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Aminolevulinate, delta-, Synthase 1 Proteins (ALAS2)

ALAS2 encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. Additionally we are shipping ALAS2 Antibodies (43) and ALAS2 Kits (16) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ALAS2 100420897  
ALAS2 65155 P13195
ALAS2 11655 Q8VC19
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Top ALAS2 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,685.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 9 to 11 Days
$229.85
Details

ALAS2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Rat (Rattus)

Mouse (Murine)

More Proteins for Aminolevulinate, delta-, Synthase 1 (ALAS2) Interaction Partners

Human Aminolevulinate, delta-, Synthase 1 (ALAS2) interaction partners

  1. ALAS1 mRNA and activity were elevated approximately ~3- and 5-fold, and HMB synthase activity was approximately half-normal (~42%)

  2. These results indicate that ALAS1 is a novel NR5A-target gene and participates in steroid hormone production.

  3. Lon (show LONP1 Proteins) peptidase 1 (show CNDP2 Proteins) (LONP1 (show LONP1 Proteins))-dependent breakdown of mitochondrial 5-aminolevulinic acid synthase protein by heme in human liver cells.

  4. REVIEW: mechanisms involving ALAS deficiency, point mutations, post translational processing, and complex formation with succinyl CoA (show OXCT1 Proteins) synthetase subunit B in the pathogenesis of hereditary sideroblastic anemia.

  5. ALAS expression is regulated by AP-1 (show FOSB Proteins) complex through sequestration of cAMP-response element protein (CRE)-binding protein (CBP (show CREBBP Proteins)) coactivator in human cells

  6. ALAS gene expression is regulated by Hepatic nuclear factor 3 and nuclear factor 1

  7. First described frameshift ALAS2 mutation, CD506-507 (-C).

  8. in the liver of Acute liver failure patients, there may be an increase in free heme concentration which down-regulating ALAS1 gene expression

  9. Alternative splicing of human ALAS1 generates two mRNAs with different 5'-UTRs: a major one, where exon 1B is omitted, and a minor form containing exon 1B.

  10. 5-aminolevulinate synthase gene repression by the potent tumor promoter, TPA (show PLAT Proteins), involves multiple signal transduction pathways

Mouse (Murine) Aminolevulinate, delta-, Synthase 1 (ALAS2) interaction partners

  1. RNAi-mediated silencing of hepatic Alas1 effectively prevents and treats the induced acute attacks in acute intermittent porphyria mice.

  2. Both ALAS1 mRNA and protein content were induced in diabetic animals, accompanied by decreased Akt phosphorylation and increased nuclear FOXO1, PGC-1alpha and FOXO1-PGC-1alpha complex levels.

  3. Egr-1 (show EGR1 Proteins) regulates the transcriptional repression of mouse delta-aminolevulinic acid synthase 1 by heme

  4. Mice bearing a homozygous knock-in allele were lethal by embryonic day 8.5, demonstrating that ALAS-N is essential for early embryogenesis.

  5. Ser (show SIGLEC1 Proteins)-254 is critical for formation of a competent catalytic complex by coupling succinyl-CoA (show OXCT1 Proteins) binding to enzyme conformational equilibria

  6. identified a drug-responsive enhancer in the ALAS1 gene

  7. Histidine-282 impacts a variety of ALAS functions, including substrate and pyridoxal 5'-phosphate (PLP (show C3 Proteins))-binding and catalysis.

  8. The findings show that a B2 SINE retrotransposon can contribute to the regulation of ALAS1 and SINEs in 5'-UTR regions contribute to inter-individual differences in gene expression.

ALAS2 Protein Profile

Protein Summary

This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme\; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Gene names and symbols associated with ALAS2

  • aminolevulinate, delta-, synthase 1 (ALAS1)
  • aminolevulinate, delta-, synthase 1 (alas1)
  • alanyl-tRNA synthetase domain-containing protein (alaS1)
  • alanyl-tRNA synthetase protein (alaS1)
  • aminolevulinate, delta-, synthase 1 pseudogene (ALAS1)
  • aminolevulinate, delta-, synthase 1 pseudogene (LOC100420897)
  • aminolevulinate, delta-, synthase 1 (Alas1)
  • aminolevulinate, delta-, synthetase 1 (alas1)
  • aminolevulinic acid synthase 1 (Alas1)
  • ALAS protein
  • Alas-1 protein
  • Alas-h protein
  • ALAS-N protein
  • ALAS1 protein
  • ALAS3 protein
  • ALASH protein
  • ALASN protein
  • MIG4 protein
  • wu:fb58d01 protein
  • wu:fi12g09 protein

Protein level used designations for ALAS2

aminolevulinate, delta, synthase 1 , 5-aminolevulinate synthase, nonspecific, mitochondrial , aminolevulinate, delta-, synthase 1 , 5-aminolevulinic acid synthase 1 , Delta-ALA synthetase , delta-ALA synthase 1 , delta-aminolevulinate synthase 1 , 5-aminolevulinate synthase 1 , 5-aminolevulinate synthase, nonspecific, mitochondrial-like , alanyl-tRNA synthetase domain-containing protein , alanyl-tRNA synthetase protein , 5-aminolevulinic acid synthase , ALAS-H , migration-inducing protein 4 , delta-ALA synthetase 1 , ALA-S , ALAS-N , aminolevulinic acid synthase 1 , delta-ALA synthetase , ALA-synthase , aminolevulinate synthase 1 , aminolevulinate synthase H , succinyl-CoA: glycine C-succinyl transferase

GENE ID SPECIES
460416 Pan troglodytes
493434 Xenopus (Silurana) tropicalis
698093 Macaca mulatta
100031030 Monodelphis domestica
100060491 Equus caballus
100172808 Pongo abelii
100231674 Taeniopygia guttata
100345847 Oryctolagus cuniculus
100388038 Callithrix jacchus
100473179 Ailuropoda melanoleuca
100607410 Nomascus leucogenys
5821016 Bordetella petrii DSM 12804
6399949 Rhizobium etli CIAT 652
100307125 Sus scrofa
100420897 Homo sapiens
444480 Xenopus laevis
211 Homo sapiens
476600 Canis lupus familiaris
534286 Bos taurus
65155 Rattus norvegicus
552895 Gallus gallus
101112853 Ovis aries
64608 Danio rerio
11655 Mus musculus
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