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anti-Angiomotin (AMOT) Antibodies

AMOT belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. Additionally we are shipping Angiomotin Kits (16) and Angiomotin Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
AMOT 154796 Q4VCS5
AMOT 27494 Q8VHG2
AMOT 300289  
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Top anti-Angiomotin Antibodies at antibodies-online.com

Showing 10 out of 98 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-AMOT Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: 293T cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated DB Dot blot analysis of AMOT Antibody (Phospho Y599) Phospho-specific Pab (ABIN1881054) on nitrocellulose membrane. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6 µg per mL. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human placenta tissue labeled with Anti-Angiomotin Polyclonal Antibody, Unconjugated (ABIN754873) at 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded human colon tissue labeled with Anti-Angiomotin Polyclonal Antibody, Unconjugated (ABIN754873) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Rabbit Un-conjugated WB AMOT Antibody (N-term)  western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the AMOT antibody detected the AMOT protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated WB Western Blot analysis of AMOT expression in transfected 293T cell line by AMOT MaxPab polyclonal antibody.Lane 1: AMOT transfected lysate(74.25 KDa).Lane 2: Non-transfected lysate. 50 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated DB 400 μL Log in to see 6 Days
$457.14
Details
Human Rabbit Un-conjugated WB 400 μL Log in to see 6 Days
$457.14
Details
Human Rabbit Alkaline Phosphatase (AP) DB, ELISA   200 μL Log in to see 8 to 10 Days
$969.83
Details

AMOT Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , , , ,
,
,
, , , , ,
Mouse (Murine)


Rat (Rattus)


Top referenced anti-Angiomotin Antibodies

  1. Human Polyclonal Angiomotin Primary Antibody for DB - ABIN1881054 : Heller, Adu-Gyamfi, Smith-Kinnaman, Babbey, Vora, Xue, Bittman, Stahelin, Wells: Amot recognizes a juxtanuclear endocytic recycling compartment via a novel lipid binding domain. in The Journal of biological chemistry 2010 (PubMed)
    Show all 5 references for ABIN1881054

  2. Human Polyclonal Angiomotin Primary Antibody for WB - ABIN531071 : Chan, Lim, Chong, Pobbati, Huang, Hong: Hippo pathway-independent restriction of TAZ and YAP by angiomotin. in The Journal of biological chemistry 2011 (PubMed)
    Show all 2 references for ABIN531071

  3. Chicken Polyclonal Angiomotin Primary Antibody for WB - ABIN2775938 : Holmgren, Ambrosino, Birot, Tullus, Veitonmäki, Levchenko, Carlson, Musiani, Iezzi, Curcio, Forni, Cavallo, Kiessling: A DNA vaccine targeting angiomotin inhibits angiogenesis and suppresses tumor growth. in Proceedings of the National Academy of Sciences of the United States of America 2006 (PubMed)

More Antibodies against Angiomotin Interaction Partners

Cow (Bovine) Angiomotin (AMOT) interaction partners

  1. Amot and AmotL1 (show AMOTL1 Antibodies) have similar effects on endothelial migration and tight junction formation in vitro. In vivo Amot appears to control the cell polarity and AmotL1 (show AMOTL1 Antibodies) affects the stability of cell-cell junctions.

Zebrafish Angiomotin (AMOT) interaction partners

  1. Thus AMOT is a direct substrate of Lats1 (show LATS1 Antibodies)/2 mediating functions of the Hippo pathway in endothelial cell migration and angiogenesis.

  2. knockdown of Amot reduced the number of filopodia of endoth (show PDPN Antibodies)elial tip cells and severely impaired the migration of intersegmental vessels

  3. Amot and AmotL1 (show AMOTL2 Antibodies) have similar effects on endothelial migration and tight junction formation in vitro. In vivo Amot appears to control the cell polarity and AmotL1 (show AMOTL2 Antibodies) affects the stability of cell-cell junctions.

Human Angiomotin (AMOT) interaction partners

  1. angiomotin and Merlin respectively interface cortical actin filaments and core kinases in Hippo signaling

  2. Study shows miR (show MLXIP Antibodies)-205 significantly downregulated and directly target the 3'-UTR (show UTS2R Antibodies) of AMOT in breast cancer. In vitro, miR (show MLXIP Antibodies)-205 regulates the proliferation and invasion of breast cancer cells through suppression of AMOT expression.

  3. Amot was highly expressed in breast cancer tissues and was important in the promotion of breast cancer cell proliferation and invasion. Amot knockdown in MCF-7 cells decreased the expression of YAP (show YAP1 Antibodies), YAP (show YAP1 Antibodies)/TAZ (show TAZ Antibodies) and LATS1 (show LATS1 Antibodies).

