMed)
    Show all 5 references for ABIN2003031

  2. Mouse (Murine) Aminoacylase 1 Protein expressed in Human Cells - ABIN2007138 : Kane, Aguayo, Portanova, Ross, Holley, Kelley, Miller: Isolation of the bombesin/gastrin-releasing peptide receptor from human small cell lung carcinoma NCI-H345 cells. in The Journal of biological chemistry 1991 (PubMed)
    Show all 4 references for ABIN2007138

  3. Human Aminoacylase 1 Protein expressed in Escherichia coli (E. coli) - ABIN667808 : Sass, Mohr, Olbrich, Engelke, Horvath, Fliegauf, Loges, Schweitzer-Krantz, Moebus, Weiler, Kispert, Superti-Furga, Wevers, Omran: Mutations in ACY1, the gene encoding aminoacylase 1, cause a novel inborn error of metabolism. in American journal of human genetics 2006 (PubMed)
    Show all 2 references for ABIN667808

More Proteins for Aminoacylase 1 (ACY1) Interaction Partners

Human Aminoacylase 1 (ACY1) interaction partners

  1. Biochemical analysis showed absence of ACY1 enzyme activity in the patient's fibroblasts.

  2. ACY1 acts as a tumor suppressor in hepatocellular carcinoma.

  3. Report serum aminoacylase-1 as a novel biomarker with potential prognostic utility for long-term outcome in renal transplant recipients with delayed graft function.

  4. Case Report: ACY1-deficient patient presenting with autistic features.

  5. We concluded that ACY1 expression in colorectal cancer varies with stage and appears to play a role in cell proliferation and apoptosis

  6. These data suggest that aminoacylase expression is dysregulated in neuroblastoma (show ARHGEF16 Proteins).

  7. aminoacylase 1 proteins with the mutations p.Arg378Trp, p.Arg378Gln and p.Arg393His were also detected in Western blot analysis

  8. by complementing different active site mutants of human aminoacylase-1, study shows that catalysis occurs at the dimer interface

  9. Genetic deficiency of ACY1 leads to functional ACY1 deficiency and excretion of N-acetylated amino acids.

  10. Because hK1 amidase activity is significantly lower in urine of systolic HF patients, it can be supposed that activity of renal kallikrein-kinin system may be suppressed in this systolic heart failure.

Pig (Porcine) Aminoacylase 1 (ACY1) interaction partners

  1. Apo (show C9orf3 Proteins)-aminoacylase followed similar rules as Holo-enzyme, which suggested the zinc ion may play more important roles on activity other than structure

  2. Based on site-directed mutagenesis, homology modeling and substrate docking studies, a revised catalytic mechanism for porcine metalloenzyme aminoacylase 1 has been proposed.

  3. T347S variant of human Acy1 exhibited markedly increased catalytic efficiency against N-benzoylamino acids

Aminoacylase 1 (ACY1) Protein Profile

Protein Summary

This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18.

Gene names and symbols associated with Aminoacylase 1 Proteins (ACY1)

  • aminoacylase 1 (ACY1)
  • aminoacylase 1 (acy1)
  • aminoacylase 1, gene 1 (acy1.1)
  • aminoacylase 1 (Acy1)
  • 1110014J22Rik protein
  • Acy-1 protein
  • ACY1 protein
  • Acy1a protein
  • Acy1b protein
  • ACY1D protein
  • acylase protein
  • si:zfos-226g1.1 protein
  • zgc:55605 protein
  • zgc:76955 protein

Protein level used designations for Aminoacylase 1 Proteins (ACY1)

aminoacylase-1 , aminoacylase 1 , N-acyl-L-amino-acid amidohydrolase , acylase , ACY IA , ACY IB , ACY-1A , ACY-1B , aminoacylase-1A , aminoacylase-1B , ACY-1 , N-acylamino acid aminohydrolase (Aminoacylase 1)

GENE ID SPECIES
100060631 Equus caballus
393970 Danio rerio
446741 Xenopus laevis
460414 Pan troglodytes
496883 Xenopus (Silurana) tropicalis
100344479 Oryctolagus cuniculus
95 Homo sapiens
109652 Mus musculus
300981 Rattus norvegicus
396930 Sus scrofa
768058 Bos taurus
476602 Canis lupus familiaris
100171519 Pongo abelii
Selected quality suppliers for Aminoacylase 1 Proteins (ACY1)
Did you look for something else?