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Aminolevulinate, delta-, Synthase 2 Proteins (ALAS2)

The product of ALAS2 specifies an erythroid-specific mitochondrially located enzyme. Additionally we are shipping ALAS2 Antibodies (60) and ALAS2 Kits (12) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ALAS2 212 P22557
Rat ALAS2 ALAS2 25748 Q63147
ALAS2 11656 P08680
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Top ALAS2 Proteins at

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days

ALAS2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

More Proteins for Aminolevulinate, delta-, Synthase 2 (ALAS2) Interaction Partners

Human Aminolevulinate, delta-, Synthase 2 (ALAS2) interaction partners

  1. data indicate that the X-linked protoporphyria (show FECH Proteins) variants possess enhanced ALAS activity and ALA dissociation rates, as well as distinct structural properties from those of wild-type hALAS

  2. In this article we add a novel mutation to the previously described 61 different ALAS2 mutations identified in X-linked sideroblastic anaemia patients.

  3. the primary deficiency in ferrochelatase (show FECH Proteins) leads to a secondary increase in ALAS2 expression.

  4. The ALAS2 Y365C mutation impairs pyridoxal 5'-phosphate binding to ALAS2, destabilizing the enzyme. X inactivation was not highly skewed in WBC from affected women. This X-linked dominant mutation perturbs erythropoiesis via cell-nonautonomous effects.

  5. the 130-base pair enhancer region located in the first intron of the ALAS2 gene should be examined in patients with congenital sideroblastic anemia in whom the gene responsible is unknown.

  6. 5 families with X-linked sideroblastic anemia had mutations in a GATA (show QRSL1 Proteins) transcription factor binding site located in a transcriptional enhancer element in intron 1 of the ALAS2 gene.

  7. Loss-of-function FECH (show FECH Proteins) and gain-of-function erythroid-specific ALAS2 mutations causing erythropoietic protoporphyria (show FECH Proteins) and x-linked protoporphyria (show FECH Proteins) in North American patients reveal novel mutations and a high prevalence of X-linked protoporphyria (show FECH Proteins).

  8. ALAS2 gain-of-function mutations increas the specific activity (DeltaAT, DeltaAGTG and p.Q548X) or stability (DeltaG) of the enzyme, thereby leading to the increased erythroid protoporphyrin accumulation causing X-linked protoporphyria (show FECH Proteins).

  9. A large gain-of-function domain within the C-terminus of ALAS2 is associated with X-linked dominant protoporphyria (show FECH Proteins).

  10. Late-onset photosensitivity was caused by ALAS2 mutation in a family with dominant protoporphyria (show FECH Proteins).

Xenopus laevis Aminolevulinate, delta-, Synthase 2 (ALAS2) interaction partners

  1. Xalas2 might be able to synthesize hemoglobin (show HBB Proteins) during hematopoiesis and mediate erythrocyte differentiation by regulating hba3 expression in Xenopus laevis

Mouse (Murine) Aminolevulinate, delta-, Synthase 2 (ALAS2) interaction partners

  1. We propose that the N-terminal truncation offers a cell-specific ALAS2 regulatory mechanism without hindering heme synthesis

  2. Light treatments revealed that ALAS2 expression results in an increase in cell death in comparison to aminolevulinic acid (ALA) treatment producing a similar amount of protoprophyrin IX.

  3. The rate of ALA release is also controlled by a hysteretic kinetic mechanism (observed as a lag (show STMN1 Proteins) in the ALA external aldimine formation progress curve), consistent with conformational changes governing the dissociation of ALA from ALAS.

  4. impaired mitochondrial [Fe-S] cluster biogenesis in Mfrn1(gt/gt (show FABP6 Proteins)) cells results in elevated IRP1 (show ACO1 Proteins) RNA-binding that attenuates ALAS2 mRNA translation and protoporphyrin accumulation

  5. Aberrant iron accumulation and peroxidized state of (ALAS2)-deficient definitive erythroblasts

  6. Gene expression and enzymatic assays indicate that erythroid 5-aminolevulinic acid synthase (Alas2) is decreased in hem6 animals, suggesting a mechanism that could account for the anemia.

ALAS2 Protein Profile

Protein Summary

The product of this gene specifies an erythroid-specific mitochondrially located enzyme. The encoded protein catalyzes the first step in the heme biosynthetic pathway. Defects in this gene cause X-linked pyridoxine-responsive sideroblastic anemia. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with ALAS2

  • aminolevulinate, delta-, synthase 2 (alas2)
  • aminolevulinate, delta-, synthase 2 (ALAS2)
  • aminolevulinate, delta-, synthase 2 (Alas2)
  • aminolevulinate, delta-, synthetase 2 (alas2)
  • aminolevulinic acid synthase 2, erythroid (Alas2)
  • ALAS protein
  • Alas-2 protein
  • alas-e protein
  • ALASE protein
  • ANH1 protein
  • ASB protein
  • cb1063 protein
  • sau protein
  • sauternes protein
  • XLDPP protein
  • XLEPP protein
  • XLSA protein

Protein level used designations for ALAS2

5-aminolevulinate synthase 2 , aminolevulinate, delta-, synthase 2 (sideroblastic/hypochromic anemia) , 5-aminolevulinate synthase, erythroid-specific, mitochondrial , aminolevulinate, delta-, synthase 2 , ALAS-E , delta-ALA synthase 2 , 5-aminolevulinic acid synthase 2 , delta-aminolevulinate synthase 2 , 5-aminolevulinate synthase, erythroid-specific, mitochondrial-like , delta-ALA synthetase , delta-ALA synthetase 2 , Aminolevulinate synthase 2, delta , aminolevulinic acid synthase 2, erythroid , erythroid-specific delta-aminolevulinate synthase ALAS-E , erythroid aminolevulinate synthase , erythroid-specific ALAS

448773 Xenopus (Silurana) tropicalis
473626 Pan troglodytes
704727 Macaca mulatta
100060580 Equus caballus
100174709 Pongo abelii
100410919 Callithrix jacchus
100606858 Nomascus leucogenys
212 Homo sapiens
511791 Bos taurus
25748 Rattus norvegicus
447323 Xenopus laevis
491498 Canis lupus familiaris
64607 Danio rerio
11656 Mus musculus
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