  4. experiments indicate that AMOT and other motin family members function together with NEDD4L (show NEDD4L Antibodies) to help complete immature virion assembly prior to ESCRT-mediated virus budding

  5. AMOT is a crucial suppressor of lung cancer metastasis and highlight its critical role as a tumor suppressor and its potential as a prognostic biomarker and therapeutic target for lung cancer.

  6. angiomotin proteins connect F-actin architecture to YAP (show YAP1 Antibodies) regulation.

  7. Scaffold proteins angiomotin (Amot) and angiomotin-related AmotL1 (show AMOTL1 Antibodies) and AmotL2 (show AMOTL2 Antibodies) were recently identified as negative regulators of YAP (show YAP1 Antibodies) and TAZ (show TAZ Antibodies) by preventing their nuclear translocation.

  8. Within the nucleus, Amot-p130 (show RBL2 Antibodies) was associated with the transcriptional complex containing Yap (show YAP1 Antibodies) and Teads (TEA domain family members) and contributed to the regulation of a subset of Yap (show YAP1 Antibodies) target genes, many of which are associated with tumorigenesis.

  9. These results collectively suggest that the Hippo pathway negatively regulates the actin-binding activity of Amot family members through direct phosphorylation.

  10. Thus AMOT is a direct substrate of Lats1 (show LATS1 Antibodies)/2 mediating functions of the Hippo pathway in endothelial cell migration and angiogenesis.

Mouse (Murine) Angiomotin (AMOT) interaction partners

  1. AMOT is a crucial suppressor of lung cancer metastasis and highlight its critical role as a tumor suppressor and its potential as a prognostic biomarker and therapeutic target for lung cancer.

  2. Within the nucleus, Amot-p130 was associated with the transcriptional complex containing Yap (show YAP1 Antibodies) and Teads (TEA domain family members) and contributed to the regulation of a subset of Yap (show YAP1 Antibodies) target genes, many of which are associated with tumorigenesis.

  3. The loss of Angiomotin, together with Angiomotin-like 2 (show AMOTL2 Antibodies), leads to differentiation of inner cell mass cells and compromised peri (show POSTN Antibodies)-implantation development.

  4. The phosphorylation of S176 in the N-terminal domain of Amot is a critical step for activation of the Hippo pathway in adherens junctions and cell polarity disconnects the Hippo pathway from cell-cell adhesion by sequestering Amot from AJs.

  5. Amot, Amotl1 (show AMOTL1 Antibodies), and Amotl2 (show AMOTL2 Antibodies) are differentially expressed in uterine cells during the peri (show POSTN Antibodies)-implantation period.

  6. A vaccine targeting angiomotin induces an antibody response which alters tumor vessel permeability and hampers the growth of established tumors.

  7. Depletion of Angiomotin in Nf2 (show NF2 Antibodies)(-/-) Schwann cells attenuates the Ras-MAPK (show MAPK1 Antibodies) signaling pathway, impedes cellular proliferation in vitro and tumorigenesis in vivo

  8. Angiomotin may promote neoplastic angiogenesis by both stimulating invasion as well as stabilizing established tubes.

  9. angiomotin, in addition to controlling cell motility, may play a role in the assembly of endothelial cell-cell junctions

  10. p80 (show COIL Antibodies)- and p130-angiomotin play coordinating roles in vascular tube formation by affecting cell migration and cell shape, respectively.

Angiomotin (AMOT) Antigen Profile

Protein Summary

This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with anti-Angiomotin (AMOT) Antibodies

  • angiomotin (AMOT) antibody
  • angiomotin like 2 (AMOTL2) antibody
  • angiomotin (amot) antibody
  • angiomotin (Amot) antibody
  • AMOTL2 antibody
  • C81439 antibody
  • CAG-2 antibody
  • D0Kist1 antibody
  • E230009N18Rik antibody
  • mKIAA1071 antibody
  • RGD1564027 antibody
  • si:dkey-13f9.6 antibody
  • Sii6 antibody
  • wu:fj21a07 antibody

Protein level used designations for anti-Angiomotin (AMOT) Antibodies

angiomotin like 2 , angiomotin-like protein 2 , angiomotin-like protein 2-like , angiomotin p130 isoform , angiomotin p80 isoform

GENE ID SPECIES
100054069 Equus caballus
424863 Gallus gallus
485669 Canis lupus familiaris
538514 Bos taurus
563421 Danio rerio
100402195 Callithrix jacchus
422336 Gallus gallus
154796 Homo sapiens
481022 Canis lupus familiaris
27494 Mus musculus
300289 Rattus norvegicus
100158213 Sus scrofa
535509 Bos taurus
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