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AMOTL2 belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. Additionally we are shipping Angiomotin Like 2 Antibodies (24) and Angiomotin Like 2 Proteins (4) and many more products for this protein.
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Amotl2a function in the control of lateral line primordium cell proliferation is mediated together by the Hippo pathway effector Yap1 (show YAP1 ELISA Kits) and the Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) effector Lef1 (show LEF1 ELISA Kits).
amotL2 associates to the VE-cadherin adhesion complex where it couples adherens junctions to contractile actin fibres.
We demonstrate that amotl2 knockdown in zebrafish wild-type embryos results in embryonic dorsalization, and this effect can be antagonized by co-knockdown of the dorsal inducer beta-catenin2.
Amotl2 plays a pivotal role in polarity, migration and proliferation of angiogenic endothelial cells
Amotl2 interacts preferentially with and facilitates translocation of the phosphorylated c-Src (show SRC ELISA Kits), which may in turn regulate the membrane architecture. These data provide the first evidence that amotl2 is essential for cell movements in vertebrate embryos.
mTORC2 (show CRTC2 ELISA Kits)-mediated phosphorylation of AMOTL2 blocks its ability to inhibit YAP (show YAP1 ELISA Kits) signaling.
AmotL2 expression correlates with loss of tissue architecture in tumors from human breast and colon cancer patients.
Scaffold proteins angiomotin (Amot (show AMOT ELISA Kits)) and angiomotin (show AMOT ELISA Kits)-related AmotL1 (show AMOTL1 ELISA Kits) and AmotL2 were recently identified as negative regulators of YAP (show YAP1 ELISA Kits) and TAZ (show TAZ ELISA Kits) by preventing their nuclear translocation.
These results collectively suggest that the Hippo pathway negatively regulates the actin-binding activity of Amot (show AMOT ELISA Kits) family members through direct phosphorylation.
These results demonstrate a role for Amotl2 in synaptic maturation and support the involvement of podosomes in this process.
AMOTL2 interacts with TAZ (show TAZ ELISA Kits) and modulates transcriptional activity of TAZ (show TAZ ELISA Kits).
AMOTL2 is as a novel activator of LATS2.
AmotL2 disrupts apical-basal cell polarity and promotes tumor invasion.
Amot (show AMOT ELISA Kits), Amotl1 (show AMOTL1 ELISA Kits), and Amotl2 are differentially expressed in uterine cells during the peri (show POSTN ELISA Kits)-implantation period.
Data show that MUPP1 (show MPDZ ELISA Kits) interacts with angiomotin (Amot (show AMOT ELISA Kits)), JEAP (show AMOTL1 ELISA Kits)/Amot (show AMOT ELISA Kits)-like 1 and MASCOT/Amot (show AMOT ELISA Kits)-like 2, and that all the Amot (show AMOT ELISA Kits)/JEAP (show AMOTL1 ELISA Kits) family proteins also interacted with Patj (show INADL ELISA Kits), a close relative of MUPP1 (show MPDZ ELISA Kits).
Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motins protein family.
angiomotin like 1
, angiomotin-like protein 1
, angiomotin like 2
, angiomotin-like 2a
, angiomotin-like protein 1-like
, angiomotin-like protein 2-like
, Leman coiled-coil protein
, angiomotin-like protein 2