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The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Additionally we are shipping ACMSD Kits (9) and ACMSD Proteins (9) and many more products for this protein.
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Human Polyclonal ACMSD Primary Antibody for ELISA, WB - ABIN566800
Guillemin, Cullen, Lim, Smythe, Garner, Kapoor, Takikawa, Brew: Characterization of the kynurenine pathway in human neurons. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2007
Acmsd gene expression was found to be under the control of both hepatocyte nuclear factor 4alpha (HNF4alpha (show HNF4A Antibodies)) and peroxisome proliferator-activated receptor alpha (PPARalpha (show PPARA Antibodies)).
ACMSD is mutated in a family with cortical myoclonus, epilepsy, and parkinsonism. ACMSD mutation contributes to the development of Familial cortical myoclonic tremor and epilepsy.
Data report a crystal structure of human ACMSD in complex with the glycolytic intermediate 1,3-dihydroxyacetonephosphate (DHAP (show ALDH3A2 Antibodies)),suggesting a regulatory link between NAD synthesis and glycolysis.
The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase\; EC 184.108.40.206) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.
aminocarboxymuconate semialdehyde decarboxylase
, 2-amino-3-carboxylmuconate-6-semialdehyde decarboxylase
, 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
, 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase-like
, picolinate carboxylase