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Aup1 encodes a protein that contains a domain with homology to the ancient conserved region of the archain 1 gene and a domain that may be involved in binding ubiquitin-conjugating enzymes. Additionally we are shipping Ancient Ubiquitous Protein 1 Antibodies (40) and Ancient Ubiquitous Protein 1 Kits (3) and many more products for this protein.
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Monoubiquitinated AUP1 on the lipid droplet surface specifically induces clustering.
A novel role for Aup1 in maintenance of intracellular cholesterol homeostasis via mediation of the endoplasmic reticulum associated degradation of HMG-CoA reductase (show HMGCR Proteins).
AUP1 targeting signals
Dual role of ancient ubiquitous protein 1 (AUP1) in lipid droplet accumulation and endoplasmic reticulum (ER) protein quality control.
The presence of the AUP1-Ube2g2 (show UBE2G2 Proteins) complex at LDs provides a direct molecular link between LDs and the cellular ubiquitination machinery.
binding of Aup1 plays a crucial role in the alpha(IIb)beta(3) inside-out signaling
This gene encodes a protein that contains a domain with homology to the ancient conserved region of the archain 1 gene and a domain that may be involved in binding ubiquitin-conjugating enzymes. The protein encoded by this gene has been shown to bind to the conserved membrane-proximal sequence of the cytoplasmic tail of integrin alpha(IIb) subunits. These subunits play a crucial role in the integrin alpha(IIb)beta(3) inside-out signalling in platelets and megakaryocytes that leads to platelet aggregation and thrombus formation. This gene overlaps the gene for mitochondrial serine protease 25.
ancient ubiquitous protein 1